Prognostic significance of visceral obesity in patients with advanced renal cell carcinoma undergoing nephrectomy

Objectives To determine the effect of visceral obesity on the prognosis of advanced renal cell carcinoma patients undergoing nephrectomy. Methods We reviewed clinicopathological data of 2187 patients who underwent nephrectomy for renal cell carcinoma (localized [T1–2, N0, M0], n = 1738 [79.5%]; adva...

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Published inInternational journal of urology Vol. 22; no. 5; pp. 455 - 461
Main Authors Lee, Hye Won, Jeong, Byong Chang, Seo, Seong Il, Jeon, Seong Soo, Lee, Hyun Moo, Choi, Han Yong, Jeon, Hwang Gyun
Format Journal Article
LanguageEnglish
Published Australia Blackwell Publishing Ltd 01.05.2015
Subjects
abdominal
Adult
Aged
Body Mass Index
carcinoma
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - surgery
Female
Humans
Kidney Neoplasms - diagnosis
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Nephrectomy
obesity
Obesity, Abdominal - physiopathology
Prognosis
renal cell
Republic of Korea
Retrospective Studies
Risk Factors
Republic of Korea
renal cell
abdominal
nephrectomy
carcinoma
prognosis
obesity
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Abstract Objectives To determine the effect of visceral obesity on the prognosis of advanced renal cell carcinoma patients undergoing nephrectomy. Methods We reviewed clinicopathological data of 2187 patients who underwent nephrectomy for renal cell carcinoma (localized [T1–2, N0, M0], n = 1738 [79.5%]; advanced [T3–4, any N and M], n = 449 [20.5%]) at Samsung Medical Center, Seoul, Korea. The visceral fat area and subcutaneous fat area were determined at the level of the umbilicus on computed tomograms obtained before surgery. Patients were categorized as either viscerally obese or non‐obese according to visceral fat area and visceral fat area/subcutaneous fat area ratio. Results High visceral fat area (greater than 50 percentiles in each sex) was associated with longer cancer‐specific survival (P = 0.01) or overall survival (P = 0.03), whereas visceral fat area/subcutaneous fat area ratio showed no influence on survival outcomes. By multivariate analysis adjusted with clinicopathological variables, low visceral fat area was an independent predictor of cancer‐specific death and overall death (cancer‐specific survival P = 0.004, hazard ratio = 2.19; overall survival P = 0.003, hazard ratio = 2.22), as well as old age (P = 0.01), radical nephrectomy (P = 0.002), high tumor grade (P = 0.01) and the presence of a sarcomatoid component (P < 0.001) in the subgroup analysis of advanced renal cell carcinoma. Conclusion High visceral fat area might represent a predictor of better prognosis in patients with advanced renal cell carcinomas undergoing nephrectomy. © 2015 The Japanese Urological Association
AbstractList OBJECTIVESTo determine the effect of visceral obesity on the prognosis of advanced renal cell carcinoma patients undergoing nephrectomy.METHODSWe reviewed clinicopathological data of 2187 patients who underwent nephrectomy for renal cell carcinoma (localized [T1-2, N0, M0], n = 1738 [79.5%]; advanced [T3-4, any N and M], n = 449 [20.5%]) at Samsung Medical Center, Seoul, Korea. The visceral fat area and subcutaneous fat area were determined at the level of the umbilicus on computed tomograms obtained before surgery. Patients were categorized as either viscerally obese or non-obese according to visceral fat area and visceral fat area/subcutaneous fat area ratio.RESULTSHigh visceral fat area (greater than 50 percentiles in each sex) was associated with longer cancer-specific survival (P = 0.01) or overall survival (P = 0.03), whereas visceral fat area/subcutaneous fat area ratio showed no influence on survival outcomes. By multivariate analysis adjusted with clinicopathological variables, low visceral fat area was an independent predictor of cancer-specific death and overall death (cancer-specific survival P = 0.004, hazard ratio = 2.19; overall survival P = 0.003, hazard ratio = 2.22), as well as old age (P = 0.01), radical nephrectomy (P = 0.002), high tumor grade (P = 0.01) and the presence of a sarcomatoid component (P < 0.001) in the subgroup analysis of advanced renal cell carcinoma.CONCLUSIONHigh visceral fat area might represent a predictor of better prognosis in patients with advanced renal cell carcinomas undergoing nephrectomy.
