Dental properties, ultrastructure, and pulp cells associated with a novel DSPP mutation

• Published in: Oral diseases Vol. 24; no. 4; pp. 619 - 627
• Main Authors: Porntaveetus, T, Osathanon, T, Nowwarote, N, Pavasant, P, Srichomthong, C, Suphapeetiporn, K, Shotelersuk, V
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.05.2018; Wiley
• Subjects: Base Sequence; CD105 antigen; Cell Differentiation; Cell growth; Cell Proliferation; Cells, Cultured; Child, Preschool; Clonal deletion; Colonies; Colony-Forming Units Assay; Dental enamel; Dental Pulp; dental pulp cells; Dentin; dentin sialophosphoprotein; dentinal tubules; Dentinogenesis; Dentinogenesis Imperfecta; Dspp protein; Endoglin; exome sequencing; Extracellular Matrix Proteins; Gene deletion; Humans; Life Sciences; Male; Mesenchyme; Mutation; Pedigree; Phenotype; Phosphoproteins; Physical characteristics; Pluripotency; Sequence Deletion; Sialoglycoproteins; Stem cells; Teeth; Tubules; Ultrastructure; dentinogenesis imperfecta; dentin sialophosphoprotein; dental pulp cells; exome sequencing; dentinal tubules

Objective To investigate physical characteristics and behaviours of dental pulp cells of teeth isolated from a dentinogenesis imperfecta (DGI) patient with a novel dentin sialophosphoprotein (DSPP) mutation. Subjects and Methods Whole exome and Sanger sequencing were employed to identify mutations....