Hyperpolarization-activated cyclic-nucleotide-gated channels potentially modulate axonal excitability at different thresholds

• Published in: Journal of neurophysiology Vol. 118; no. 6; pp. 3044 - 3050
• Main Authors: Weerasinghe, Dinushi, Menon, Parvathi, Vucic, Steve
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.12.2017
• Series: Nervous System Pathophysiology
• Subjects: hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels; threshold; sensory axon

Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels mediate differences in sensory and motor axonal excitability at different thresholds in animal models. Importantly, HCN channels are responsible for voltage-gated inward rectifying ( I h ) currents activated during hyperpolarization....