Cytoprotective activities of kinetin purine isosteres
[Display omitted] Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here we report the synthesis of kinetin isosteres with the purine ring replaced by other bicyclic heterocycles, and...
Saved in:
| Published in | Bioorganic & medicinal chemistry Vol. 33; p. 115993 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
OXFORD
Elsevier Ltd
01.03.2021
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | [Display omitted]
Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here we report the synthesis of kinetin isosteres with the purine ring replaced by other bicyclic heterocycles, and the biological evaluation of their activity in several in vitro models related to neurodegenerative diseases. Our findings indicate that kinetin isosteres protect Friedreich́s ataxia patient-derived fibroblasts against glutathione depletion, protect neuron-like SH-SY5Y cells from glutamate-induced oxidative damage, and correct aberrant splicing of the ELP1 gene in fibroblasts derived from a familial dysautonomia patient. Although the mechanism of action of kinetin derivatives remains unclear, our data suggest that the cytoprotective activity of some purine isosteres is mediated by their ability to reduce oxidative stress. Further, the studies of permeation across artificial membrane and model gut and blood-brain barriers indicate that the compounds are orally available and can reach central nervous system. Overall, our data demonstrate that isosteric replacement of the kinetin purine scaffold is a fruitful strategy for improving known biological activities of kinetin and discovering novel therapeutic opportunities. |
|---|---|
| AbstractList | Kinetin (N-6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here we report the synthesis of kinetin isosteres with the purine ring replaced by other bicyclic heterocycles, and the biological evaluation of their activity in several in vitro models related to neurodegenerative diseases. Our findings indicate that kinetin isosteres protect Friedreich's ataxia patient-derived fibroblasts against glutathione depletion, protect neuron-like SH-SY5Y cells from glutamate-induced oxidative damage, and correct aberrant splicing of the ELP1 gene in fibroblasts derived from a familial dysautonomia patient. Although the mechanism of action of kinetin derivatives remains unclear , our data suggest that the cytoprotective activity of some purine isosteres is mediated by their ability to reduce oxidative stress. Further, the studies of permeation across artificial membrane and model gut and blood-brain barriers indicate that the compounds are orally available and can reach central nervous system. Overall, our data demonstrate that isosteric replacement of the kinetin purine scaffold is a fruitful strategy for improving known biological activities of kinetin and discovering novel therapeutic opportunities. Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here we report the synthesis of kinetin isosteres with the purine ring replaced by other bicyclic heterocycles, and the biological evaluation of their activity in several in vitro models related to neurodegenerative diseases. Our findings indicate that kinetin isosteres protect Friedreich́s ataxia patient-derived fibroblasts against glutathione depletion, protect neuron-like SH-SY5Y cells from glutamate-induced oxidative damage, and correct aberrant splicing of the ELP1 gene in fibroblasts derived from a familial dysautonomia patient. Although the mechanism of action of kinetin derivatives remains unclear, our data suggest that the cytoprotective activity of some purine isosteres is mediated by their ability to reduce oxidative stress. Further, the studies of permeation across artificial membrane and model gut and blood-brain barriers indicate that the compounds are orally available and can reach central nervous system. Overall, our data demonstrate that isosteric replacement of the kinetin purine scaffold is a fruitful strategy for improving known biological activities of kinetin and discovering novel therapeutic opportunities. [Display omitted] Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here we report the synthesis of kinetin isosteres with the purine ring replaced by other bicyclic heterocycles, and the biological evaluation of their activity in several in vitro models related to neurodegenerative diseases. Our findings indicate that kinetin isosteres protect Friedreich́s ataxia patient-derived fibroblasts against glutathione depletion, protect neuron-like SH-SY5Y cells from glutamate-induced oxidative damage, and correct aberrant splicing of the ELP1 gene in fibroblasts derived from a familial dysautonomia patient. Although the mechanism of action of kinetin derivatives remains unclear, our data suggest that the cytoprotective activity of some purine isosteres is mediated by their ability to reduce oxidative stress. Further, the studies of permeation across artificial membrane and model gut and blood-brain barriers indicate that the compounds are orally available and can reach central nervous system. Overall, our data demonstrate that isosteric replacement of the kinetin purine scaffold is a fruitful strategy for improving known biological activities of kinetin and discovering novel therapeutic opportunities. Kinetin (N -furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal models. Here we report the synthesis of kinetin isosteres with the purine ring replaced by other bicyclic heterocycles, and the biological evaluation of their activity in several in vitro models related to neurodegenerative diseases. Our findings indicate that kinetin isosteres protect Friedreich́s ataxia patient-derived fibroblasts against glutathione depletion, protect neuron-like SH-SY5Y cells from glutamate-induced oxidative damage, and correct aberrant splicing of the ELP1 gene in fibroblasts derived from a familial dysautonomia patient. Although the mechanism of action of kinetin derivatives remains unclear, our data suggest that the cytoprotective activity of some purine isosteres is mediated by their ability to reduce oxidative stress. Further, the studies of permeation across artificial membrane and model gut and blood-brain barriers indicate that the compounds are orally available and can reach central nervous system. Overall, our data demonstrate that isosteric replacement of the kinetin purine scaffold is a fruitful strategy for improving known biological activities of kinetin and discovering novel therapeutic opportunities. |
| ArticleNumber | 115993 |
| Author | Gándara Barreiro, Zoila Soural, Miroslav Maková, Barbara Hajdúch, Marián Strnad, Miroslav Voller, Jiří Zatloukal, Marek Medvedíková, Martina D'Autréaux, Benoit Monfort, Beata Gonzalez, Gabriel Vítek, Dominik Kadlecová, Alena Lišková, Barbora Khirsariya, Prashant Havlíček, Libor Paruch, Kamil Ručilová, Veronika Mik, Václav |
| Author_xml | – sequence: 1 givenname: Barbara surname: Maková fullname: Maková, Barbara organization: Department of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc CZ-78371, Czech Republic – sequence: 2 givenname: Václav orcidid: 0000-0002-8515-3035 surname: Mik fullname: Mik, Václav organization: Department of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc CZ-78371, Czech Republic – sequence: 3 givenname: Barbora surname: Lišková fullname: Lišková, Barbora organization: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc CZ-77515, Czech Republic – sequence: 4 givenname: Gabriel surname: Gonzalez fullname: Gonzalez, Gabriel organization: Department of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc CZ-78371, Czech Republic – sequence: 5 givenname: Dominik surname: Vítek fullname: Vítek, Dominik organization: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc CZ-77515, Czech Republic – sequence: 6 givenname: Martina surname: Medvedíková fullname: Medvedíková, Martina organization: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc CZ-77515, Czech Republic – sequence: 7 givenname: Beata orcidid: 0000-0001-6698-0644 surname: Monfort fullname: Monfort, Beata organization: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France – sequence: 8 givenname: Veronika surname: Ručilová fullname: Ručilová, Veronika organization: Department of Organic Chemistry, Faculty of Science, Palacký University, 17. listopadu 1192/12, Olomouc CZ-783-71, Czech Republic – sequence: 9 givenname: Alena surname: Kadlecová fullname: Kadlecová, Alena organization: Department of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc CZ-78371, Czech Republic – sequence: 10 givenname: Prashant orcidid: 0000-0001-8570-1866 surname: Khirsariya fullname: Khirsariya, Prashant organization: Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Brno, Czech Republic – sequence: 11 givenname: Zoila surname: Gándara Barreiro fullname: Gándara Barreiro, Zoila organization: Department of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc CZ-78371, Czech Republic – sequence: 12 givenname: Libor surname: Havlíček fullname: Havlíček, Libor organization: Isotope Laboratory, The Czech Academy of