BCG Vaccination Enhances the Immunogenicity of Subsequent Influenza Vaccination in Healthy Volunteers: A Randomized, Placebo-Controlled Pilot Study

• Published in: The Journal of infectious diseases Vol. 212; no. 12; pp. 1930 - 1938
• Main Authors: Leentjens, Jenneke, Kox, Matthijs, Stokman, Robin, Gerretsen, Jelle, Diavatopoulos, Dimitri A., van Crevel, Reinout, Rimmelzwaan, Guus F., Pickkers, Peter, Netea, Mihai G.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 15.12.2015
• Subjects: Adult; Antibodies, Viral - blood; BCG Vaccine - administration & dosage; Healthy Volunteers; Hemagglutination Inhibition Tests; Humans; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Injections, Intramuscular; Male; Pilot Projects; Placebos - administration & dosage; Vaccination - methods; VIRUSES; Young Adult; trained immunity; influenza vaccination; heterologous immunity; BCG; innate immune memory; vaccination strategy

Background. Influenza-related morbidity and mortality remain high. Seasonal vaccination is the backbone of influenza management but does not always result in protective antibody titers. Nonspecific effects of BCG vaccination related to enhanced function of myeloid antigen-presenting cells have been...