Use of a Two-Gene Methylated DNA Biomarker Assay and Nonendoscopic Balloon for Detection of Barrett Esophagus Among High-Risk Individuals in a Screening Population

• Published in: The American journal of gastroenterology Vol. 120; no. 7; pp. 1511 - 1520
• Main Authors: Shaheen, Nicholas J., Othman, Mohamed O., Taunk, Jawar, Chang, Kenneth J., Jaganmohan, Sathya, Yachimski, Patrick S., Fang, John C., Spataro, Joseph S., Verma, Suman, Lee, Victoria T., deGuzman, Brian J., Aklog, Lishan
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Wolters Kluwer 01.07.2025; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - genetics; Aged; Barrett Esophagus - diagnosis; Barrett Esophagus - genetics; Barrett Esophagus - pathology; Biomarkers; Biopsy; DNA Methylation; Endoscopy; Endoscopy, Digestive System; Esophageal cancer; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - genetics; Esophagus; Gastroenterology; Gastroesophageal reflux; Gastroesophageal Reflux - complications; Health risks; Humans; Male; Medical screening; Middle Aged; Mortality; Prospective Studies; Risk Factors; Tobacco; United States > US; GERD; EsoGuard; esophageal adenocarcinoma; nonendoscopic screening; Barrett esophagus; EsoCheck; clinical validity

INTRODUCTION:Barrett esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC). We aimed to assess performance, safety, and tolerability of the EsoGuard (EG) assay on samples collected nonendoscopically with the EsoCheck (EC) device (EG/EC) for BE detection in the intended-use population me...