Dietary l -tryptophan alleviated LPS-induced intestinal barrier injury by regulating tight junctions in a Caco-2 cell monolayer model

• Published in: Food & function Vol. 10; no. 5; pp. 2390 - 2398
• Main Authors: Chen, Mengdie, Liu, Yuyu, Xiong, Shanbai, Wu, Moucheng, Li, Bin, Ruan, Zheng, Hu, Xiaobo
• Format: Journal Article
• Language: English
• Published: England 22.05.2019
• Subjects: epithelium; gene expression; gene expression regulation; human cell lines; inflammation; intestines; lipopolysaccharides; messenger RNA; myosin; occludins; permeability; protein kinases; protein synthesis; signal transduction; tight junctions; transcription factor NF-kappa B; tryptophan

The intestinal epithelial layer forms a barrier through cell–cell tight junctions and breaking or even slightly disrupting this barrier can lead to serious pathological consequences, including infection and inflammation. Various amino acids have been shown to improve the intestinal tract, but the ef...