Safety, tolerability, pharmacokinetics, and pharmacodynamic effects of naloxegol at peripheral and central nervous system receptors in healthy male subjects: A single ascending-dose study - Eldon, Michael A.; Kugler, Alan R.; Medve, Robert A.; Bui, Khanh; Butler, Kathleen; Sostek, Mark (Clinical pharmacology in drug development, 2015)
Keywords: Administration, Oral; Adolescent; Adult; Central Nervous System - drug effects; Central Nervous System - metabolism; Central Nervous System - physiopathology; chronic pain; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Gastrointestinal Transit - drug effects; Healthy Volunteers; Humans; Linear Models; Male; Middle Aged; Miosis - chemically induced; Miosis - metabolism; Miosis - physiopathology; Models, Biological; Morphinans - administration & dosage; Morphinans - adverse effects; Morphinans - pharmacokinetics; Morphine - adverse effects; Morphine - antagonists & inhibitors; naloxegol; Narcotic Antagonists - administration & dosage; Narcotic Antagonists - adverse effects; Narcotic Antagonists - pharmacokinetics; Nervous system; Netherlands; opioid-induced constipation; Peripheral Nervous System - drug effects; Peripheral Nervous System - metabolism; Peripheral Nervous System - physiopathology; pharmacokinetic/pharmacodynamic modeling; pharmacokinetics; Polyethylene Glycols - administration & dosage; Polyethylene Glycols - adverse effects; Polyethylene Glycols - pharmacokinetics; Receptors, Opioid, mu - antagonists & inhibitors; Receptors, Opioid, mu - metabolism; Young Adult; pharmacokinetics; pharmacokinetic/pharmacodynamic modeling; chronic pain; naloxegol; opioid-induced constipation