Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis

The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein‐induced acute pancreatitis. For the induction of experimental acute pancreatitis, four subcutaneous injections of caerulein (20 µg kg–1 body weight) were given to Wistar rats at 2‐h intervals. Mel...

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Published inCell biochemistry and function Vol. 31; no. 7; pp. 585 - 590
Main Authors Carrasco, Cristina, Marchena, Ana M., Holguín-Arévalo, María S., Martín-Partido, Gervasio, Rodríguez, Ana B., Paredes, Sergio D., Pariente, José A.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.10.2013
Wiley Subscription Services, Inc
Subjects
Acute Disease
acute pancreatitis
Amylases - blood
Animals
Anti-Inflammatory Agents - therapeutic use
Antioxidants - metabolism
caerulein
Ceruletide
Cytokines - blood
Female
inflammatory effects
interleukins
Lipase - blood
Male
melatonin
Melatonin - therapeutic use
Pancreatitis - chemically induced
Pancreatitis - drug therapy
Pancreatitis - pathology
Rats
Rats, Wistar
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Abstract The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein‐induced acute pancreatitis. For the induction of experimental acute pancreatitis, four subcutaneous injections of caerulein (20 µg kg–1 body weight) were given to Wistar rats at 2‐h intervals. Melatonin was injected intraperitoneally (25 mg kg–1 body weight) 30 min before each caerulein injection. After 12 h, rats were sacrificed by decapitation. Blood and pancreas samples were collected and processed for serological and histopathological studies, respectively. Lipase, α‐amylase, corticosterone, total antioxidant power and cytokines interleukin (IL)‐1β, IL‐4 and tumour necrosis factor (TNF)‐α were determined using commercial kits. ANOVA and Tukey tests (P < 0.05) were performed for the statistical analysis of the results. Results showed that the administration of melatonin reduced histological damage induced by caerulein treatment as well as the hyperamylasemia and hyperlipidemia. Corticosterone and antioxidant total power were also reverted to basal activities. Furthermore, melatonin pre‐treatment reduced pro‐inflammatory cytokines IL‐1β and TNF‐α and increased the serum levels of anti‐inflammatory cytokine IL‐4. In conclusion, the findings suggest that the protective effect of melatonin in caerulein‐induced acute pancreatitis is mediated by the anti‐inflammatory ability of this indolamine. Thus, melatonin may have a protective effect against acute pancreatitis. Copyright © 2013 John Wiley & Sons, Ltd.
AbstractList The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein-induced acute pancreatitis. For the induction of experimental acute pancreatitis, four subcutaneous injections of caerulein (20µgkg-1 body weight) were given to Wistar rats at 2-h intervals. Melatonin was injected intraperitoneally (25mgkg-1 body weight) 30min before each caerulein injection. After 12h, rats were sacrificed by decapitation. Blood and pancreas samples were collected and processed for serological and histopathological studies, respectively. Lipase, [alpha]-amylase, corticosterone, total antioxidant power and cytokines interleukin (IL)-1[beta], IL-4 and tumour necrosis factor (TNF)-[alpha] were determined using commercial kits. ANOVA and Tukey tests (P<0.05) were performed for the statistical analysis of the results. Results showed that the administration of melatonin reduced histological damage induced by caerulein treatment as well as the hyperamylasemia and hyperlipidemia. Corticosterone and antioxidant total power were also reverted to basal activities. Furthermore, melatonin pre-treatment reduced pro-inflammatory cytokines IL-1[beta] and TNF-[alpha] and increased the serum levels of anti-inflammatory cytokine IL-4. In conclusion, the findings suggest that the protective effect of melatonin in caerulein-induced acute pancreatitis is mediated by the anti-inflammatory ability of this indolamine. Thus, melatonin may have a protective effect against acute pancreatitis. Copyright © 2013 John Wiley & Sons, Ltd. [PUBLICATION ABSTRACT]
The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein-induced acute pancreatitis. For the induction of experimental acute pancreatitis, four subcutaneous injections of caerulein (20 mgkg–1 body weight) were given to Wistar rats at 2-h intervals. Melatonin was injected intraperitoneally (25 mg kg–1 body weight) 30 min before each caerulein injection. After 12 h, rats were sacrificed by decapitation. Blood and pancreas samples were collected and processed for serological and histopathological studies,respectively. Lipase, a-amylase, corticosterone, total antioxidant power and cytokines interleukin (IL)-1b, IL-4 and tumour necrosis factor(TNF)-a were determined using commercial kits. ANOVA and Tukey tests (P<0.05) were performed for the statistical analysis of the results.Results showed that the administration of melatonin reduced histological damage induced by caerulein treatment as well as the hyperamylasemia and hyperlipidemia. Corticosterone and antioxidant total power were also reverted to basal activities. Furthermore, melatonin pre-treatment reduced pro-inflammatory cytokines IL-1b and TNF-a and increased the serum levels of anti-inflammatory cytokine IL-4. In conclusion,the findings suggest that the protective effect of melatonin in caerulein-induced acute pancreatitis is mediated by the anti-inflammatory ability of this indolamine. Thus, melatonin may have a protective effect against acute pancreatitis.