Science, Institute of Experimental Botany, Vídeňská 1083, Praha 4 CZ-14220, Czech Republic – sequence: 13 givenname: Marek surname: Zatloukal fullname: Zatloukal, Marek organization: Department of Chemical Biolology and Genetics, Centre of the Region Hana for Biotechnological and Agricultural Research, Palacký University, Šlechtitelů 27, Olomouc CZ-78371, Czech Republic – sequence: 14 givenname: Miroslav surname: Soural fullname: Soural, Miroslav organization: Department of Organic Chemistry, Faculty of Science, Palacký University, 17. listopadu 1192/12, Olomouc CZ-783-71, Czech Republic – sequence: 15 givenname: Kamil surname: Paruch fullname: Paruch, Kamil organization: Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Brno, Czech Republic – sequence: 16 givenname: Benoit orcidid: 0000-0002-1276-3019 surname: D'Autréaux fullname: D'Autréaux, Benoit organization: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France – sequence: 17 givenname: Marián surname: Hajdúch fullname: Hajdúch, Marián organization: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc CZ-77515, Czech Republic – sequence: 18 givenname: Miroslav surname: Strnad fullname: Strnad, Miroslav organization: Department of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc CZ-78371, Czech Republic – sequence: 19 givenname: Jiří orcidid: 0000-0001-7378-8941 surname: Voller fullname: Voller, Jiří email: jiri.voller@upol.cz organization: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc CZ-77515, Czech Republic |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33497938$$D View this record in MEDLINE/PubMed https://hal.science/hal-03141631$$DView record in HAL |
| BookMark | eNqNkUGL1DAYhoOsuLOrP8CL9KgsHfMlaabB01J0VxjwoueQJl8x40wzJuks--9N6ThHMZcvhOd94XtyQ67GMCIhb4GugYL8uFv3B7tmlMEaoFGKvyArEFLUnCu4IiuqZFvTVslrcpPSjlLKhIJX5JpzoTaKtyvSdM85HGPIaLM_YWXm4bPHVIWh-uVHzH6sjlMst8qnkDJGTK_Jy8HsE745z1vy48vn791jvf328LW739aWt5tcQ9-7RiiO1DjW9IwPvWK8dZvGUKSukcYqAEeVGgCV69WgKLNcbGzDqegtvyUflt6fZq-P0R9MfNbBeP14v9XzG-UgQHI4QWHfL2zZ5veEKeuDTxb3ezNimJJmogUpuGpmFBbUxpBSxOHSDVTPZvVOF7N6NqsXsyXz7lw_9Qd0l8RflQVoF-AJ-zAk63G0eMGKe8m45A2dD-t8NtmHsQvTmEv07v-jhf600FjMnzxGfU44H8svahf8P_b4A8oYqg0 |
| CitedBy_id | crossref_primary_10_2174_1389557522666220812125205 crossref_primary_10_1016_j_taap_2023_116655 crossref_primary_10_1016_j_jsbmb_2022_106194 crossref_primary_10_3390_ph15060764 crossref_primary_10_1002_ardp_202300378 crossref_primary_10_3390_molecules26175412 |
| Cites_doi | 10.1016/j.apsb.2012.10.004 10.1186/2050-6511-13-12 10.1371/journal.pone.0211602 10.4103/0378-6323.157446 10.1016/j.bmc.2010.09.030 10.1111/jnc.12220 10.1002/cne.10662 10.1038/ejhg.2009.212 10.1371/journal.pone.0116502 10.1016/j.bmc.2019.115230 10.1177/2472555218792264 10.1016/S1367-5931(03)00055-3 10.1073/pnas.1801772115 10.1080/10543401003618983 10.1186/1756-0500-1-95 10.1016/j.phytochem.2018.02.008 10.3389/fncel.2015.00091 10.1371/journal.pone.0080755 10.1038/cddiscovery.2017.13 10.1186/s40673-017-0062-x 10.1038/s41467-019-11470-9 10.1016/j.ejmech.2018.03.043 10.1016/j.tiv.2014.09.014 10.1002/cpnc.61 10.1002/ijc.24168 10.1016/j.bmc.2007.03.038 10.1016/j.cell.2013.07.030 10.1073/pnas.1415525112 10.1093/hmg/ddh046 10.1016/j.arr.2019.100958 10.1186/s13024-017-0149-0 10.1016/j.ejmech.2017.12.053 10.1016/j.bbrc.2003.09.019 10.1007/s10517-007-0390-6 10.1089/jmf.2016.3829 10.1016/j.ejmech.2019.111806 10.1016/j.phytochem.2018.02.015 10.1210/en.2011-0184 10.1016/j.pbi.2009.07.002 10.1080/15257770903155550 10.1021/co500090t 10.1086/318810 10.1023/A:1020642808437 10.2174/1871520611313040016 10.1021/js9803205 10.1016/0031-9422(73)85105-2 10.1021/ja01592a021 10.1007/978-3-319-63001-4_14 10.1021/jo01075a023 10.1126/scitranslmed.3004986 10.2144/03345dd02 10.1203/PDR.0b013e31822e1825 10.1006/bbrc.1994.1752 10.1016/S0169-409X(00)00128-9 10.1039/jr9600000131 |
| ContentType | Journal Article |
| Copyright | 2021 Copyright © 2021. Published by Elsevier Ltd. Distributed under a Creative Commons Attribution 4.0 International License |
| Copyright_xml | – notice: 2021 – notice: Copyright © 2021. Published by Elsevier Ltd. – notice: Distributed under a Creative Commons Attribution 4.0 International License |
| DBID | 1KM BLEPL DTL HGBXW NPM AAYXX CITATION 7X8 1XC |
| DOI | 10.1016/j.bmc.2021.115993 |
| DatabaseName | Index Chemicus Web of Science Core Collection Science Citation Index Expanded Web of Science - Science Citation Index Expanded - 2021 PubMed CrossRef MEDLINE - Academic Hyper Article en Ligne (HAL) |
| DatabaseTitle | Web of Science PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | Web of Science PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 1KM name: Index Chemicus url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC sourceTypes: Enrichment Source Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology Chemistry |
| EISSN | 1464-3391 |
| EndPage | 115993 |
| ExternalDocumentID | oai_HAL_hal_03141631v1 10_1016_j_bmc_2021_115993 33497938 000623635000002 S0968089621000018 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: European Regional Development Fund project ENOCH grantid: CZ.02.1.01/0.0/0.0/16_019/0000868 – fundername: Operational Programme Research, Development and Education -project "Preclinical Progression of New Organic Compounds with Targeted Biological Activity" grantid: CZ.02.1.01/0.0/0.0/16_025/0007381 – fundername: Ministry of Education, Youth and Sports of the Czech Republic; Ministry of Education, Youth & Sports - Czech Republic grantid: LTC18078 – fundername: European Structural and Investment Funds – fundername: COST Action; European Cooperation in Science and Technology (COST) grantid: CA15133 |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATCM AAXUO ABBQC ABFNM ABGSF ABJNI ABLVK ABMAC ABMZM ABUDA ABYKQ ABZDS ACDAQ ACGFS ACIUM ACRLP ADBBV ADECG ADEZE ADUVX AEBSH AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AFZHZ AGUBO AGYEJ AIEXJ AIKHN AITUG AJOXV AJRQY AJSZI ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CS3 DOVZS DU5 EBS EFJIC EFLBG EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA IHE J1W KOM LCYCR LZ2 M29 M2Z M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 ROL RPZ SCC SDF SDG SDP SES SPC SPCBC SSH SSK SSP SSU SSZ T5K UPT XPP YK3 ~02 ~G- 1KM AAXKI AKRWK BLEPL DTL GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED RIG NPM 53G AAQXK AAYXX ABXDB ACNNM ADMUD AFFNX AFJKZ AGHFR AGRDE AHHHB ASPBG AVWKF AZFZN CITATION EJD FEDTE FGOYB G-2 HEA HMK HMO HMS HMT HVGLF HZ~ R2- SAE SCB SEW SOC SPT WUQ ZMT 7X8 1XC |
| ID | FETCH-LOGICAL-c387t-1bbd5493e0ad25b23fb9238d75a0e0d56ac911d099f1e9db9f902c347c5304bc3 |
| IEDL.DBID | AIKHN |
| ISICitedReferencesCount | 6 |
| ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000623635000002 |
| ISSN | 0968-0896 |
| IngestDate | Fri Sep 06 12:42:53 EDT 2024 Fri Aug 16 05:48:12 EDT 2024 Thu Sep 26 16:01:38 EDT 2024 Sat Sep 28 08:30:12 EDT 2024 Wed Sep 18 08:23:55 EDT 2024 Fri Sep 27 16:52:24 EDT 2024 Fri Feb 23 02:48:46 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | DHE Neuroprotection DMSO DFO ATCC TFA BSA DMEM Mitoprotection – familial dysautonomia bioisostery – Friedreich́s ataxia FBS EDIPA ISC HOBt Kinetin DMF GSH BSO DIC PBS ADME ECACC HBBS MW PAMPA Cytokinin DCM RED TEA R-LA PI FA ATRA FXN CELLS bioisostery - Friedreichs ataxia Mitoprotection - familial dysautonomia ANALOGS TISSUE DISCOVERY IN-VITRO MESSENGER-RNA BIOLOGICAL-ACTIVITY RECEPTORS DERIVATIVES EXPRESSION |
| Language | English |
| License | Copyright © 2021. Published by Elsevier Ltd. Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
| MergedId | FETCHMERGED-LOGICAL-c387t-1bbd5493e0ad25b23fb9238d75a0e0d56ac911d099f1e9db9f902c347c5304bc3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-7378-8941 0000-0002-8515-3035 0000-0001-6698-0644 0000-0001-8570-1866 0000-0002-1276-3019 0000-0002-2382-7997 0000-0002-4834-908X 0000-0003-2200-3977 0000-0002-2806-794X 0000-0002-8196-878X |
| PMID | 33497938 |
| PQID | 2481643951 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | elsevier_sciencedirect_doi_10_1016_j_bmc_2021_115993 crossref_primary_10_1016_j_bmc_2021_115993 proquest_miscellaneous_2481643951 pubmed_primary_33497938 webofscience_primary_000623635000002 webofscience_primary_000623635000002CitationCount hal_primary_oai_HAL_hal_03141631v1 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-03-01 |
| PublicationDateYYYYMMDD | 2021-03-01 |
| PublicationDate_xml | – month: 03 year: 2021 text: 2021-03-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | OXFORD |
| PublicationPlace_xml | – name: OXFORD – name: England |
| PublicationTitle | Bioorganic & medicinal chemistry |
| PublicationTitleAbbrev | BIOORGAN MED CHEM |
| PublicationTitleAlternate | Bioorg Med Chem |
