Molecular heterogeneity of non‐small cell lung carcinoma patient‐derived xenografts closely reflect their primary tumors

• Published in: International journal of cancer Vol. 140; no. 3; pp. 662 - 673
• Main Authors: Wang, Dennis, Pham, Nhu‐An, Tong, Jiefei, Sakashita, Shingo, Allo, Ghassan, Kim, Lucia, Yanagawa, Naoki, Raghavan, Vibha, Wei, Yuhong, To, Christine, Trinh, Quang M., Starmans, Maud H.W., Chan‐Seng‐Yue, Michelle A., Chadwick, Dianne, Li, Lei, Zhu, Chang‐Qi, Liu, Ni, Li, Ming, Lee, Sharon, Ignatchenko, Vladimir, Strumpf, Dan, Taylor, Paul, Moghal, Nadeem, Liu, Geoffrey, Boutros, Paul C., Kislinger, Thomas, Pintilie, Melania, Jurisica, Igor, Shepherd, Frances A., McPherson, John D., Muthuswamy, Lakshmi, Moran, Michael F., Tsao, Ming‐Sound
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2017
• Subjects: Adult; Aged; Animals; Cancer; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell Line, Tumor; copy number aberration; Disease Models, Animal; DNA methylation; Female; Heterografts - pathology; Humans; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; mass spectrometry; Medical research; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Mutation; Mutation - genetics; non‐small cell lung cancer; Patients; phosphotyrosine‐proteomics; Polymorphism, Single Nucleotide - genetics; Rodents; transcriptome; Tumors; whole exome next generation sequencing; xenograft; Xenograft Model Antitumor Assays - methods; non-small cell lung cancer; xenograft; transcriptome; DNA methylation; mass spectrometry; phosphotyrosine-proteomics; copy number aberration; whole exome next generation sequencing

Availability of lung cancer models that closely mimic human tumors remains a significant gap in cancer research, as tumor cell lines and mouse models may not recapitulate the spectrum of lung cancer heterogeneity seen in patients. We aimed to establish a patient‐derived tumor xenograft (PDX) resourc...