Ferroptosis Related Immunomodulatory Effect of a Novel Extracellular Polysaccharides from Marine Fungus Aureobasidium melanogenum

Marine fungi represent an important and sustainable resource, from which the search for novel biological substances for application in the pharmacy or food industry offers great potential. In our research, novel polysaccharide (AUM-1) was obtained from marine SCAU-266 were obtained and the molecular...

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Published inMarine drugs Vol. 20; no. 5; p. 332
Main Authors Lin, Yuqi, Yang, Jiajia, Luo, Lianxiang, Zhang, Xiaoyong, Deng, Shengyu, Chen, Xiaodan, Li, Yiyang, Bekhit, Alaa El-Din A, Xu, Baojun, Huang, Riming
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 19.05.2022
MDPI
Subjects
Aureobasidium melanogenum
Cyclooxygenase-2
Cytokines
Extracellular
Ferroptosis
Food industry
Fungi
Galactose
Glucose
Glutathione
Immunomodulation
immunomodulatory
Lipid peroxidation
Lipids
Mannose
Metabolism
Metabolites
Molecular weight
Peroxidation
polysaccharide
Polysaccharides
Saccharides
Scientific imaging
structural characterization
Sulfur trioxide
Tricarboxylic acid cycle
Vibration
Aureobasidium melanogenum
ferroptosis
polysaccharide
structural characterization
immunomodulatory
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Abstract Marine fungi represent an important and sustainable resource, from which the search for novel biological substances for application in the pharmacy or food industry offers great potential. In our research, novel polysaccharide (AUM-1) was obtained from marine SCAU-266 were obtained and the molecular weight of AUM-1 was determined to be 8000 Da with 97.30% of glucose, 1.9% of mannose, and 0.08% galactose, owing to a potential backbone of α-D-Glcp-(1→2)-α-D-Manp-(1→4)-α-D-Glcp-(1→6)-(SO )-4-α-D-Glcp-(1→6)-1-β-D-Glcp-1→2)-α-D-Glcp-(1→6)-β-D-Glcp-1→6)-α-D-Glcp-1→4)-α-D-Glcp-6→1)-[α-D-Glcp-4] →1)-α-D-Glcp and two side chains that consisted of α-D-Glcp-1 and α-D-Glcp-(1→6)-α-D-Glcp residues. The immunomodulatory effect of AUM-1 was identified. Then, the potential molecular mechanism by which AUM-1 may be connected to ferroptosis was indicated by metabonomics, and the expression of COX2, SLC7A11, GPX4, ACSL4, FTH1, and ROS were further verified. Thus, we first speculated that AUM-1 has a potential effect on the ferroptosis-related immunomodulatory property in RAW 264.7 cells by adjusting the expression of GPX4, regulated glutathione (oxidative), directly causing lipid peroxidation owing to the higher ROS level through the glutamate metabolism and TCA cycle. Thus, the ferroptosis related immunomodulatory effect of AUM-1 was obtained.
AbstractList Marine fungi represent an important and sustainable resource, from which the search for novel biological substances for application in the pharmacy or food industry offers great potential. In our research, novel polysaccharide (AUM-1) was obtained from marine SCAU-266 were obtained and the molecular weight of AUM-1 was determined to be 8000 Da with 97.30% of glucose, 1.9% of mannose, and 0.08% galactose, owing to a potential backbone of α-D-Glcp-(1→2)-α-D-Manp-(1→4)-α-D-Glcp-(1→6)-(SO )-4-α-D-Glcp-(1→6)-1-β-D-Glcp-1→2)-α-D-Glcp-(1→6)-β-D-Glcp-1→6)-α-D-Glcp-1→4)-α-D-Glcp-6→1)-[α-D-Glcp-4] →1)-α-D-Glcp and two side chains that consisted of α-D-Glcp-1 and α-D-Glcp-(1→6)-α-D-Glcp residues. The immunomodulatory effect of AUM-1 was identified. Then, the potential molecular mechanism by which AUM-1 may be connected to ferroptosis was indicated by metabonomics, and the expression of COX2, SLC7A11, GPX4, ACSL4, FTH1, and ROS were further verified. Thus, we first speculated that AUM-1 has a potential effect on the ferroptosis-related immunomodulatory property in RAW 264.7 cells by adjusting the expression of GPX4, regulated glutathione (oxidative), directly causing lipid peroxidation owing to the higher ROS level through the glutamate metabolism and TCA cycle. Thus, the ferroptosis related immunomodulatory effect of AUM-1 was obtained.
