mTOR regulates peripheral nerve response to tensile strain

• Published in: Journal of neurophysiology Vol. 117; no. 5; pp. 2075 - 2084
• Main Authors: Love, James M., Bober, Brian G., Orozco, Elisabeth, White, Amanda T., Bremner, Shannon N., Lovering, Richard M., Schenk, Simon, Shah, Sameer B.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.05.2017
• Series: Glial Cells and Neuronal Signaling
• Subjects: Actins - metabolism; Animals; Cells, Cultured; Mechanistic Target of Rapamycin Complex 1 - metabolism; Mechanotransduction, Cellular; Myelin Basic Protein - metabolism; Peripheral Nerves - cytology; Peripheral Nerves - metabolism; Peripheral Nerves - physiology; Rats; Rats, Sprague-Dawley; Schwann Cells - metabolism; Schwann Cells - physiology; Tensile Strength; Tubulin - metabolism; myelin; strain; cytoskeleton; neurofilament; peripheral nerve; mTOR; rapamycin

While excessive tensile strain can be detrimental to nerve function, strain can be a positive regulator of neuronal outgrowth. We used an in vivo rat model of sciatic nerve strain to investigate signaling mechanisms underlying peripheral nerve response to deformation. Nerves were deformed by 11% and...