PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis

• Published in: Nature communications Vol. 4; no. 1; p. 1618
• Main Authors: Ko, Frankie Chi Fat, Chan, Lo-Kong, Man-Fong Sze, Karen, Yeung, Yin-Shan, Yuk-Ting Tse, Edith, Lu, Ping, Yu, Ming-Hua, Oi-Lin Ng, Irene, Yam, Judy Wai Ping
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 2013; Nature Publishing Group
• Subjects: 631/67; 631/80/86; Animals; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinases - metabolism; Dimerization; GTPase-Activating Proteins - chemistry; GTPase-Activating Proteins - physiology; HEK293 Cells; Humanities and Social Sciences; Humans; Mice; multidisciplinary; Neoplasm Metastasis; Phosphorylation; Science; Science (multidisciplinary); Transplantation, Heterologous; Tumor Suppressor Proteins - chemistry; Tumor Suppressor Proteins - physiology

Deleted in Liver Cancer 1 (DLC1) is a tumour suppressor that encodes a RhoGTPase-activating protein (RhoGAP) and is frequently inactivated in many human cancers. The RhoGAP activity of DLC1 against Rho signalling is well documented and is strongly associated with the tumour suppressor functions of D...