Tumor microenvironment characterization in esophageal cancer identifies prognostic relevant immune cell subtypes and gene signatures

• Published in: Aging (Albany, NY.) Vol. 13; no. 24; pp. 26118 - 26136
• Main Authors: Zhang, Yuhong, Zhu, Minqi, Mo, Junxian, Xian, Lei
• Format: Journal Article
• Language: English
• Published: United States Impact Journals 26.12.2021
• Subjects: Algorithms; Esophageal Neoplasms - genetics; Esophageal Neoplasms - immunology; Humans; Models, Statistical; Prognosis; Research Paper; Tumor Microenvironment - genetics; esophageal cancer; immune cell subtypes; tumor microenvironment; prognostic model; bioinformatics

Esophageal cancer (ESCA) is a common malignancy in the digestive system with a high mortality rate and poor prognosis. Tumor microenvironment (TME) plays an important role in the tumorigenesis, progression and therapy resistance of ESCA, whereas its role in predicting clinical outcomes has not been...