Intracellular Calcium Signalling and Vascular Reactivity in Bartter’s Syndrome

• Published in: Nephron Vol. 72; no. 4; pp. 570 - 573
• Main Authors: Calò, Lorenzo, D’Angelo, Angela, Cantaro, Salvatore, Rizzolo, Monica, Favaro, Silvana, Antonello, Augusto, Borsatti, Arturo
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 1996
• Subjects: Adult; Affinity; Bartter Syndrome - physiopathology; Blood Vessels - physiopathology; Calcium (intracellular); Calcium - physiology; Calcium signalling; Female; Formyl peptides; Humans; Inosine Triphosphate - biosynthesis; Inositol 1,4,5-trisphosphate receptors; Intracellular; Intracellular signalling; Kinetics; Leukocytes (neutrophilic); Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine - pharmacology; Neutrophils; Neutrophils - metabolism; Original Paper; Phenylalanine; Receptors, Formyl Peptide; Receptors, Immunologic - metabolism; Receptors, Peptide - metabolism; Signal Transduction - physiology; Calcium signalling; Bartter's syndrome; Vascular reactivity; IP3

We investigated patients affected by Bartter’s syndrome in the attempt to localize the intracellular defect mediating the reduced intracellular Ca 2+ mobilization that may be responsible for the decreased vascular reactivity characteristic of Bartter’s syndrome. Using the formylmethionyl-leucyl-phen...