Peripuberty Is a Sensitive Period for Prefrontal Parvalbumin Interneuron Activity to Impact Adult Cognitive Flexibility

• Published in: Developmental neuroscience Vol. 47; no. 2; pp. 127 - 138
• Main Authors: Sahyoun, Gabriella M., Do, Trang Dao, Anqueira-Gonzàlez, Amanda, Hornblass, Ava, Canetta, Sarah E.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.04.2025
• Subjects: Animals; Cognition - physiology; Cognitive Flexibility; Interneurons - metabolism; Interneurons - physiology; Male; Mice; Neuronal Plasticity - physiology; Parvalbumins - metabolism; Prefrontal Cortex - cytology; Prefrontal Cortex - growth & development; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiology; Research Article; Visual Cortex; Peripuberty; Adolescence; Prefrontal cortex; Parvalbumin; Sensitive period

Abstract Introduction: Developmental windows in which experiences can elicit long-lasting effects on brain circuitry and behavior are called “sensitive periods” and reflect a state of heightened plasticity. The classic example of a sensitive period comes from studies of sensory systems, like the vis...