NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway

• Published in: DNA and cell biology Vol. 39; no. 3; p. 368
• Main Authors: Li, Anmao, Li, Xingxin, Chen, Xuanxin, Zeng, Chensi, Wang, Zuo, Li, Zhen, Chen, Jianbin
• Format: Journal Article
• Language: English
• Published: United States 01.03.2020
• Subjects: Adenine - analogs & derivatives; Adenine - pharmacology; Apoptosis; Autophagy; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Bone Marrow Cells - drug effects; Bone Marrow Cells - metabolism; Cell Line, Tumor; Chloroquine - pharmacology; Gene Silencing; Humans; Multiple Myeloma - genetics; Multiple Myeloma - metabolism; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; TOR Serine-Threonine Kinases - metabolism; apoptosis; multiple myeloma; PI3K/AKT/mTOR pathway; autophagy; NUPR1

Nuclear protein 1 (NUPR1) is a stress-related small molecule and plays important roles in various tumors, including multiple myeloma (MM). Autophagy is essential for maintaining cellular homoeostasis in response to stress and, together with apoptosis, determines cell fate. Previous studies indicate...