| PublicationYear | 2021 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | Colombo, Falvella, De Cecco (b0065) 2009; 124 Lemrová, Smyslová, Popa (b0205) 2014; 16 Kulikov, Rzhaninova, Goldshtein, Boldyrev (b0265) 2007; 144 Slaugenhaupt, Johnson, Paquette, Zhang, Marugan (b0115) 2020 Vanda, Soural, Canale (b0210) 2018; 144 Anderson, Qiu, Rubin (b0175) 2003; 310 Kadlecová, Maková, Artal-Sanz, Strnad, Voller (b0010) 2019; 55 Gervason, Larkem, Mansour (b0155) 2019; 10 Ito, Eguchi, Imagawa, Akai, Mochizuki, Tsujimoto (b0260) 2017; 3 Stone, Shang, Tomarev (b0160) 2003; 460 Nishida, Adati, Ozawa (b0270) 2008; 1 Kubiasová, Mik, Nisler (b0145) 2018; 150 de Roulet, DeVita (b0120) 2019 Borková, Frydrych, Jakubcová (b0180) 2020; 185 Ferriero, Manco, Lamantea (b0230) 2013; 5 Hammer, Harper, Ryan (b0195) 2001; 4 Pastore, Puccio (b0240) 2013; 126 Pros, Fernández-Rodríguez, Benito (b0030) 2010; 18 Wu (b0200) 2010; 20 Rogozińska, Kroon, Salemink (b0135) 1973; 12 Zhang, Luo, Ding, Lu (b0285) 2012; 2 Ottria, Casati, Baldoli, Maier, Ciuffreda (b0075) 2010; 18 Xicoy, Wieringa, Martens (b0250) 2017; 12 Irvine, Takahashi, Lockhart (b0185) 1999; 88 Slaugenhaupt, Blumenfeld, Gill (b0275) 2001; 68 Richardson, Yang, Wen, Simpkins (b0220) 2011; 152 Savelieva, Oslovsky, Karlov (b0140) 2018; 149 Axelrod, Liebes, Gold-von Simson (b0035) 2011; 70 Slaugenhaupt, Mull, Leyne (b0025) 2004; 13 Castiglioni, Ciuffreda, Casati, Ottria, A.M. Maier (b0085) 2013; 13 Davoll (b0125) 1960 Robins, Furcht, Grauer, Jones (b0150) 1956; 78 Bürk (b0215) 2017; 4 Wanitphakdeedecha, Meeprathom, Manuskiatti (b0295) 2015; 81 Kim, Seo, Oh (b0170) 2017; 20 Hertz, Berthet, Sos (b0045) 2013; 154 Kritis, Stamoula, Paniskaki, Vavilis (b0255) 2015; 9 Barciszewski, Siboska, Pedersen, Clark, Rattan (b0020) 1997 Doležal, Popa, Hauserová (b0060) 2007; 15 Richardson, Simpkins (b0225) 2012; 13 Oslovsky, Drenichev, Alexeev, Solyev, Esipov, Mikhailov (b0090) 2018; 75 Rattan, Clark (b0015) 1994; 201 Bonnier, Keating, Wróbel (b0235) 2015; 29 Artursson, Palm, Luthman (b0190) 2001; 46 Di, Kerns (b0280) 2003; 7 Yannai, Zonszain, Donyo, Ast (b0040) 2019; 14 Ottria, Casati, Maier, Mariotti, Ciuffreda (b0070) 2009; 28 Carrasco, Stamm, Patel (b0165) 2003; 34 Yoshida, Kataoka, Miyauchi (b0100) 2015; 112 Salani, Urbina, Brenner (b0105) 2019; 24 Yu, Wang, Sun (b0290) 2015; 10 Ali, Zhang, Dai, Huang (b0245) 2003; 16 Voller, Maková, Kadlecová, Gonzalez, Strnad (b0005) 2017; 6 Matušková, Zatloukal, Voller (b0095) 2020; 28 Bowie, Maiuri, Alpaugh (b0050) 2018; 115 Werner, Schmülling (b0055) 2009; 12 Weiss, Robins, Noell (b0130) 1960 Hönig, Plíhalová, Spíchal (b0110) 2018; 150 Amiable, Pochet, Padilla, Labesse, Kaminski (b0080) 2013; 8 Vanda, D (WOS:000425198100054) 2018; 144 Amiable, C (WOS:000327311900094) 2013; 8 Nishida, Yuichiro (MEDLINE:18957096) 2008; 1 Kritis, AA (WOS:000352415600001) 2015; 9 Barciszewski, J (WOS:A1997XW75900060) 1997; 414 Richardson, TE (WOS:000319690100001) 2012; 13 Borkova, L (WOS:000503099900027) 2020; 185 Axelrod, FB (WOS:000296121100007) 2011; 70 Ali, A (WOS:000178549300006) 2003; 16 Irvine, JD (WOS:000077960100004) 1999; 88 Hammer, Oyvind (ZOOREC:ZOOR13700068172) 2001; 4 Oslovsky, Vladimir E (MEDLINE:30299587) 2018; 75 Xicoy, H (WOS:000396291600001) 2017; 12 Kadlecova, A (WOS:000491638300011) 2019; 55 ROBINS, RK (WOS:A1956WB83400021) 1956; 78 Bowie, LE (WOS:000439574700015) 2018; 115 Werner, T (WOS:000271137200003) 2009; 12 Artursson, P (WOS:000167611100003) 2001; 46 Ottria, R (WOS:000270022800002) 2009; 28 WEISS, R (WOS:A1960WT07900023) 1960; 25 Matuskova, V (WOS:000504647600008) 2020; 28 Slaugenhaupt, SA (WOS:000166994200005) 2001; 68 Castiglioni, S (WOS:000317850500016) 2013; 13 Pastore, A (WOS:000321892100005) 2013; 126 Stone, JS (WOS:000182630500004) 2003; 460 Yannai, S (WOS:000461573000004) 2019; 14 Ferriero, R (WOS:000315922500008) 2013; 5 Voller, J (000623635000002.1) 1000; 6 Yu, H (WOS:000348822600027) 2015; 10 Yoshida, M (WOS:000350224900050) 2015; 112 (000623635000002.23) 2020 Pros, E (WOS:000276955500018) 2010; 18 Hertz, NT (WOS:000323202500007) 2013; 154 ROGOZINSKA, JH (WOS:A1973Q393200002) 1973; 12 (000623635000002.24) 2019 Kubiasova, K (WOS:000435623400001) 2018; 150 Di, L (WOS:000183940000013) 2003; 7 Honig, M (WOS:000430891400069) 2018; 150 Zhang, DL (WOS:000413446000002) 2012; 2 Salani, M (WOS:000454142300005) 2019; 24 Wu, JR (WOS:000281082200004) 2010; 20 Anderson, SL (WOS:000185904300056) 2003; 310 Lemrova, B (WOS:000343026800007) 2014; 16 Richardson, TE (WOS:000291925700023) 2011; 152 Ottria, R (WOS:000284059500032) 2010; 18 Wanitphakdeedecha, R (WOS:000360632900034) 2015; 81 Ito, K (WOS:000463082900026) 2017; 3 DAVOLL, J (WOS:A1960WK69200026) 1960 Slaugenhaupt, SA (WOS:000188795300007) 2004; 13 Colombo, F (WOS:000264647600024) 2009; 124 Bonnier, F (WOS:000347746600016) 2015; 29 Carrasco, RA (WOS:000182859200021) 2003; 34 RATTAN, SIS (WOS:A1994NQ80500025) 1994; 201 Brk, Katrin (MEDLINE:28405347) 2017; 4 Dolezal, K (WOS:000246649000015) 2007; 15 Gervason, S (WOS:000479188700009) 2019; 10 Savelieva, EM (WOS:000430778200016) 2018; 149 Kim, MS (WOS:000393920900006) 2017; 20 Kulikov, AV (WOS:000253198700034) 2007; 144 Yoshida (10.1016/j.bmc.2021.115993_b0100) 2015; 112 Ali (10.1016/j.bmc.2021.115993_b0245) 2003; 16 Bürk (10.1016/j.bmc.2021.115993_b0215) 2017; 4 Gervason (10.1016/j.bmc.2021.115993_b0155) 2019; 10 Pastore (10.1016/j.bmc.2021.115993_b0240) 2013; 126 Di (10.1016/j.bmc.2021.115993_b0280) 2003; 7 Borková (10.1016/j.bmc.2021.115993_b0180) 2020; 185 Bonnier (10.1016/j.bmc.2021.115993_b0235) 2015; 29 Vanda (10.1016/j.bmc.2021.115993_b0210) 2018; 144 Slaugenhaupt (10.1016/j.bmc.2021.115993_b0115) 2020 Lemrová (10.1016/j.bmc.2021.115993_b0205) 2014; 16 Ottria (10.1016/j.bmc.2021.115993_b0070) 2009; 28 Ferriero (10.1016/j.bmc.2021.115993_b0230) 2013; 5 Rattan (10.1016/j.bmc.2021.115993_b0015) 1994; 201 Slaugenhaupt (10.1016/j.bmc.2021.115993_b0275) 2001; 68 Ottria (10.1016/j.bmc.2021.115993_b0075) 2010; 18 Hammer (10.1016/j.bmc.2021.115993_b0195) 2001; 4 Doležal (10.1016/j.bmc.2021.115993_b0060) 2007; 15 Davoll (10.1016/j.bmc.2021.115993_b0125) 1960 Oslovsky (10.1016/j.bmc.2021.115993_b0090) 2018; 75 Robins (10.1016/j.bmc.2021.115993_b0150) 1956; 78 Yu (10.1016/j.bmc.2021.115993_b0290) 2015; 10 Yannai (10.1016/j.bmc.2021.115993_b0040) 2019; 14 Salani (10.1016/j.bmc.2021.115993_b0105) 2019; 24 Amiable (10.1016/j.bmc.2021.115993_b0080) 2013; 8 Wu (10.1016/j.bmc.2021.115993_b0200) 2010; 20 Zhang (10.1016/j.bmc.2021.115993_b0285) 2012; 2 Hertz (10.1016/j.bmc.2021.115993_b0045) 2013; 154 Kim (10.1016/j.bmc.2021.115993_b0170) 2017; 20 Carrasco (10.1016/j.bmc.2021.115993_b0165) 2003; 34 Colombo (10.1016/j.bmc.2021.115993_b0065) 2009; 124 Hönig (10.1016/j.bmc.2021.115993_b0110) 2018; 150 Kadlecová (10.1016/j.bmc.2021.115993_b0010) 2019; 55 Kubiasová (10.1016/j.bmc.2021.115993_b0145) 2018; 150 Axelrod (10.1016/j.bmc.2021.115993_b0035) 2011; 70 Stone (10.1016/j.bmc.2021.115993_b0160) 2003; 460 Richardson (10.1016/j.bmc.2021.115993_b0225) 2012; 13 Barciszewski (10.1016/j.bmc.2021.115993_b0020) 1997 Nishida (10.1016/j.bmc.2021.115993_b0270) 2008; 1 Bowie (10.1016/j.bmc.2021.115993_b0050) 2018; 115 Savelieva (10.1016/j.bmc.2021.115993_b0140) 2018; 149 Richardson (10.1016/j.bmc.2021.115993_b0220) 2011; 152 Kulikov (10.1016/j.bmc.2021.115993_b0265) 2007; 144 de Roulet (10.1016/j.bmc.2021.115993_b0120) 2019 Anderson (10.1016/j.bmc.2021.115993_b0175) 2003; 310 Wanitphakdeedecha (10.1016/j.bmc.2021.115993_b0295) 2015; 81 Werner (10.1016/j.bmc.2021.115993_b0055) 2009; 12 Castiglioni (10.1016/j.bmc.2021.115993_b0085) 2013; 13 Matušková (10.1016/j.bmc.2021.115993_b0095) 2020; 28 Voller (10.1016/j.bmc.2021.115993_b0005) 2017; 6 Pros (10.1016/j.bmc.2021.115993_b0030) 2010; 18 Irvine (10.1016/j.bmc.2021.115993_b0185) 1999; 88 Kritis (10.1016/j.bmc.2021.115993_b0255) 2015; 9 Artursson (10.1016/j.bmc.2021.115993_b0190) 2001; 46 Rogozińska (10.1016/j.bmc.2021.115993_b0135) 1973; 12 Weiss (10.1016/j.bmc.2021.115993_b0130) 1960 Slaugenhaupt (10.1016/j.bmc.2021.115993_b0025) 2004; 13 Xicoy (10.1016/j.bmc.2021.115993_b0250) 2017; 12 Ito (10.1016/j.bmc.2021.115993_b0260) 2017; 3 |
| References_xml | – volume: 18 start-page: 8396 year: 2010 end-page: 8402 ident: b0075 article-title: N6-Alkyladenosines: synthesis and evaluation of in vitro anticancer activity publication-title: Bioorg Med Chem contributor: fullname: Ciuffreda – volume: 16 start-page: 558 year: 2014 end-page: 565 ident: b0205 article-title: Directed solid-phase synthesis of trisubstituted imidazo[4,5- c ]pyridines and imidazo[4,5- b ]pyridines publication-title: ACS Comb. Sci. contributor: fullname: Popa – volume: 13 start-page: 12 year: 2012 ident: b0225 article-title: R- and S-Equol have equivalent cytoprotective effects in Friedreich’s Ataxia publication-title: BMC Pharmacol Toxicol. contributor: fullname: Simpkins – volume: 115 start-page: E7081 year: 2018 end-page: E7090 ident: b0050 article-title: N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation publication-title: PNAS contributor: fullname: Alpaugh – volume: 18 start-page: 614 year: 2010 end-page: 617 ident: b0030 article-title: Modulation of aberrant NF1 pre-mRNA splicing by kinetin treatment publication-title: Eur J Hum Genet contributor: fullname: Benito – volume: 13 start-page: 672 year: 2013 end-page: 678 ident: b0085 article-title: N6-Isopentenyladenosine and its analogue n6-benzyladenosine induce cell cycle arrest and apoptosis in bladder carcinoma T24 cells publication-title: Anticancer Agents Med