Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity - Puumala, Emily; Sychantha, David; Lach, Elizabeth; Reeves, Shawn; Nabeela, Sunna; Fogal, Meea; Nigam, AkshatKumar; Johnson, Jarrod W.; Aspuru-Guzik, Alán; Shapiro, Rebecca S.; Uppuluri, Priya; Kalyaanamoorthy, Subha; et al. (Cell chemical biology, 2024)
Keywords: Amino Acyl-tRNA Synthetases - genetics; Animals; antifungal; Antifungal Agents - pharmacology; Candida; Candida albicans; fungal pathogens; Gln4; glutaminyl-tRNA synthetase; Mice; Structure-Activity Relationship; translation inhibitor; antifungal; Gln4; glutaminyl-tRNA synthetase; translation inhibitor; fungal pathogens; Candida