Catecholamines and their enzymes in discrete brain areas of rats after space flight on biosatellites Cosmos

• Published in: Acta astronautica Vol. 10; no. 5; pp. 295 - 300
• Main Authors: Kvetǹanskỳ, R., Čulman, J., Serova, L.V., Tigranjan, R.A., Torda, T., Macho, L.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.05.1983; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Catecholamines - metabolism; Dopamine - metabolism; Dopamine beta-Hydroxylase - metabolism; Fundamental and applied biological sciences. Psychology; Hypothalamus - enzymology; Hypothalamus - metabolism; Immobilization; Male; Monoamine Oxidase - metabolism; Rats; Space Flight; Space life sciences; Stress, Physiological - metabolism; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects; Tyrosine 3-Monooxygenase - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weightlessness; Epinephrine; Dopamine; Rat; Enzyme; Rodentia; Central nervous system; Brain (Vertebrata); Weightlessness; Space flight; Catecholamine; Vertebrata; Mammalia; Biogenic amine; Neurotransmitter; Environment; Norepinephrine
• ISSN: 0094-5765; 1879-2030
• DOI: 10.1016/0094-5765(83)90080-2

The activity of the catecholaminergic system was measured in the hypothalamus of rats which had experienced an 18.5–19.5-day-long stay in the state of weightlessness during space flights on board Soviet biosatellites of the type Cosmos. In the first two experiments, Cosmos 782 and 936, the concentration of norepinephrine and the activities of synthesizing enzymes tyrosine hydroxylase and dopamine-β-hydroxylase and of the degrading enzyme monoamine oxidase were measured in the total hypothalamus. None of the given parameters was changed after space flight. In the light of the changes of these parameters recorded after exposure to acute stress on Earth, this finding indicates that long-term state of weightlessness does not represent an intensive stressogenic stimulus for the system studied. In the space experiment Cosmos 1129, the concentration of norepinephrine, epinephrine, and dopamine was studied in isolated nuclei of the hypothalamus of rats within 6–10 hr following return from space. Norepinephrine was found to be significantly reduced in the arcuate nucleus, median eminence and periventricular nucleus, epinephrine in the median eminence, periventricular and suprachiasmatic nuclei, whereas dopamine was not significantly changed after space flight. The decreased catecholamine levels found in some hypothalamic nuclei of rats which had undergone space flight indicate that no chronic intensive stressor could have acted during the flight, otherwise the catecholamine concentration would have been increased in the nuclei. The decreased levels must have been induced by the effect of a stressogenic factor acting for a short time only, and that either during the landing maneuver or immediately after landing. Thus long-term exposure of the organism to the state of weightlessness does not represent a stressogenic stimulus for the catecholaminergic system in the hypothalamus, which is one of the regulators of the activation of neuroendocrine reactions under stress.