Chem contributor: fullname: A.M. Maier – volume: 6 year: 2017 ident: b0005 article-title: Plant hormone cytokinins for modulating human aging and age-related diseases publication-title: Hormones in Ageing and Longevity. Healthy Ageing and Longevity contributor: fullname: Strnad – volume: 29 start-page: 124 year: 2015 end-page: 131 ident: b0235 article-title: Cell viability assessment using the Alamar blue assay: a comparison of 2D and 3D cell culture models publication-title: Toxicol In Vitro contributor: fullname: Wróbel – volume: 20 start-page: 140 year: 2017 end-page: 151 ident: b0170 article-title: Neuroprotective effect of halophyte Salicornia herbacea L. is mediated by activation of heme oxygenase-1 in mouse hippocampal HT22 cells publication-title: J Med Food contributor: fullname: Oh – volume: 201 start-page: 665 year: 1994 end-page: 672 ident: b0015 article-title: Kinetin delays the onset of ageing characteristics in human fibroblasts publication-title: Biochem Biophys Res Commun contributor: fullname: Clark – volume: 144 start-page: 626 year: 2007 end-page: 629 ident: b0265 article-title: Expression of NMDA receptors in multipotent stromal cells of human adipose tissue under conditions of retinoic acid-induced differentiation publication-title: Bull Exp Biol Med contributor: fullname: Boldyrev – volume: 150 start-page: 1 year: 2018 end-page: 11 ident: b0145 article-title: Design, synthesis and perception of fluorescently labeled isoprenoid cytokinins publication-title: Phytochemistry contributor: fullname: Nisler – volume: 144 start-page: 716 year: 2018 end-page: 729 ident: b0210 article-title: Novel non-sulfonamide 5-HT 6 receptor partial inverse agonist in a group of imidazo[4,5- b ]pyridines with cognition enhancing properties publication-title: Eur J Med Chem contributor: fullname: Canale – volume: 88 start-page: 28 year: 1999 end-page: 33 ident: b0185 article-title: MDCK (Madin-Darby Canine Kidney) cells: a tool for membrane permeability screening publication-title: J Pharm Sci contributor: fullname: Lockhart – year: 1997 ident: b0020 article-title: A mechanism for the in vivo formation of N6-furfuryladenine, kinetin, as a secondary oxidative damage product of DNA publication-title: FEBS Lett contributor: fullname: Rattan – volume: 150 start-page: 946 year: 2018 end-page: 957 ident: b0110 article-title: New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress publication-title: Eur J Med Chem contributor: fullname: Spíchal – volume: 154 start-page: 737 year: 2013 end-page: 747 ident: b0045 article-title: A neo-substrate that amplifies catalytic activity of parkinson’s-disease- related kinase PINK1 publication-title: Cell contributor: fullname: Sos – volume: 24 start-page: 57 year: 2019 end-page: 67 ident: b0105 article-title: Development of a screening platform to identify small molecules that modify ELP1 Pre-mRNA splicing in familial dysautonomia publication-title: SLAS Disc: Adv Sci Drug Disc contributor: fullname: Brenner – volume: 185 start-page: 111806 year: 2020 ident: b0180 article-title: Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid publication-title: Eur J Med Chem contributor: fullname: Jakubcová – volume: 460 start-page: 487 year: 2003 end-page: 502 ident: b0160 article-title: Expression of Prox1 defines regions of the avian otocyst that give rise to sensory or neural cells publication-title: J Comp Neurol contributor: fullname: Tomarev – volume: 5 year: 2013 ident: b0230 article-title: Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis publication-title: Sci Transl Med contributor: fullname: Lamantea – volume: 1 start-page: 95 year: 2008 ident: b0270 article-title: Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y publication-title: BMC Res Notes contributor: fullname: Ozawa – volume: 4 start-page: 1 year: 2001 end-page: 9 ident: b0195 article-title: PAST: paleontological statistics software package for education and data analysis publication-title: Palaeontol Electron contributor: fullname: Ryan – volume: 112 start-page: 2764 year: 2015 end-page: 2769 ident: b0100 article-title: Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia publication-title: PNAS contributor: fullname: Miyauchi – volume: 12 start-page: 2087 year: 1973 end-page: 2092 ident: b0135 article-title: Influence of alterations in the purine ring on biological activity of cytokinins publication-title: Phytochemistry contributor: fullname: Salemink – volume: 46 start-page: 27 year: 2001 end-page: 43 ident: b0190 article-title: Caco-2 monolayers in experimental and theoretical predictions of drug transport publication-title: Adv Drug Deliv Rev contributor: fullname: Luthman – volume: 75 year: 2018 ident: b0090 article-title: Synthesis of Cytokinins via Enzymatic Arsenolysis of purine nucleosides publication-title: Curr Protoc Nucleic Acid Chem contributor: fullname: Mikhailov – volume: 9 start-page: 91 year: 2015 ident: b0255 article-title: Researching glutamate – induced cytotoxicity in different cell lines: a comparative/collective analysis/study publication-title: Front Cell Neurosci contributor: fullname: Vavilis – volume: 2 start-page: 549 year: 2012 end-page: 561 ident: b0285 article-title: Preclinical experimental models of drug metabolism and disposition in drug discovery and development publication-title: Acta Pharmaceutica Sinica B contributor: fullname: Lu – year: 2020 ident: b0115 article-title: United States Patent: 10676475 – Compounds for improving mRNA splicing contributor: fullname: Marugan – volume: 3 start-page: 1 year: 2017 end-page: 10 ident: b0260 article-title: MPP+ induces necrostatin-1-and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells publication-title: Cell Death Discov contributor: fullname: Tsujimoto – volume: 124 start-page: 2179 year: 2009 end-page: 2185 ident: b0065 article-title: Pharmacogenomics and analogues of the antitumour agent N 6 -isopentenyladenosine publication-title: Int J Cancer contributor: fullname: De Cecco – volume: 70 start-page: 480 year: 2011 end-page: 483 ident: b0035 article-title: Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia publication-title: Pediatr Res contributor: fullname: Gold-von Simson – start-page: 131 year: 1960 end-page: 138 ident: b0125 article-title: 26. Pyrrolo[2,3-d]pyrimidines publication-title: J Chem Soc contributor: fullname: Davoll – volume: 78 start-page: 2418 year: 1956 end-page: 2422 ident: b0150 article-title: Potential purine antagonists. II. Synthesis of some 7- and 5,7-substituted pyrazolo [4,3-d]pyrimidines publication-title: J Am Chem Soc contributor: fullname: Jones – volume: 126 start-page: 43 year: 2013 end-page: 52 ident: b0240 article-title: Frataxin: a protein in search for a function publication-title: J Neurochem contributor: fullname: Puccio – year: 2019 ident: b0120 article-title: United States Patent: 10167286 – Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease contributor: fullname: DeVita – volume: 149 start-page: 161 year: 2018 end-page: 177 ident: b0140 article-title: Cytokinin activity of N6-benzyladenine derivatives assayed by interaction with the receptors in planta, in vitro, and in silico publication-title: Phytochemistry contributor: fullname: Karlov – volume: 68 start-page: 598 year: 2001 end-page: 605 ident: b0275 article-title: Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia publication-title: Am J Hum Genet contributor: fullname: Gill – volume: 12 start-page: 527 year: 2009 end-page: 538 ident: b0055 article-title: Cytokinin action in plant development publication-title: Curr Opin Plant Biol contributor: fullname: Schmülling – start-page: 765 year: 1960 end-page: 770 ident: b0130 article-title: Potential purine antagonists. XXIII. Synthesis of some 7-substituted amino-v-triazolo(d)pyrimidines1 publication-title: J Org Chem contributor: fullname: Noell – volume: 152 start-page: 2742 year: 2011 end-page: 2749 ident: b0220 article-title: Estrogen protection in Friedreich’s Ataxia skin fibroblasts publication-title: Endocrinology contributor: fullname: Simpkins – volume: 13 start-page: 429 year: 2004 end-page: 436 ident: b0025 article-title: Rescue of a human mRNA splicing defect by the plant cytokinin kinetin publication-title: Hum Mol Genet contributor: fullname: Leyne – volume: 4 start-page: 1 year: 2017 end-page: 9 ident: b0215 article-title: Friedreich Ataxia: current status and future prospects publication-title: Cerebellum Ataxias contributor: fullname: Bürk – volume: 20 start-page: 954 year: 2010 end-page: 964 ident: b0200 article-title: Statistical inference for tumor growth inhibition T/C ratio publication-title: J Biopharm Stat contributor: fullname: Wu – volume: 14 year: 2019 ident: b0040 article-title: Combinatorial treatment increases IKAP levels in human cells generated from Familial Dysautonomia patients publication-title: PLoS One contributor: fullname: Ast – volume: 12 start-page: 1 year: 2017 end-page: 11 ident: b0250 article-title: The SH-SY5Y cell line in Parkinson’s disease research: a systematic review publication-title: Mol Neurodegener contributor: fullname: Martens – volume: 34 start-page: 1064 year: 