The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein‐induced acute pancreatitis. For the induction of experimental acute pancreatitis, four subcutaneous injections of caerulein (20 µg kg–1 body weight) were given to Wistar rats at 2‐h intervals. Melatonin was injected intraperitoneally (25 mg kg–1 body weight) 30 min before each caerulein injection. After 12 h, rats were sacrificed by decapitation. Blood and pancreas samples were collected and processed for serological and histopathological studies, respectively. Lipase, α‐amylase, corticosterone, total antioxidant power and cytokines interleukin (IL)‐1β, IL‐4 and tumour necrosis factor (TNF)‐α were determined using commercial kits. ANOVA and Tukey tests (P < 0.05) were performed for the statistical analysis of the results. Results showed that the administration of melatonin reduced histological damage induced by caerulein treatment as well as the hyperamylasemia and hyperlipidemia. Corticosterone and antioxidant total power were also reverted to basal activities. Furthermore, melatonin pre‐treatment reduced pro‐inflammatory cytokines IL‐1β and TNF‐α and increased the serum levels of anti‐inflammatory cytokine IL‐4. In conclusion, the findings suggest that the protective effect of melatonin in caerulein‐induced acute pancreatitis is mediated by the anti‐inflammatory ability of this indolamine. Thus, melatonin may have a protective effect against acute pancreatitis. Copyright © 2013 John Wiley & Sons, Ltd.
The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein‐induced acute pancreatitis. For the induction of experimental acute pancreatitis, four subcutaneous injections of caerulein (20 µg kg –1 body weight) were given to Wistar rats at 2‐h intervals. Melatonin was injected intraperitoneally (25 mg kg –1 body weight) 30 min before each caerulein injection. After 12 h, rats were sacrificed by decapitation. Blood and pancreas samples were collected and processed for serological and histopathological studies, respectively. Lipase, α‐amylase, corticosterone, total antioxidant power and cytokines interleukin (IL)‐1β, IL‐4 and tumour necrosis factor (TNF)‐α were determined using commercial kits. ANOVA and Tukey tests ( P  < 0.05) were performed for the statistical analysis of the results. Results showed that the administration of melatonin reduced histological damage induced by caerulein treatment as well as the hyperamylasemia and hyperlipidemia. Corticosterone and antioxidant total power were also reverted to basal activities. Furthermore, melatonin pre‐treatment reduced pro‐inflammatory cytokines IL‐1β and TNF‐α and increased the serum levels of anti‐inflammatory cytokine IL‐4. In conclusion, the findings suggest that the protective effect of melatonin in caerulein‐induced acute pancreatitis is mediated by the anti‐inflammatory ability of this indolamine. Thus, melatonin may have a protective effect against acute pancreatitis. Copyright © 2013 John Wiley & Sons, Ltd.