Marine fungi represent an important and sustainable resource, from which the search for novel biological substances for application in the pharmacy or food industry offers great potential. In our research, novel polysaccharide (AUM-1) was obtained from marine Aureobasidium melanogenum SCAU-266 were obtained and the molecular weight of AUM-1 was determined to be 8000 Da with 97.30% of glucose, 1.9% of mannose, and 0.08% galactose, owing to a potential backbone of α-D-Glcp-(1→2)-α-D-Manp-(1→4)-α-D-Glcp-(1→6)-(SO3−)-4-α-D-Glcp-(1→6)-1-β-D-Glcp-1→2)-α-D-Glcp-(1→6)-β-D-Glcp-1→6)-α-D-Glcp-1→4)-α-D-Glcp-6→1)-[α-D-Glcp-4]26→1)-α-D-Glcp and two side chains that consisted of α-D-Glcp-1 and α-D-Glcp-(1→6)-α-D-Glcp residues. The immunomodulatory effect of AUM-1 was identified. Then, the potential molecular mechanism by which AUM-1 may be connected to ferroptosis was indicated by metabonomics, and the expression of COX2, SLC7A11, GPX4, ACSL4, FTH1, and ROS were further verified. Thus, we first speculated that AUM-1 has a potential effect on the ferroptosis-related immunomodulatory property in RAW 264.7 cells by adjusting the expression of GPX4, regulated glutathione (oxidative), directly causing lipid peroxidation owing to the higher ROS level through the glutamate metabolism and TCA cycle. Thus, the ferroptosis related immunomodulatory effect of AUM-1 was obtained.
Marine fungi represent an important and sustainable resource, from which the search for novel biological substances for application in the pharmacy or food industry offers great potential. In our research, novel polysaccharide (AUM-1) was obtained from marine Aureobasidium melanogenum SCAU-266 were obtained and the molecular weight of AUM-1 was determined to be 8000 Da with 97.30% of glucose, 1.9% of mannose, and 0.08% galactose, owing to a potential backbone of α-D-Glcp-(1→2)-α-D-Manp-(1→4)-α-D-Glcp-(1→6)-(SO 3 − )-4-α-D-Glcp-(1→6)-1-β-D-Glcp-1→2)-α-D-Glcp-(1→6)-β-D-Glcp-1→6)-α-D-Glcp-1→4)-α-D-Glcp-6→1)-[α-D-Glcp-4] 26 →1)-α-D-Glcp and two side chains that consisted of α-D-Glcp-1 and α-D-Glcp-(1→6)-α-D-Glcp residues. The immunomodulatory effect of AUM-1 was identified. Then, the potential molecular mechanism by which AUM-1 may be connected to ferroptosis was indicated by metabonomics, and the expression of COX2, SLC7A11, GPX4, ACSL4, FTH1, and ROS were further verified. Thus, we first speculated that AUM-1 has a potential effect on the ferroptosis-related immunomodulatory property in RAW 264.7 cells by adjusting the expression of GPX4, regulated glutathione (oxidative), directly causing lipid peroxidation owing to the higher ROS level through the glutamate metabolism and TCA cycle. Thus, the ferroptosis related immunomodulatory effect of AUM-1 was obtained.
Author Huang, Riming
Luo, Lianxiang
Chen, Xiaodan
Lin, Yuqi
Zhang, Xiaoyong
Deng, Shengyu
Bekhit, Alaa El-Din A
Li, Yiyang
Yang, Jiajia
Xu, Baojun
AuthorAffiliation 3 The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China
1 Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China; linyuqi@stu.scau.edu.cn (Y.L.); yangjiajia@stu.scau.edu.cn (J.Y.); dengsy202013@163.com (S.D.); 18125907913@163.com (X.C.)
4 Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; zhangxiaoyong@scau.edu.cn (X.Z.); li-yiyang0731@126.com (Y.L.)
6 Food Science and Technology Program, Beijing Normal University−Hong Kong Baptist University−United International College, Zhuhai 519087, China; baojunxu@uic.edu.cn
2 The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China; luolianxiang321@gdmu.edu.cn
5 Department of Food Sciences, University of Otago, P.O. Box 56, Dunedin 9054
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– name: 6 Food Science and Technology Program, Beijing Normal University−Hong Kong Baptist University−United International College, Zhuhai 519087, China; baojunxu@uic.edu.cn
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Issue 5
Keywords Aureobasidium melanogenum
ferroptosis
polysaccharide
structural characterization
immunomodulatory
Language English
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Snippet Marine fungi represent an important and sustainable resource, from which the search for novel biological substances for application in the pharmacy or food...
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SubjectTerms Aureobasidium melanogenum
Cyclooxygenase-2
Cytokines
Extracellular
Ferroptosis
Food industry
Fungi
Galactose
Glucose
Glutathione
Immunomodulation
immunomodulatory
Lipid peroxidation
Lipids
Mannose
Metabolism
Metabolites
Molecular weight
Peroxidation
polysaccharide
Polysaccharides
Saccharides
Scientific imaging
structural characterization
Sulfur trioxide
Tricarboxylic acid cycle
Vibration
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Title Ferroptosis Related Immunomodulatory Effect of a Novel Extracellular Polysaccharides from Marine Fungus Aureobasidium melanogenum
URI https://www.ncbi.nlm.nih.gov/pubmed/35621983
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https://pubmed.ncbi.nlm.nih.gov/PMC9144548
https://doaj.org/article/5ab5b621ef0a4b6fa3c27c194797c512
Volume 20
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