Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1

• Published in: Investigative ophthalmology & visual science Vol. 59; no. 7; pp. 3053 - 3057
• Main Authors: Winkler, Nelson S., Milone, Margherita, Martinez-Thompson, Jennifer M., Raja, Harish, Aleff, Ross A., Patel, Sanjay V., Fautsch, Michael P., Wieben, Eric D., Baratz, Keith H.
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 01.06.2018
• Subjects: Cornea

RNA toxicity from CTG trinucleotide repeat (TNR) expansion within noncoding DNA of the transcription factor 4 (TCF4) and DM1 protein kinase (DMPK) genes has been described in Fuchs' endothelial corneal dystrophy (FECD) and myotonic dystrophy, type 1 (DM1), respectively. We prospectively evaluat...