Inhibitory effect of amiloride and gadolinium on fine afferent nerves in the rat knee : evidence of mechanogated ion channels in joints

• Published in: Experimental brain research Vol. 167; no. 1; pp. 114 - 118
• Main Authors: HEPPELMANN, Bernd, MCDOUGALL, Jason J
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.11.2005; Springer Nature B.V
• Subjects: Afferent Pathways - drug effects; Amiloride - pharmacology; Animals; Biological and medical sciences; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Gadolinium - pharmacology; Lower Extremity - innervation; Lower Extremity - physiology; Male; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Neural Inhibition - drug effects; Physical Stimulation - methods; Rats; Rats, Wistar; Reaction Time - drug effects; Sodium Channel Blockers - pharmacology; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Time Factors; Vertebrates: nervous system and sense organs; Mechanotransduction, Stretch activated channels; Receptive field; Rat; Force; Rodentia; Discharge pattern; Central nervous system; Electrophysiology; Nervous system; Gadolinium; Ionic channel; Joint nerves; Joint; Rotation; Osteoarticular system; Vertebrata; Mammalia; Amiloride; Sodium; Modulation; Body movement; Subtype

Synovial joints are complex sensory organs which provide continuous feedback regarding position sense and degree of limb movement. The transduction mechanisms which convert mechanical forces acting on the joint into an electrochemical signal which can then be transmitted to the central nervous syste...