Determination of the concentration of gilteritinib in human plasma using HPLC

• Published in: Biomedical chromatography Vol. 35; no. 4; pp. e5028 - n/a
• Main Authors: Yasu, Takeo, Sugi, Tomiyuki, Momo, Kenji, Hagihara, Masao, Yasui, Hiroshi
• Format: Journal Article
• Language: English
• Published: England 01.04.2021
• Subjects: acute myeloid leukemia; gilteritinib; HPLC‐UV; human plasma; gilteritinib; acute myeloid leukemia; HPLC-UV; human plasma

Gilteritinib, an oral inhibitor of FMS‐like tyrosine kinase 3 (FLT3), is a standard treatment for FLT3‐mutated acute myeloid leukemia. We developed a simple HPLC‐UV‐based method for determining the concentration of gilteritinib in human plasma. The analysis requires the extraction of a 200‐μL plasma...