2003 end-page: 1067 ident: b0165 article-title: One-step cellular caspase-3/7 assay publication-title: Biotechniques contributor: fullname: Patel – volume: 81 start-page: 547 year: 2015 ident: b0295 article-title: Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin publication-title: Indian J Dermatol Venereol Leprol contributor: fullname: Manuskiatti – volume: 15 start-page: 3737 year: 2007 end-page: 3747 ident: b0060 article-title: Preparation, biological activity and endogenous occurrence of N6-benzyladenosines publication-title: Bioorg Med Chem contributor: fullname: Hauserová – volume: 16 start-page: 285 year: 2003 end-page: 293 ident: b0245 article-title: Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids publication-title: Biometals contributor: fullname: Huang – volume: 7 start-page: 402 year: 2003 end-page: 408 ident: b0280 article-title: Profiling drug-like properties in discovery research publication-title: Curr Opin Chem Biol contributor: fullname: Kerns – volume: 10 year: 2019 ident: b0155 article-title: Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin publication-title: Nat Commun contributor: fullname: Mansour – volume: 28 start-page: 115230 year: 2020 ident: b0095 article-title: New aromatic 6-substituted 2′-deoxy-9-(β)-d-ribofuranosylpurine derivatives as potential plant growth regulators publication-title: Bioorg Med Chem contributor: fullname: Voller – volume: 28 start-page: 736 year: 2009 end-page: 751 ident: b0070 article-title: Novel isopentenyladenosine analogues: synthesis, characterization, and evaluation of antiproliferative activity on bladder carcinoma cells publication-title: Nucleosides Nucleotides Nucleic Acids contributor: fullname: Ciuffreda – volume: 310 start-page: 627 year: 2003 end-page: 633 ident: b0175 article-title: EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia publication-title: Biochem Biophys Res Commun contributor: fullname: Rubin – volume: 8 year: 2013 ident: b0080 article-title: N6-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1. Fraidenraich D, ed. publication-title: PLoS One contributor: fullname: Kaminski – volume: 55 start-page: 100958 year: 2019 ident: b0010 article-title: The plant hormone kinetin in disease therapy and healthy aging publication-title: Age Res Rev contributor: fullname: Voller – volume: 10 year: 2015 ident: b0290 article-title: A new PAMPA model proposed on the basis of a synthetic phospholipid membrane. Hofmann A, ed. publication-title: PLoS One contributor: fullname: Sun – volume: 414 start-page: 457 year: 1997 ident: WOS:A1997XW75900060 article-title: A mechanism for the in vivo formation of N-6-furfuryladenine, kinetin, as a secondary oxidative damage product of DNA publication-title: FEBS LETTERS contributor: fullname: Barciszewski, J – volume: 25 start-page: 765 year: 1960 ident: WOS:A1960WT07900023 article-title: POTENTIAL PURINE ANTAGONISTS .23. SYNTHESIS OF SOME 7-SUBSTITUTED AMINO-V-TRIAZOLO(D)PYRIMIDINES publication-title: JOURNAL OF ORGANIC CHEMISTRY contributor: fullname: WEISS, R – volume: 2 start-page: 549 year: 2012 ident: WOS:000413446000002 article-title: Preclinical experimental models of drug metabolism and disposition in drug discovery and development publication-title: ACTA PHARMACEUTICA SINICA B doi: 10.1016/j.apsb.2012.10.004 contributor: fullname: Zhang, DL – volume: 13 start-page: ARTN 12 year: 2012 ident: WOS:000319690100001 article-title: R- and S-Equol have equivalent cytoprotective effects in Friedreich's Ataxia publication-title: BMC PHARMACOLOGY & TOXICOLOGY doi: 10.1186/2050-6511-13-12 contributor: fullname: Richardson, TE – volume: 14 start-page: ARTN e0211602 year: 2019 ident: WOS:000461573000004 article-title: Combinatorial treatment increases IKAP levels in human cells generated from Familial Dysautonomia patients publication-title: PLOS ONE doi: 10.1371/journal.pone.0211602 contributor: fullname: Yannai, S – volume: 81 year: 2015 ident: WOS:000360632900034 article-title: Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin publication-title: INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY doi: 10.4103/0378-6323.157446 contributor: fullname: Wanitphakdeedecha, R – volume: 88 start-page: 28 year: 1999 ident: WOS:000077960100004 article-title: MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening publication-title: JOURNAL OF PHARMACEUTICAL SCIENCES contributor: fullname: Irvine, JD – volume: 18 start-page: 8396 year: 2010 ident: WOS:000284059500032 article-title: N-6-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity publication-title: BIOORGANIC & MEDICINAL CHEMISTRY doi: 10.1016/j.bmc.2010.09.030 contributor: fullname: Ottria, R – volume: 126 start-page: 43 year: 2013 ident: WOS:000321892100005 article-title: Frataxin: a protein in search for a function publication-title: JOURNAL OF NEUROCHEMISTRY doi: 10.1111/jnc.12220 contributor: fullname: Pastore, A – volume: 201 start-page: 665 year: 1994 ident: WOS:A1994NQ80500025 article-title: KINETIN DELAYS THE ONSET OF AGING CHARACTERISTICS IN HUMAN FIBROBLASTS publication-title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS contributor: fullname: RATTAN, SIS – volume: 460 start-page: 487 year: 2003 ident: WOS:000182630500004 article-title: Expression of proxl defines regions of the avian otocyst that give rise to sensory or neural cells publication-title: JOURNAL OF COMPARATIVE NEUROLOGY doi: 10.1002/cne.10662 contributor: fullname: Stone, JS – volume: 13 start-page: 672 year: 2013 ident: WOS:000317850500016 article-title: N6-Isopentenyladenosine and its Analogue N6-Benzyladenosine Induce Cell Cycle Arrest and Apoptosis in Bladder Carcinoma T24 Cells publication-title: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY contributor: fullname: Castiglioni, S – volume: 18 start-page: 614 year: 2010 ident: WOS:000276955500018 article-title: Modulation of aberrant NF1 pre-mRNA splicing by kinetin treatment publication-title: EUROPEAN JOURNAL OF HUMAN GENETICS doi: 10.1038/ejhg.2009.212 contributor: fullname: Pros, E – volume: 10 start-page: ARTN e0116502 year: 2015 ident: WOS:000348822600027 article-title: A New PAMPA Model Proposed on the Basis of a Synthetic Phospholipid Membrane publication-title: PLOS ONE doi: 10.1371/journal.pone.0116502 contributor: fullname: Yu, H – volume: 6 year: 1000 ident: 000623635000002.1 article-title: Plant hormone cytokinins for modulating human aging and age-related diseases publication-title: Hormones in Ageing and Longevity. Healthy Ageing and Longevity contributor: fullname: Voller, J – volume: 28 start-page: ARTN 115230 year: 2020 ident: WOS:000504647600008 article-title: New aromatic 6-substituted 2 '-deoxy-9-(beta)-D-ribofuranosylpurine derivatives as potential plant growth regulators publication-title: BIOORGANIC & MEDICINAL CHEMISTRY doi: 10.1016/j.bmc.2019.115230 contributor: fullname: Matuskova, V – volume: 24 start-page: 57 year: 2019 ident: WOS:000454142300005 article-title: Development of a Screening Platform to Identify Small Molecules That Modify ELP1 Pre-mRNA Splicing in Familial Dysautonomia publication-title: SLAS DISCOVERY doi: 10.1177/2472555218792264 contributor: fullname: Salani, M – volume: 7 start-page: 402 year: 2003 ident: WOS:000183940000013 article-title: Profiling drug-like properties in discovery research publication-title: CURRENT OPINION IN CHEMICAL BIOLOGY doi: 10.1016/S1367-5931(03)00055-3 contributor: fullname: Di, L – volume: 115 start-page: E7081 year: 2018 ident: WOS:000439574700015 article-title: N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA doi: 10.1073/pnas.1801772115 contributor: fullname: Bowie, LE – volume: 20 start-page: 954 year: 2010 ident: WOS:000281082200004 article-title: Statistical Inference for Tumor Growth Inhibition T/C Ratio publication-title: JOURNAL OF BIOPHARMACEUTICAL STATISTICS doi: 10.1080/10543401003618983 contributor: fullname: Wu, JR – volume: 1 start-page: 95 year: 2008 ident: MEDLINE:18957096 article-title: Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y. publication-title: BMC research notes doi: 10.1186/1756-0500-1-95 contributor: fullname: Nishida, Yuichiro – volume: 149 start-page: 161 year: 2018 ident: WOS:000430778200016 article-title: Cytokinin activity of N-6-benzyladenine derivatives assayed by interaction with the receptors in planta, in vitro, and in silico publication-title: PHYTOCHEMISTRY doi: 10.1016/j.phytochem.2018.02.008 contributor: fullname: Savelieva, EM – volume: 9 start-page: ARTN 91 year: 2015 ident: WOS:000352415600001 article-title: Researching glutamate - induced cytotoxicity in different cell lines: a comparative/collective analysis/study publication-title: FRONTIERS IN CELLULAR NEUROSCIENCE doi: 10.3389/fncel.2015.00091 contributor: fullname: Kritis, AA – volume: 4 start-page: Unpaginated year: 2001 ident: ZOOREC:ZOOR13700068172 article-title: PAST: paleontological statistics software package for education and data analysis. publication-title: Palaeontologia Electronica contributor: fullname: Hammer, Oyvind – volume: 8 start-page: ARTN e80755 year: 2013 ident: WOS:000327311900094 article-title: N-6-Substituted AMPs Inhibit