Future Prospects of Positron Emission Tomography-Magnetic Resonance Imaging Hybrid Systems and Applications in Psychiatric Disorders

A positron emission tomography (PET)-magnetic resonance imaging (MRI) hybrid system has been developed to improve the accuracy of molecular imaging with structural imaging. However, the mismatch in spatial resolution between the two systems hinders the use of the hybrid system. As the magnetic field...

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Published inPharmaceuticals (Basel, Switzerland) Vol. 15; no. 5; p. 583
Main Authors Son, Young-Don, Kim, Young-Bo, Kim, Jong-Hoon, Kim, Jeong-Hee, Kwon, Dae-Hyuk, Lee, Haigun, Cho, Zang-Hee
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.05.2022
MDPI
Subjects
Brain research
Design
FDA approval
high resolution
hybrid imaging
Magnetic fields
Magnetic resonance imaging
Mental disorders
Physical properties
positron emission tomography
psychiatric disorders
Review
Sensors
Tomography
United States > US
magnetic resonance imaging
hybrid imaging
positron emission tomography
high resolution
psychiatric disorders
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Abstract A positron emission tomography (PET)-magnetic resonance imaging (MRI) hybrid system has been developed to improve the accuracy of molecular imaging with structural imaging. However, the mismatch in spatial resolution between the two systems hinders the use of the hybrid system. As the magnetic field of the MRI increased up to 7.0 tesla in the commercial system, the performance of the MRI system largely improved. Several technical attempts in terms of the detector and the software used with the PET were made to improve the performance. As a result, the high resolution of the PET-MRI fusion system enables quantitation of metabolism and molecular information in the small substructures of the brainstem, hippocampus, and thalamus. Many studies on psychiatric disorders, which are difficult to diagnose with medical imaging, have been accomplished using various radioligands, but only a few studies have been conducted using the PET-MRI fusion system. To increase the clinical usefulness of medical imaging in psychiatric disorders, a high-resolution PET-MRI fusion system can play a key role by providing important information on both molecular and structural aspects in the fine structures of the brain. The development of high-resolution PET-MR systems and their potential roles in clinical studies of psychiatric disorders were reviewed as prospective views in future diagnostics.
AbstractList A positron emission tomography (PET)–magnetic resonance imaging (MRI) hybrid system has been developed to improve the accuracy of molecular imaging with structural imaging. However, the mismatch in spatial resolution between the two systems hinders the use of the hybrid system. As the magnetic field of the MRI increased up to 7.0 tesla in the commercial system, the performance of the MRI system largely improved. Several technical attempts in terms of the detector and the software used with the PET were made to improve the performance. As a result, the high resolution of the PET–MRI fusion system enables quantitation of metabolism and molecular information in the small substructures of the brainstem, hippocampus, and thalamus. Many studies on psychiatric disorders, which are difficult to diagnose with medical imaging, have been accomplished using various radioligands, but only a few studies have been conducted using the PET–MRI fusion system. To increase the clinical usefulness of medical imaging in psychiatric disorders, a high-resolution PET–MRI fusion system can play a key role by providing important information on both molecular and structural aspects in the fine structures of the brain. The development of high-resolution PET–MR systems and their potential roles in clinical studies of psychiatric disorders were reviewed as prospective views in future diagnostics.
Author Cho, Zang-Hee
Kim, Jeong-Hee
Kwon, Dae-Hyuk
Kim, Young-Bo
Kim, Jong-Hoon
Son, Young-Don
Lee, Haigun
AuthorAffiliation 5 Biomedical Engineering Research Center, Gachon University, Incheon 21936, Korea; jhkim1104@gachon.ac.kr
3 Department of Neurosurgery, Gachon University College of Medicine, Gil Medical Center, Gachon University, Incheon 21565, Korea
1 Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon 21936, Korea; ydson@gachon.ac.kr
2 Neuroscience Research Institute, Gachon University, Incheon 21565, Korea; neurokim@gachon.ac.kr (Y.-B.K.); jhnp@chol.com (J.-H.K.)
7 Department of Materials Science and Engineering, Institute of Green Manufacturing Technology, Korea University, Seoul 02841, Korea
6 Neuroscience Convergence Center, Institute of Green Manufacturing Technology, Korea University, Seoul 02841, Korea; davidkwon2501@gmail.com
4 Department of Psychiatry, Gachon University College of Medicine, Gil Medical Center, Gachon University, Incheon 21565, Korea
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35631409$$D View this record in MEDLINE/PubMed
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Issue 5
Keywords magnetic resonance imaging
hybrid imaging
positron emission tomography
high resolution
psychiatric disorders
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Snippet A positron emission tomography (PET)-magnetic resonance imaging (MRI) hybrid system has been developed to improve the accuracy of molecular imaging with...
A positron emission tomography (PET)–magnetic resonance imaging (MRI) hybrid system has been developed to improve the accuracy of molecular imaging with...
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SubjectTerms Brain research
Design
FDA approval
high resolution
hybrid imaging
Magnetic fields
Magnetic resonance imaging
Mental disorders
Physical properties
positron emission tomography
psychiatric disorders
Review
Sensors
Tomography
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Title Future Prospects of Positron Emission Tomography-Magnetic Resonance Imaging Hybrid Systems and Applications in Psychiatric Disorders
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