Objectives To determine the effect of visceral obesity on the prognosis of advanced renal cell carcinoma patients undergoing nephrectomy. Methods We reviewed clinicopathological data of 2187 patients who underwent nephrectomy for renal cell carcinoma (localized [T1–2, N0, M0], n = 1738 [79.5%]; advanced [T3–4, any N and M], n = 449 [20.5%]) at Samsung Medical Center, Seoul, Korea. The visceral fat area and subcutaneous fat area were determined at the level of the umbilicus on computed tomograms obtained before surgery. Patients were categorized as either viscerally obese or non‐obese according to visceral fat area and visceral fat area/subcutaneous fat area ratio. Results High visceral fat area (greater than 50 percentiles in each sex) was associated with longer cancer‐specific survival (P = 0.01) or overall survival (P = 0.03), whereas visceral fat area/subcutaneous fat area ratio showed no influence on survival outcomes. By multivariate analysis adjusted with clinicopathological variables, low visceral fat area was an independent predictor of cancer‐specific death and overall death (cancer‐specific survival P = 0.004, hazard ratio = 2.19; overall survival P = 0.003, hazard ratio = 2.22), as well as old age (P = 0.01), radical nephrectomy (P = 0.002), high tumor grade (P = 0.01) and the presence of a sarcomatoid component (P < 0.001) in the subgroup analysis of advanced renal cell carcinoma. Conclusion High visceral fat area might represent a predictor of better prognosis in patients with advanced renal cell carcinomas undergoing nephrectomy. © 2015 The Japanese Urological Association
Objectives To determine the effect of visceral obesity on the prognosis of advanced renal cell carcinoma patients undergoing nephrectomy. Methods We reviewed clinicopathological data of 2187 patients who underwent nephrectomy for renal cell carcinoma (localized [T1–2, N0, M0], n  = 1738 [79.5%]; advanced [T3–4, any N and M], n  = 449 [20.5%]) at Samsung Medical Center, Seoul, Korea. The visceral fat area and subcutaneous fat area were determined at the level of the umbilicus on computed tomograms obtained before surgery. Patients were categorized as either viscerally obese or non‐obese according to visceral fat area and visceral fat area/subcutaneous fat area ratio. Results High visceral fat area (greater than 50 percentiles in each sex) was associated with longer cancer‐specific survival ( P  = 0.01) or overall survival ( P  = 0.03), whereas visceral fat area/subcutaneous fat area ratio showed no influence on survival outcomes. By multivariate analysis adjusted with clinicopathological variables, low visceral fat area was an independent predictor of cancer‐specific death and overall death (cancer‐specific survival P  = 0.004, hazard ratio = 2.19; overall survival P  = 0.003, hazard ratio = 2.22), as well as old age ( P  = 0.01), radical nephrectomy ( P  = 0.002), high tumor grade ( P  = 0.01) and the presence of a sarcomatoid component ( P  < 0.001) in the subgroup analysis of advanced renal cell carcinoma. Conclusion High visceral fat area might represent a predictor of better prognosis in patients with advanced renal cell carcinomas undergoing nephrectomy. © 2015 The Japanese Urological Association
To determine the effect of visceral obesity on the prognosis of advanced renal cell carcinoma patients undergoing nephrectomy. We reviewed clinicopathological data of 2187 patients who underwent nephrectomy for renal cell carcinoma (localized [T1-2, N0, M0], n = 1738 [79.5%]; advanced [T3-4, any N and M], n = 449 [20.5%]) at Samsung Medical Center, Seoul, Korea. The visceral fat area and subcutaneous fat area were determined at the level of the umbilicus on computed tomograms obtained before surgery. Patients were categorized as either viscerally obese or non-obese according to visceral fat area and visceral fat area/subcutaneous fat area ratio. High visceral fat area (greater than 50 percentiles in each sex) was associated with longer cancer-specific survival (P = 0.01) or overall survival (P = 0.03), whereas visceral fat area/subcutaneous fat area ratio showed no influence on survival outcomes. By multivariate analysis adjusted with clinicopathological variables, low visceral fat area was an independent predictor of cancer-specific death and overall death (cancer-specific survival P = 0.004, hazard ratio = 2.19; overall survival P = 0.003, hazard ratio = 2.22), as well as old age (P = 0.01), radical nephrectomy (P = 0.002), high tumor grade (P = 0.01) and the presence of a sarcomatoid component (P < 0.001) in the subgroup analysis of advanced renal cell carcinoma. High visceral fat area might represent a predictor of better prognosis in patients with advanced renal cell carcinomas undergoing nephrectomy.
Author Jeong, Byong Chang
Jeon, Seong Soo
Choi, Han Yong
Seo, Seong Il
Lee, Hyun Moo
Lee, Hye Won
Jeon, Hwang Gyun
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Keywords renal cell
abdominal
nephrectomy
carcinoma
prognosis
obesity
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Snippet Objectives To determine the effect of visceral obesity on the prognosis of advanced renal cell carcinoma patients undergoing nephrectomy. Methods We reviewed...
To determine the effect of visceral obesity on the prognosis of advanced renal cell carcinoma patients undergoing nephrectomy. We reviewed clinicopathological...
OBJECTIVESTo determine the effect of visceral obesity on the prognosis of advanced renal cell carcinoma patients undergoing nephrectomy.METHODSWe reviewed...
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SubjectTerms abdominal
Adult
Aged
Body Mass Index
carcinoma
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - surgery
Female
Humans
Kidney Neoplasms - diagnosis
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Nephrectomy
obesity
Obesity, Abdominal - physiopathology
Prognosis
renal cell
Republic of Korea
Retrospective Studies
Risk Factors
Title Prognostic significance of visceral obesity in patients with advanced renal cell carcinoma undergoing nephrectomy
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https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fiju.12716
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https://search.proquest.com/docview/1680183818
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