Alleviation of Neuropathic Pain by Regulating T-Type Calcium Channels in Rat Anterior Cingulate Cortex

• Published in: Molecular pain Vol. 11; no. 1; p. 8
• Main Authors: Shen, Feng-Yan, Chen, Zhi-Yu, Zhong, Wei, Ma, Li-Qing, Chen, Chong, Yang, Zhou-Jing, Xie, Wei-Lin, Wang, Ying-Wei
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 06.03.2015; Sage Publications Ltd
• Subjects: Animal models; Calcium channels; Calcium channels (T-type); Calcium channels (voltage-gated); Cortex (cingulate); Dorsal horn; Dorsal root ganglia; Excitatory postsynaptic potentials; Firing rate; Microinjection; Neuralgia; Pain; Pain perception; Central sensitization; Anterior cingulate cortex; T-type calcium channel; Neuropathic pain

Background It has been demonstrated that administration of T-type calcium channel (TCC) inhibitors could relieve the neuropathic pain by intraperitoneally or intrathecally. TCCs are not only expressed in dorsal root ganglia or dorsal horn, but also in some of the pain associated brain regions. In th...