Mammalian Deoxynucleotide N-Hydrolase DNPH1 publication-title: PLOS ONE doi: 10.1371/journal.pone.0080755 contributor: fullname: Amiable, C – volume: 70 start-page: 480 year: 2011 ident: WOS:000296121100007 article-title: Kinetin Improves IKBKAP mRNA Splicing in Patients With Familial Dysautonomia publication-title: PEDIATRIC RESEARCH contributor: fullname: Axelrod, FB – volume: 3 start-page: ARTN 17013 year: 2017 ident: WOS:000463082900026 article-title: MPP plus induces necrostatin-1-and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells publication-title: CELL DEATH DISCOVERY doi: 10.1038/cddiscovery.2017.13 contributor: fullname: Ito, K – volume: 4 start-page: 4 year: 2017 ident: MEDLINE:28405347 article-title: Friedreich Ataxia: current status and future prospects. publication-title: Cerebellum & ataxias doi: 10.1186/s40673-017-0062-x contributor: fullname: Brk, Katrin – volume: 10 start-page: ARTN 3566 year: 2019 ident: WOS:000479188700009 article-title: Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin publication-title: NATURE COMMUNICATIONS doi: 10.1038/s41467-019-11470-9 contributor: fullname: Gervason, S – volume: 150 start-page: 946 year: 2018 ident: WOS:000430891400069 article-title: New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2018.03.043 contributor: fullname: Honig, M – volume: 29 start-page: 124 year: 2015 ident: WOS:000347746600016 article-title: Cell viability assessment using the Alamar blue assay: A comparison of 2D and 3D cell culture models publication-title: TOXICOLOGY IN VITRO doi: 10.1016/j.tiv.2014.09.014 contributor: fullname: Bonnier, F – volume: 75 start-page: e61 year: 2018 ident: MEDLINE:30299587 article-title: Synthesis of Cytokinins via Enzymatic Arsenolysis of Purine Nucleosides. publication-title: Current protocols in nucleic acid chemistry doi: 10.1002/cpnc.61 contributor: fullname: Oslovsky, Vladimir E – volume: 124 start-page: 2179 year: 2009 ident: WOS:000264647600024 article-title: Pharmaeogenomics and analogues of the antitumour agent N-6-isopentenyladenosine publication-title: INTERNATIONAL JOURNAL OF CANCER doi: 10.1002/ijc.24168 contributor: fullname: Colombo, F – volume: 34 start-page: 1064 year: 2003 ident: WOS:000182859200021 article-title: One-step cellular caspase-3/7 assay publication-title: BIOTECHNIQUES contributor: fullname: Carrasco, RA – year: 2019 ident: 000623635000002.24 article-title: Compositions and methods using-the same for treatment of neurodegenerative and mitochondrial disease publication-title: United States Patent – volume: 12 start-page: 2087 year: 1973 ident: WOS:A1973Q393200002 article-title: DEAZAPURINE DERIVATIVES .11. INFLUENCE OF ALTERATIONS IN PURINE RING ON BIOLOGICAL-ACTIVITY OF CYTOKININS publication-title: PHYTOCHEMISTRY contributor: fullname: ROGOZINSKA, JH – volume: 15 start-page: 3737 year: 2007 ident: WOS:000246649000015 article-title: Preparation, biological activity and endogenous occurrence of N-6-benzyladenosines publication-title: BIOORGANIC & MEDICINAL CHEMISTRY doi: 10.1016/j.bmc.2007.03.038 contributor: fullname: Dolezal, K – volume: 154 start-page: 737 year: 2013 ident: WOS:000323202500007 article-title: A Neo-Substrate that Amplifies Catalytic Activity of Parkinson's-Disease-Related Kinase PINK1 publication-title: CELL doi: 10.1016/j.cell.2013.07.030 contributor: fullname: Hertz, NT – volume: 112 start-page: 2764 year: 2015 ident: WOS:000350224900050 article-title: Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA doi: 10.1073/pnas.1415525112 contributor: fullname: Yoshida, M – volume: 13 start-page: 429 year: 2004 ident: WOS:000188795300007 article-title: Rescue of a human mRNA splicing defect by the plant cytokinin kinetin publication-title: HUMAN MOLECULAR GENETICS doi: 10.1093/hmg/ddh046 contributor: fullname: Slaugenhaupt, SA – start-page: 131 year: 1960 ident: WOS:A1960WK69200026 article-title: PYRROLO[2,3-D]PYRIMIDINES publication-title: JOURNAL OF THE CHEMICAL SOCIETY contributor: fullname: DAVOLL, J – year: 2020 ident: 000623635000002.23 article-title: Compounds for improving mRNA splicing publication-title: United States Patent – volume: 55 start-page: ARTN 100958 year: 2019 ident: WOS:000491638300011 article-title: The plant hormone kinetin in disease therapy and healthy aging publication-title: AGEING RESEARCH REVIEWS doi: 10.1016/j.arr.2019.100958 contributor: fullname: Kadlecova, A – volume: 12 start-page: ARTN 10 year: 2017 ident: WOS:000396291600001 article-title: The SH-SY5Y cell line in Parkinson's disease research: a systematic review publication-title: MOLECULAR NEURODEGENERATION doi: 10.1186/s13024-017-0149-0 contributor: fullname: Xicoy, H – volume: 144 start-page: 716 year: 2018 ident: WOS:000425198100054 article-title: Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2017.12.053 contributor: fullname: Vanda, D – volume: 310 start-page: 627 year: 2003 ident: WOS:000185904300056 article-title: EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia publication-title: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS doi: 10.1016/j.bbrc.2003.09.019 contributor: fullname: Anderson, SL – volume: 5 start-page: ARTN 175ra31 year: 2013 ident: WOS:000315922500008 article-title: Phenylbutyrate Therapy for Pyruvate Dehydrogenase Complex Deficiency and Lactic Acidosis publication-title: SCIENCE TRANSLATIONAL MEDICINE contributor: fullname: Ferriero, R – volume: 144 start-page: 626 year: 2007 ident: WOS:000253198700034 article-title: Expression of NMDA receptors in multipotent stromal cells of human adipose tissue under conditions of retinoic acid-induced differentiation publication-title: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE doi: 10.1007/s10517-007-0390-6 contributor: fullname: Kulikov, AV – volume: 68 start-page: 598 year: 2001 ident: WOS:000166994200005 article-title: Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia publication-title: AMERICAN JOURNAL OF HUMAN GENETICS contributor: fullname: Slaugenhaupt, SA – volume: 78 start-page: 2418 year: 1956 ident: WOS:A1956WB83400021 article-title: POTENTIAL PURINE ANTAGONISTS .2. SYNTHESIS OF SOME 7-SUBSTITUTED PYRAZOLO(4,3-D)PYRIMIDINES AND 5,7-SUBSTITUTED PYRAZOLO[4,3-D]PYRIMIDINES publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY contributor: fullname: ROBINS, RK – volume: 20 start-page: 140 year: 2017 ident: WOS:000393920900006 article-title: Neuroprotective Effect of Halophyte Salicornia herbacea L. Is Mediated by Activation of Heme Oxygenase-1 in Mouse Hippocampal HT22 Cells publication-title: JOURNAL OF MEDICINAL FOOD doi: 10.1089/jmf.2016.3829 contributor: fullname: Kim, MS – volume: 185 start-page: ARTN 111806 year: 2020 ident: WOS:000503099900027 article-title: Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2019.111806 contributor: fullname: Borkova, L – volume: 150 start-page: 1 year: 2018 ident: WOS:000435623400001 article-title: Design, synthesis and perception of fluorescently labeled isoprenoid cytokinins publication-title: PHYTOCHEMISTRY doi: 10.1016/j.phytochem.2018.02.015 contributor: fullname: Kubiasova, K – volume: 152 start-page: 2742 year: 2011 ident: WOS:000291925700023 article-title: Estrogen Protection in Friedreich's Ataxia Skin Fibroblasts publication-title: ENDOCRINOLOGY doi: 10.1210/en.2011-0184 contributor: fullname: Richardson, TE – volume: 12 start-page: 527 year: 2009 ident: WOS:000271137200003 article-title: Cytokinin action in plant development publication-title: CURRENT OPINION IN PLANT BIOLOGY doi: 10.1016/j.pbi.2009.07.002 contributor: fullname: Werner, T – volume: 28 start-page: 736 year: 2009 ident: WOS:000270022800002 article-title: NOVEL ISOPENTENYLADENOSINE ANALOGUES: SYNTHESIS, CHARACTERIZATION, AND EVALUATION OF ANTIPROLIFERATIVE ACTIVITY ON BLADDER CARCINOMA CELLS publication-title: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS doi: 10.1080/15257770903155550 contributor: fullname: Ottria, R – volume: 16 start-page: 558 year: 2014 ident: WOS:000343026800007 article-title: Directed Solid-Phase Synthesis of Trisubstituted Imidazo[4,5-c]pyridines and Imidazo[4,5-b]pyridines publication-title: ACS COMBINATORIAL SCIENCE doi: 10.1021/co500090t contributor: fullname: Lemrova, B – volume: 16 start-page: 285 year: 2003 ident: WOS:000178549300006 article-title: Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids publication-title: BIOMETALS contributor: fullname: Ali, A – volume: 46 start-page: 27 year: 2001 ident: WOS:000167611100003 article-title: Caco-2 monolayers in experimental and theoretical predictions of drug transport (Reprinted from Advanced Drug Delivery Reviews, vol 22, pg 67-84, 1996) publication-title: ADVANCED DRUG DELIVERY REVIEWS contributor: fullname: Artursson, P – volume: 185 start-page: 111806 year: 2020 ident: 10.1016/j.bmc.2021.115993_b0180 article-title: Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid publication-title: Eur J Med Chem doi: 10.1016/j.ejmech.2019.111806 contributor: fullname: Borková – volume: 68 start-page: 598 year: 2001 ident: 10.1016/j.bmc.2021.115993_b0275 article-title: Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia publication-title: Am J Hum Genet