A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis

• Published in: The Journal of clinical investigation Vol. 108; no. 4; pp. 527 - 536
• Main Authors: Haase, I, Hobbs, R M, Romero, M R, Broad, S, Watt, F M
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 15.08.2001
• Subjects: Animals; Antigens, Differentiation - biosynthesis; Cell Differentiation; Cell Division; Cell Line, Transformed; Cells, Cultured; Enzyme Activation; Epidermis - metabolism; Epidermis - ultrastructure; Genes, Synthetic; Humans; Hyperplasia; Integrin beta1 - biosynthesis; Integrin beta1 - genetics; Integrin beta1 - physiology; Integrins - genetics; Integrins - physiology; Interleukin-1 - biosynthesis; Interleukin-1 - genetics; Interleukin-1 - pharmacology; Keratinocytes - enzymology; Keratinocytes - metabolism; MAP Kinase Signaling System; Mice; Mice, Transgenic; Microscopy; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases - genetics; Mitogen-Activated Protein Kinase Kinases - physiology; Mitogen-Activated Protein Kinases - metabolism; Phenotype; Promoter Regions, Genetic; Protein Precursors - genetics; Psoriasis - etiology; Psoriasis - metabolism; Psoriasis - pathology; Receptors, Collagen; Recombinant Fusion Proteins - physiology; Transfection; Wound Healing - genetics

In normal epidermis, beta1 integrin expression is confined to the basal layer, whereas in hyperproliferative epidermis, integrins are also expressed in the suprabasal layers. Transgenic mice in which integrins are expressed suprabasally via the involucrin promoter have a sporadic psoriatic phenotype...