Immune mechanisms in heart failure

• Published in: European journal of heart failure Vol. 19; no. 11; pp. 1379 - 1389
• Main Authors: Zhang, Yingying, Bauersachs, Johann, Langer, Harald F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK John Wiley & Sons, Ltd 01.11.2017
• Subjects: Animals; Antigen presenting cells; Biomarkers - metabolism; Disease Progression; Heart failure; Heart Failure - immunology; Heart Failure - metabolism; Heart Failure - physiopathology; Humans; Immune response; Immunity, Innate; Inflammation; Inflammation - immunology; Inflammation - metabolism; Stroke Volume - physiology; Heart failure; Antigen presenting cells; Inflammation; Immune response

Elevated levels of circulating pro‐inflammatory biomarkers in patients with both ischaemic and non‐ischaemic heart failure (HF) correlate with disease severity and prognosis. Experimental studies have shown activation of immune response mechanisms in the heart to provoke cardiac adverse remodelling...