doi: 10.1086/318810 contributor: fullname: Slaugenhaupt – volume: 460 start-page: 487 year: 2003 ident: 10.1016/j.bmc.2021.115993_b0160 article-title: Expression of Prox1 defines regions of the avian otocyst that give rise to sensory or neural cells publication-title: J Comp Neurol doi: 10.1002/cne.10662 contributor: fullname: Stone – volume: 7 start-page: 402 year: 2003 ident: 10.1016/j.bmc.2021.115993_b0280 article-title: Profiling drug-like properties in discovery research publication-title: Curr Opin Chem Biol doi: 10.1016/S1367-5931(03)00055-3 contributor: fullname: Di – volume: 126 start-page: 43 year: 2013 ident: 10.1016/j.bmc.2021.115993_b0240 article-title: Frataxin: a protein in search for a function publication-title: J Neurochem doi: 10.1111/jnc.12220 contributor: fullname: Pastore – volume: 18 start-page: 614 year: 2010 ident: 10.1016/j.bmc.2021.115993_b0030 article-title: Modulation of aberrant NF1 pre-mRNA splicing by kinetin treatment publication-title: Eur J Hum Genet doi: 10.1038/ejhg.2009.212 contributor: fullname: Pros – volume: 16 start-page: 285 year: 2003 ident: 10.1016/j.bmc.2021.115993_b0245 article-title: Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids publication-title: Biometals doi: 10.1023/A:1020642808437 contributor: fullname: Ali – volume: 150 start-page: 1 year: 2018 ident: 10.1016/j.bmc.2021.115993_b0145 article-title: Design, synthesis and perception of fluorescently labeled isoprenoid cytokinins publication-title: Phytochemistry doi: 10.1016/j.phytochem.2018.02.015 contributor: fullname: Kubiasová – volume: 3 start-page: 1 year: 2017 ident: 10.1016/j.bmc.2021.115993_b0260 article-title: MPP+ induces necrostatin-1-and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells publication-title: Cell Death Discov doi: 10.1038/cddiscovery.2017.13 contributor: fullname: Ito – volume: 144 start-page: 626 year: 2007 ident: 10.1016/j.bmc.2021.115993_b0265 article-title: Expression of NMDA receptors in multipotent stromal cells of human adipose tissue under conditions of retinoic acid-induced differentiation publication-title: Bull Exp Biol Med doi: 10.1007/s10517-007-0390-6 contributor: fullname: Kulikov – volume: 20 start-page: 140 year: 2017 ident: 10.1016/j.bmc.2021.115993_b0170 article-title: Neuroprotective effect of halophyte Salicornia herbacea L. is mediated by activation of heme oxygenase-1 in mouse hippocampal HT22 cells publication-title: J Med Food doi: 10.1089/jmf.2016.3829 contributor: fullname: Kim – volume: 13 start-page: 672 year: 2013 ident: 10.1016/j.bmc.2021.115993_b0085 article-title: N6-Isopentenyladenosine and its analogue n6-benzyladenosine induce cell cycle arrest and apoptosis in bladder carcinoma T24 cells publication-title: Anticancer Agents Med Chem doi: 10.2174/1871520611313040016 contributor: fullname: Castiglioni – volume: 28 start-page: 736 year: 2009 ident: 10.1016/j.bmc.2021.115993_b0070 article-title: Novel isopentenyladenosine analogues: synthesis, characterization, and evaluation of antiproliferative activity on bladder carcinoma cells publication-title: Nucleosides Nucleotides Nucleic Acids doi: 10.1080/15257770903155550 contributor: fullname: Ottria – volume: 13 start-page: 12 year: 2012 ident: 10.1016/j.bmc.2021.115993_b0225 article-title: R- and S-Equol have equivalent cytoprotective effects in Friedreich’s Ataxia publication-title: BMC Pharmacol Toxicol. doi: 10.1186/2050-6511-13-12 contributor: fullname: Richardson – volume: 150 start-page: 946 year: 2018 ident: 10.1016/j.bmc.2021.115993_b0110 article-title: New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress publication-title: Eur J Med Chem doi: 10.1016/j.ejmech.2018.03.043 contributor: fullname: Hönig – year: 2019 ident: 10.1016/j.bmc.2021.115993_b0120 contributor: fullname: de Roulet – volume: 12 start-page: 1 year: 2017 ident: 10.1016/j.bmc.2021.115993_b0250 article-title: The SH-SY5Y cell line in Parkinson’s disease research: a systematic review publication-title: Mol Neurodegener doi: 10.1186/s13024-017-0149-0 contributor: fullname: Xicoy – volume: 4 start-page: 1 year: 2017 ident: 10.1016/j.bmc.2021.115993_b0215 article-title: Friedreich Ataxia: current status and future prospects publication-title: Cerebellum Ataxias doi: 10.1186/s40673-017-0062-x contributor: fullname: Bürk – volume: 75 year: 2018 ident: 10.1016/j.bmc.2021.115993_b0090 article-title: Synthesis of Cytokinins via Enzymatic Arsenolysis of purine nucleosides publication-title: Curr Protoc Nucleic Acid Chem doi: 10.1002/cpnc.61 contributor: fullname: Oslovsky – volume: 88 start-page: 28 year: 1999 ident: 10.1016/j.bmc.2021.115993_b0185 article-title: MDCK (Madin-Darby Canine Kidney) cells: a tool for membrane permeability screening publication-title: J Pharm Sci doi: 10.1021/js9803205 contributor: fullname: Irvine – volume: 12 start-page: 2087 year: 1973 ident: 10.1016/j.bmc.2021.115993_b0135 article-title: Influence of alterations in the purine ring on biological activity of cytokinins publication-title: Phytochemistry doi: 10.1016/0031-9422(73)85105-2 contributor: fullname: Rogozińska – volume: 112 start-page: 2764 year: 2015 ident: 10.1016/j.bmc.2021.115993_b0100 article-title: Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia publication-title: PNAS doi: 10.1073/pnas.1415525112 contributor: fullname: Yoshida – year: 2020 ident: 10.1016/j.bmc.2021.115993_b0115 contributor: fullname: Slaugenhaupt – volume: 55 start-page: 100958 year: 2019 ident: 10.1016/j.bmc.2021.115993_b0010 article-title: The plant hormone kinetin in disease therapy and healthy aging publication-title: Age Res Rev doi: 10.1016/j.arr.2019.100958 contributor: fullname: Kadlecová – volume: 78 start-page: 2418 year: 1956 ident: 10.1016/j.bmc.2021.115993_b0150 article-title: Potential purine antagonists. II. Synthesis of some 7- and 5,7-substituted pyrazolo [4,3-d]pyrimidines publication-title: J Am Chem Soc doi: 10.1021/ja01592a021 contributor: fullname: Robins – volume: 6 year: 2017 ident: 10.1016/j.bmc.2021.115993_b0005 article-title: Plant hormone cytokinins for modulating human aging and age-related diseases doi: 10.1007/978-3-319-63001-4_14 contributor: fullname: Voller – volume: 18 start-page: 8396 year: 2010 ident: 10.1016/j.bmc.2021.115993_b0075 article-title: N6-Alkyladenosines: synthesis and evaluation of in vitro anticancer activity publication-title: Bioorg Med Chem doi: 10.1016/j.bmc.2010.09.030 contributor: fullname: Ottria – volume: 10 year: 2019 ident: 10.1016/j.bmc.2021.115993_b0155 article-title: Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin publication-title: Nat Commun doi: 10.1038/s41467-019-11470-9 contributor: fullname: Gervason – volume: 310 start-page: 627 year: 2003 ident: 10.1016/j.bmc.2021.115993_b0175 article-title: EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2003.09.019 contributor: fullname: Anderson – volume: 24 start-page: 57 year: 2019 ident: 10.1016/j.bmc.2021.115993_b0105 article-title: Development of a screening platform to identify small molecules that modify ELP1 Pre-mRNA splicing in familial dysautonomia publication-title: SLAS Disc: Adv Sci Drug Disc doi: 10.1177/2472555218792264 contributor: fullname: Salani – year: 1997 ident: 10.1016/j.bmc.2021.115993_b0020 article-title: A mechanism for the in vivo formation of N6-furfuryladenine, kinetin, as a secondary oxidative damage product of DNA publication-title: FEBS Lett contributor: fullname: Barciszewski – volume: 4 start-page: 1 year: 2001 ident: 10.1016/j.bmc.2021.115993_b0195 article-title: PAST: paleontological statistics software package for education and data analysis publication-title: Palaeontol Electron contributor: fullname: Hammer – start-page: 765 year: 1960 ident: 10.1016/j.bmc.2021.115993_b0130 article-title: Potential purine antagonists. XXIII. Synthesis of some 7-substituted amino-v-triazolo(d)pyrimidines1 publication-title: J Org Chem doi: 10.1021/jo01075a023 contributor: fullname: Weiss – volume: 149 start-page: 161 year: 2018 ident: 10.1016/j.bmc.2021.115993_b0140 article-title: Cytokinin activity of N6-benzyladenine derivatives assayed by interaction with the receptors in planta, in vitro, and in silico publication-title: Phytochemistry doi: 10.1016/j.phytochem.2018.02.008 contributor: fullname: Savelieva – volume: 144 start-page: 716 year: 2018 ident: 10.1016/j.bmc.2021.115993_b0210 article-title: Novel non-sulfonamide 5-HT 6 receptor partial inverse agonist in a group of imidazo[4,5- b ]pyridines with cognition enhancing properties publication-title: Eur J Med Chem doi: 10.1016/j.ejmech.2017.12.053 contributor: fullname: Vanda – volume: 20 start-page: 954 year: 2010 ident: 10.1016/j.bmc.2021.115993_b0200 article-title: Statistical inference for tumor growth inhibition T/C ratio publication-title: J Biopharm Stat doi: 10.1080/10543401003618983 contributor: fullname: Wu – volume: 29 start-page: 124 year: 2015 ident: 10.1016/j.bmc.2021.115993_b0235 article-title: Cell viability assessment using the Alamar blue assay: a comparison of 2D and 3D cell culture models publication-title: Toxicol In Vitro doi: 10.1016/j.tiv.2014.09.014 contributor: fullname: Bonnier – volume: 