Modification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a sub‐lethal doses of the insecticide fipronil
Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized Apis mellifera worke...
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| Published in | Ecotoxicology (London) Vol. 23; no. 9; pp. 1659 - 1670 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Boston
Springer US
01.11.2014
Springer Springer Nature B.V |
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| Abstract | Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized
Apis mellifera
workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e.
1
/
100
of LD
50
/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees. |
|---|---|
| AbstractList | Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized
Apis mellifera
workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e.
1
/
100
of LD
50
/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees. Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized Apis mellifera workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e. .sup.1/.sub.100 of LD.sub.50/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees. Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized Apis mellifera workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e. ^sup 1^/^sub 100^ of LD^sub 50^/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees.[PUBLICATION ABSTRACT] Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized Apis mellifera workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e. (1)/100 of LD50/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees. |
| Audience | Academic |
| Author | Santos, K. S. Malaspina, O. dos Santos, L. D. Palma, M. S. Roat, T. C. dos Santos-Pinto, J. R. A. |
| Author_xml | – sequence: 1 givenname: T. C. surname: Roat fullname: Roat, T. C. email: thaisaroat@yahoo.com.br organization: Institute of Biosciences of Rio Claro, Department of Biology, Center of the Study of Social Insects, University of São Paulo State (UNESP) – sequence: 2 givenname: J. R. A. surname: dos Santos-Pinto fullname: dos Santos-Pinto, J. R. A. organization: Institute of Biosciences of Rio Claro, Department of Biology, Center of the Study of Social Insects, University of São Paulo State (UNESP) – sequence: 3 givenname: L. D. surname: dos Santos fullname: dos Santos, L. D. organization: Center for the Study of Venoms and Venomous Animals (CEVAP), University of São Paulo State (UNESP) – sequence: 4 givenname: K. S. surname: Santos fullname: Santos, K. S. organization: Discipline of Allergy and Immunology (HC/Incor/FMUSP) – sequence: 5 givenname: O. surname: Malaspina fullname: Malaspina, O. organization: Institute of Biosciences of Rio Claro, Department of Biology, Center of the Study of Social Insects, University of São Paulo State (UNESP) – sequence: 6 givenname: M. S. surname: Palma fullname: Palma, M. S. organization: Institute of Biosciences of Rio Claro, Department of Biology, Center of the Study of Social Insects, University of São Paulo State (UNESP) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25139030$$D View this record in MEDLINE/PubMed |
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| Keywords | Phenylpyrazole Proteomic analysis Insecticide 2-DE Brain proteome Mass spectrometry |
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| Snippet | Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies... |
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| SubjectTerms | Analysis Animals Bees Brain - drug effects Brain - metabolism Brain damage Brazil Earth and Environmental Science Ecology Ecotoxicology Environment Environmental Management Honeybee Insecticides Insecticides - toxicity Lethal Dose 50 Proteins Proteome - drug effects Pyrazoles - toxicity Toxicity Tests, Subacute |
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| Title | Modification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a sub‐lethal doses of the insecticide fipronil |
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