The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein-induced acute pancreatitis. For the induction of experimental acute pancreatitis, four subcutaneous injections of caerulein (20 mgkg–1 body weight) were given to Wistar rats at 2-h intervals. Melatonin was injected intraperitoneally (25 mg kg–1 body weight) 30 min before each caerulein injection. After 12 h, rats were sacrificed by decapitation. Blood and pancreas samples were collected and processed for serological and histopathological studies,respectively. Lipase, a-amylase, corticosterone, total antioxidant power and cytokines interleukin (IL)-1b, IL-4 and tumour necrosis factor(TNF)-a were determined using commercial kits. ANOVA and Tukey tests (P&lt;0.05) were performed for the statistical analysis of the results.Results showed that the administration of melatonin reduced histological damage induced by caerulein treatment as well as the hyperamylasemia and hyperlipidemia. Corticosterone and antioxidant total power were also reverted to basal activities. Furthermore, melatonin pre-treatment reduced pro-inflammatory cytokines IL-1b and TNF-a and increased the serum levels of anti-inflammatory cytokine IL-4. In conclusion,the findings suggest that the protective effect of melatonin in caerulein-induced acute pancreatitis is mediated by the anti-inflammatory ability of this indolamine. Thus, melatonin may have a protective effect against acute pancreatitis.
Author Carrasco, Cristina
Marchena, Ana M.
Holguín-Arévalo, María S.
Rodríguez, Ana B.
Paredes, Sergio D.
Martín-Partido, Gervasio
Pariente, José A.
Author_xml – sequence: 1
  givenname: Cristina
  surname: Carrasco
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– sequence: 2
  givenname: Ana M.
  surname: Marchena
  fullname: Marchena, Ana M.
  organization: Department of Physiology, Neuroimmunophysiology and Chrononutrition Research Group, University of Extremadura, Badajoz, Spain
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  givenname: María S.
  surname: Holguín-Arévalo
  fullname: Holguín-Arévalo, María S.
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  givenname: Gervasio
  surname: Martín-Partido
  fullname: Martín-Partido, Gervasio
  organization: Department of Cellular Biology, University of Extremadura, Badajoz, Spain
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  givenname: Ana B.
  surname: Rodríguez
  fullname: Rodríguez, Ana B.
  organization: Department of Physiology, Neuroimmunophysiology and Chrononutrition Research Group, University of Extremadura, Badajoz, Spain
– sequence: 6
  givenname: Sergio D.
  surname: Paredes
  fullname: Paredes, Sergio D.
  organization: Department of Physiology, Complutense University of Madrid, Madrid, Spain
– sequence: 7
  givenname: José A.
  surname: Pariente
  fullname: Pariente, José A.
  email: Correspondence to: José A. Pariente, Neuroimmunophysiology and Chrononutrition Research Group. Department of Physiology, Faculty of Science. University of Extremadura, 06071, Badajoz, Spain., pariente@unex.es
  organization: Department of Physiology, Neuroimmunophysiology and Chrononutrition Research Group, University of Extremadura, Badajoz, Spain
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2010; 628
1993; 128
2012; 2012
2000; 6
2006; 12
2002; 53
1984; 200
2002; 1588
1999; 27
1986; 151
1999; 45
2008; 56
1999; 44
2000; 93
2000; 231
2000; 232
1992; 33
1994; 41
2012; 10
2012; 53
1998; 175
1992; 51
2012; 52
2003; 34
1998; 24
2004; 55
2002; 47
1995; 82
2010; 48
2009; 10
1988; 29
2004; 37
2011; 51
2003; 9
1982; 22
1992; 215
2005; 32
1999; 377
1995; 268
1999; 31
1958; 80
1979; 382
1996; 20
2010; 9
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Snippet The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein‐induced acute pancreatitis. For the induction of...
The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein-induced acute pancreatitis. For the induction of...
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SubjectTerms Acute Disease
acute pancreatitis
Amylases - blood
Animals
Anti-Inflammatory Agents - therapeutic use
Antioxidants - metabolism
caerulein
Ceruletide
Cytokines - blood
Female
inflammatory effects
interleukins
Lipase - blood
Male
melatonin
Melatonin - therapeutic use
Pancreatitis - chemically induced
Pancreatitis - drug therapy
Pancreatitis - pathology
Rats
Rats, Wistar
Title Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis
URI https://api.istex.fr/ark:/67375/WNG-RFMFTLNN-T/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcbf.2942
https://www.ncbi.nlm.nih.gov/pubmed/24779037
https://www.proquest.com/docview/1465267664
https://search.proquest.com/docview/1520108486
Volume 31
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