28 start-page: 115230 year: 2020 ident: 10.1016/j.bmc.2021.115993_b0095 article-title: New aromatic 6-substituted 2′-deoxy-9-(β)-d-ribofuranosylpurine derivatives as potential plant growth regulators publication-title: Bioorg Med Chem doi: 10.1016/j.bmc.2019.115230 contributor: fullname: Matušková – volume: 5 year: 2013 ident: 10.1016/j.bmc.2021.115993_b0230 article-title: Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3004986 contributor: fullname: Ferriero – volume: 1 start-page: 95 year: 2008 ident: 10.1016/j.bmc.2021.115993_b0270 article-title: Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y publication-title: BMC Res Notes doi: 10.1186/1756-0500-1-95 contributor: fullname: Nishida – volume: 34 start-page: 1064 year: 2003 ident: 10.1016/j.bmc.2021.115993_b0165 article-title: One-step cellular caspase-3/7 assay publication-title: Biotechniques doi: 10.2144/03345dd02 contributor: fullname: Carrasco – volume: 70 start-page: 480 year: 2011 ident: 10.1016/j.bmc.2021.115993_b0035 article-title: Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia publication-title: Pediatr Res doi: 10.1203/PDR.0b013e31822e1825 contributor: fullname: Axelrod – volume: 2 start-page: 549 year: 2012 ident: 10.1016/j.bmc.2021.115993_b0285 article-title: Preclinical experimental models of drug metabolism and disposition in drug discovery and development publication-title: Acta Pharmaceutica Sinica B doi: 10.1016/j.apsb.2012.10.004 contributor: fullname: Zhang – volume: 8 year: 2013 ident: 10.1016/j.bmc.2021.115993_b0080 article-title: N6-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1. Fraidenraich D, ed. publication-title: PLoS One doi: 10.1371/journal.pone.0080755 contributor: fullname: Amiable – volume: 16 start-page: 558 year: 2014 ident: 10.1016/j.bmc.2021.115993_b0205 article-title: Directed solid-phase synthesis of trisubstituted imidazo[4,5- c ]pyridines and imidazo[4,5- b ]pyridines publication-title: ACS Comb. Sci. doi: 10.1021/co500090t contributor: fullname: Lemrová – volume: 152 start-page: 2742 year: 2011 ident: 10.1016/j.bmc.2021.115993_b0220 article-title: Estrogen protection in Friedreich’s Ataxia skin fibroblasts publication-title: Endocrinology doi: 10.1210/en.2011-0184 contributor: fullname: Richardson – volume: 13 start-page: 429 year: 2004 ident: 10.1016/j.bmc.2021.115993_b0025 article-title: Rescue of a human mRNA splicing defect by the plant cytokinin kinetin publication-title: Hum Mol Genet doi: 10.1093/hmg/ddh046 contributor: fullname: Slaugenhaupt – volume: 81 start-page: 547 year: 2015 ident: 10.1016/j.bmc.2021.115993_b0295 article-title: Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin publication-title: Indian J Dermatol Venereol Leprol doi: 10.4103/0378-6323.157446 contributor: fullname: Wanitphakdeedecha – volume: 201 start-page: 665 year: 1994 ident: 10.1016/j.bmc.2021.115993_b0015 article-title: Kinetin delays the onset of ageing characteristics in human fibroblasts publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1994.1752 contributor: fullname: Rattan – volume: 154 start-page: 737 year: 2013 ident: 10.1016/j.bmc.2021.115993_b0045 article-title: A neo-substrate that amplifies catalytic activity of parkinson’s-disease- related kinase PINK1 publication-title: Cell doi: 10.1016/j.cell.2013.07.030 contributor: fullname: Hertz – volume: 115 start-page: E7081 year: 2018 ident: 10.1016/j.bmc.2021.115993_b0050 article-title: N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation publication-title: PNAS doi: 10.1073/pnas.1801772115 contributor: fullname: Bowie – volume: 46 start-page: 27 year: 2001 ident: 10.1016/j.bmc.2021.115993_b0190 article-title: Caco-2 monolayers in experimental and theoretical predictions of drug transport publication-title: Adv Drug Deliv Rev doi: 10.1016/S0169-409X(00)00128-9 contributor: fullname: Artursson – volume: 15 start-page: 3737 year: 2007 ident: 10.1016/j.bmc.2021.115993_b0060 article-title: Preparation, biological activity and endogenous occurrence of N6-benzyladenosines publication-title: Bioorg Med Chem doi: 10.1016/j.bmc.2007.03.038 contributor: fullname: Doležal – start-page: 131 year: 1960 ident: 10.1016/j.bmc.2021.115993_b0125 article-title: 26. Pyrrolo[2,3-d]pyrimidines publication-title: J Chem Soc doi: 10.1039/jr9600000131 contributor: fullname: Davoll – volume: 124 start-page: 2179 year: 2009 ident: 10.1016/j.bmc.2021.115993_b0065 article-title: Pharmacogenomics and analogues of the antitumour agent N 6 -isopentenyladenosine publication-title: Int J Cancer doi: 10.1002/ijc.24168 contributor: fullname: Colombo – volume: 9 start-page: 91 year: 2015 ident: 10.1016/j.bmc.2021.115993_b0255 article-title: Researching glutamate – induced cytotoxicity in different cell lines: a comparative/collective analysis/study publication-title: Front Cell Neurosci doi: 10.3389/fncel.2015.00091 contributor: fullname: Kritis – volume: 14 year: 2019 ident: 10.1016/j.bmc.2021.115993_b0040 article-title: Combinatorial treatment increases IKAP levels in human cells generated from Familial Dysautonomia patients publication-title: PLoS One doi: 10.1371/journal.pone.0211602 contributor: fullname: Yannai – volume: 10 year: 2015 ident: 10.1016/j.bmc.2021.115993_b0290 article-title: A new PAMPA model proposed on the basis of a synthetic phospholipid membrane. Hofmann A, ed. publication-title: PLoS One contributor: fullname: Yu – volume: 12 start-page: 527 year: 2009 ident: 10.1016/j.bmc.2021.115993_b0055 article-title: Cytokinin action in plant development publication-title: Curr Opin Plant Biol doi: 10.1016/j.pbi.2009.07.002 contributor: fullname: Werner |
| SSID | ssj0002491 |
| Score | 2.406181 |
| Snippet | [Display omitted]
Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related... Kinetin (N-6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal... Kinetin (N -furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal... Kinetin (N6-furfuryladenine), a plant growth substance of the cytokinin family, has been shown to modulate aging and various age-related conditions in animal... |
| Source | Web of Science |
| SourceID | hal proquest crossref pubmed webofscience elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 115993 |
| SubjectTerms | Biochemistry & Molecular Biology bioisostery – Friedreich́s ataxia Chemistry Chemistry, Medicinal Chemistry, Organic Cytokinin Kinetin Life Sciences Life Sciences & Biomedicine Mitoprotection – familial dysautonomia Neuroprotection Pharmacology & Pharmacy Physical Sciences Science & Technology |
| Title | Cytoprotective activities of kinetin purine isosteres |
| URI | https://dx.doi.org/10.1016/j.bmc.2021.115993 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000623635000002 https://www.ncbi.nlm.nih.gov/pubmed/33497938 https://search.proquest.com/docview/2481643951 https://hal.science/hal-03141631 |
| Volume | 33 |
| WOS | 000623635000002 |
| WOSCitedRecordID | wos000623635000002 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB51txJwQbDlsUCrgCoOSGHjVxIfV1Gr5dFeoFJvVvwSC2p21aaVeulvZ5w4KyooQhzjTJx4JvrmG3s8BtjXUgrPTJl6KnWK_Jan0tY0rYklWU2MYTbsRj46zhcn_OOpON2CatgLE9IqI_b3mN6hdWyZRW3O1svl7AuS7zIrZU77KepyBNvojjgfw_b8w6fF8QaQMcLoDs5D-TQ8MCxudmle-iwUMqQEsUNIye5yT6NvIU_ydxL6R3_V-abDR_Awkspk3n_3Y9hyzQR25g0G1GfXydukS_Ps5s8ncL8ajnibwL2juLK-A6K6blexaAMCYBL2O1x11VaTlU9-oEy7bJJ1mJt3yfIibA3BQP0JnBwefK0WaTxSITWsLNqUaG0xImQuqy0VmjKvkeGVthB15jIr8tog-lmkjZ44abX0MqOG8cIIlnFt2FMYN6vGPYfE5i5j0nuf8YKbHHuWtSHCOotvKgidwrtBk2rdV85QQ0rZd4VqV0Htqlf7FPiga3XL_AqR_W-PvUG7bLoPpbIX888qtIWy_Mg1yRWZwuvBbAr1GxZE6satLi8U5SUJjEygzLPenpu-GOMSsaucwv6vBt7cD36eMqRrXZiFoyX_IlbFwuuh4ED74v8G_RIehKs-Ee4VjNvzS7eLzKjVezB6f0P24v__E-d_CLw |
| link.rule.ids | 230,315,786,790,891,4521,24144,27957,27958,45620,45714 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Za9tAEB4SB5q8lNbp4Z5qCX0oCGsvSftoRIPS2H5pAnlbtIeIWyKbRAnk33dWWpmWHpS-ag9pZ9A33-zOzAIcaSlFzUwe11TqGPktj6WtaFwRS5KKGMOsz0ZeLNPynH--EBc7UAy5MD6sMmB_j-kdWocn0yDN6Wa1mn5B8p0nuUxpv0Wd78IeFxnhI9ibnZyWyy0go4fRXZyH_WM_YDjc7MK89JUvZEgJYoeQkv3JPO1e-jjJX0nob-1VZ5uOH8HDQCqjWf_dj2HHNWM4nDXoUF_dRx-iLsyz2z8fw34xXPE2hgeLcLJ-CKK4b9ehaAMCYOTzHe66aqvRuo6-YZ921UQbvzfvotWNTw1BR_0JnB9_OivKOFypEBuWZ21MtLboETKXVJYKTVmtkeHlNhNV4hIr0sog-lmkjTVx0mpZy4QaxjMjWMK1YU9h1Kwb9xwim7qEybquE55xk-LMsjJEWGfxTRmhE_g4SFJt-soZaggp-6pQ7MqLXfVinwAfZK1-Ur9CZP_bsPeol-30vlR2OZsr_8yX5UeuSe7IBN4NalMoX38gUjVufXujKM-JZ2QC-zzr9bmdizEuEbvyCRz9qOBtu7fzlCFd69wsXC35l25FKLzuCw60L_5v0W9hvzxbzNX8ZHn6Eg58Sx8U9wpG7fWte40sqdVvwl_wHUeLCq4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cytoprotective+activities+of+kinetin+purine+isosteres&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.au=Makova%2C+Barbara&rft.au=Mik%2C+Vaclav&rft.au=Liskova%2C+Barbora&rft.au=Gonzalez%2C+Gabriel&rft.date=2021-03-01&rft.pub=Elsevier&rft.issn=0968-0896&rft.eissn=1464-3391&rft.volume=33&rft_id=info:doi/10.1016%2Fj.bmc.2021.115993&rft_id=info%3Apmid%2F33497938&rft.externalDBID=n%2Fa&rft.externalDocID=000623635000002 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0968-0896&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0968-0896&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0968-0896&client=summon |