Prenatal alcohol exposure (PAE) reduces the size of the forepaw representation in forepaw barrel subfield (FBS) cortex in neonatal rats : relationship between periphery and central representation

• Published in: Experimental brain research Vol. 172; no. 3; pp. 387 - 396
• Main Authors: MARGRET, Cecilia P, CHAPPELL, Tyson D, LI, Cheng X, JAN, Taha A, MATTA, Shannon G, ELBERGER, Andrea J, WATERS, Robert S
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.07.2006; Springer Nature B.V
• Subjects: Alcohol-Induced Disorders, Nervous System - physiopathology; Animals; Biological and medical sciences; Central Nervous System Depressants - adverse effects; Disease Models, Animal; Ethanol; Ethanol - adverse effects; Female; Fetal Alcohol Spectrum Disorders - physiopathology; Fetal alcohol syndrome; Forelimb - growth & development; Forelimb - innervation; Forelimb - physiopathology; Fundamental and applied biological sciences. Psychology; Limb Deformities, Congenital - chemically induced; Limb Deformities, Congenital - physiopathology; Male; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Neurosciences; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - physiopathology; Rats; Rats, Sprague-Dawley; Rodents; Skin; Somatosensory Cortex - drug effects; Somatosensory Cortex - physiopathology; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Touch - physiology; Vertebrates: nervous system and sense organs; Fetal alcohol syndrome; Sensorimotor deficits; Ethanol; Rat; Rodentia; Central nervous system; Limb defects; Encephalon; Barrels; Somatosensory cortex; Barrel cortex; Vertebrata; Sensorimotor coordination; Somatotopy; Mammalia; Somesthetic pathway; Upper limb; Fetal alcohol spectrum disorder n

Prenatal alcohol exposure (PAE) alters limb development that may lead to structural and functional abnormalities of the limb reported in children diagnosed with Fetal Alcohol Spectrum Disorder. To determine whether PAE alters the central representation of the forelimb we used the rodent barrel corte...