Gene Polymorphisms of TLR2 and TLR3 in HBV Clearance and HBV-Related Hepatocellular Carcinoma in a Chinese Male Population

• Published in: The International journal of biological markers Vol. 32; no. 2; pp. 195 - 201
• Main Authors: Chen, Dongni, Xie, Weimin, Lu, Yongkui, Su, Shining, Nong, Li, Jia, Yuxian, Liu, Yan, Zhou, Wenxian, Wang, Hongxue, Tan, Aihua
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2017; Sage Publications Ltd
• Subjects: Adult; Biomarkers; Carcinoma, Hepatocellular - complications; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - virology; China; Genetic Association Studies; Genetic diversity; Genetic Predisposition to Disease; Genotype; Haplotypes; Hepatitis B; Hepatitis B virus - pathogenicity; Hepatitis B, Chronic - complications; Hepatitis B, Chronic - genetics; Hepatitis B, Chronic - pathology; Hepatitis B, Chronic - virology; Hepatocellular carcinoma; Humans; Liver cancer; Liver Neoplasms - complications; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Liver Neoplasms - virology; Male; Polymorphism, Single Nucleotide; Single-nucleotide polymorphism; TLR2 protein; TLR3 protein; Toll-Like Receptor 2 - genetics; Toll-Like Receptor 3 - genetics; Toll-like receptors; Toll-like receptors; Hepatocellular carcinoma; Polymorphism

Background The Toll-like receptor plays an essential role in controlling immunity and inflammation. This study was to investigate the relationships of genetic variants in TLR2 and TLR3 with hepatitis B virus (HBV) natural clearance and HBV-related hepatocellular carcinoma (HCC) risk in a Chinese mal...