LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease - Bonello, Fiona; Hassoun, Sidi-Mohamed; Mouton-Liger, François; Shin, Yea Seul; Muscat, Adeline; Tesson, Christelle; Lesage, Suzanne; Beart, Philip M; Brice, Alexis; Krupp, Johannes; Corvol, Jean-Christophe; Corti, Olga (Human molecular genetics, 2019)
Keywords: Adult; Aged; Benzodiazepinones - pharmacology; Carbonyl Cyanide m-Chlorophenyl Hydrazone - analogs & derivatives; Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology; Female; Fibroblasts - drug effects; Fibroblasts - pathology; Fluorescence Resonance Energy Transfer; Genetics; Human genetics; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - antagonists & inhibitors; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics; Life Sciences; Male; Middle Aged; Mitochondria - genetics; Mitochondria - pathology; Mitophagy - drug effects; Mutation; Neurobiology; Neurons and Cognition; Parkinson Disease - genetics; Parkinson Disease - pathology; Phosphorylation; Primary Cell Culture; Protein Kinases - genetics; Pyrimidines - pharmacology; Ubiquitin-Protein Ligases - genetics