The interaction of human dendritic cells with yeast and germ-tube forms of Candida albicans leads to efficient fungal processing, dendritic cell maturation, and acquisition of a Th1 response-promoting function

• Published in: Journal of leukocyte biology Vol. 75; no. 1; pp. 117 - 126
• Main Authors: Romagnoli, G., Nisini, R., Chiani, P., Mariotti, S., Teloni, R., Cassone, A., Torosantucci, A.
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01.01.2004
• Subjects: antifungal immunity; Antigen-Presenting Cells - immunology; APC; Candida albicans; Candida albicans - pathogenicity; Candida albicans - physiology; Cell Differentiation - physiology; Cells, Cultured; Coculture Techniques; Culture Media; Cytokines - secretion; Dendritic Cells - cytology; Dendritic Cells - immunology; Dendritic Cells - microbiology; dimorphism; Flow Cytometry - methods; Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology; Humans; phagocytosis; Phagocytosis - physiology; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes - immunology; Th1 Cells - immunology; Th1 Cells - microbiology

T helper cell type 1 (Th1) cell‐mediated immunity plays a rical role in protection against the opportunistic pathogen Candida albicans. Virulence of the fungus is closely associated with its ability to form germ‐tubes (GT), the early phase of the dimorphic transition from the commensal yeast (Y) to...