The Emerging Role of Combined Brain/Heart Magnetic Resonance Imaging for the Evaluation of Brain/Heart Interaction in Heart Failure

Heart failure (HF) patients frequently develop brain deficits that lead to cognitive dysfunction (CD), which may ultimately also affect survival. There is an important interaction between brain and heart that becomes crucial for survival in patients with HF. Our aim was to review the brain/heart int...

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Published inJournal of clinical medicine Vol. 11; no. 14; p. 4009
Main Authors Markousis-Mavrogenis, George, Noutsias, Michel, Rigopoulos, Angelos G., Giannakopoulou, Aikaterini, Gatzonis, Stergios, Pons, Roser Maria, Papavasiliou, Antigoni, Vartela, Vasiliki, Bonou, Maria, Kolovou, Genovefa, Aggeli, Constantina, Christidi, Aikaterini, Bacopoulou, Flora, Tousoulis, Dimitris, Mavrogeni, Sophie
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 11.07.2022
MDPI
Subjects
Alzheimer's disease
Cardiovascular disease
Clinical medicine
Cognition & reasoning
Cognitive ability
Ejection fraction
Flow velocity
Heart failure
Hormones
Magnetic resonance imaging
Mortality
Review
Risk factors
Stroke
Transplants & implants
Traumatic brain injury
Vitamin B
Vitamin deficiency
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Abstract Heart failure (HF) patients frequently develop brain deficits that lead to cognitive dysfunction (CD), which may ultimately also affect survival. There is an important interaction between brain and heart that becomes crucial for survival in patients with HF. Our aim was to review the brain/heart interactions in HF and discuss the emerging role of combined brain/heart magnetic resonance imaging (MRI) evaluation. A scoping review of published literature was conducted in the PubMed EMBASE (OVID), Web of Science, Scopus and PsycInfo databases. Keywords for searches included heart failure, brain lesion, brain, cognitive, cognitive dysfunction, magnetic resonance imaging cardiovascular magnetic resonance imaging electroencephalogram, positron emission tomography and echocardiography. CD testing, the most commonly used diagnostic approach, can identify neither subclinical cases nor the pathophysiologic background of CD. A combined brain/heart MRI has the capability of diagnosing brain/heart lesions at an early stage and potentially facilitates treatment. Additionally, valuable information about edema, fibrosis and cardiac remodeling, provided with the use of cardiovascular magnetic resonance, can improve HF risk stratification and treatment modification. However, availability, familiarity with this modality and cost should be taken under consideration before final conclusions can be drawn. Abnormal CD testing in HF patients is a strong motivating factor for applying a combined brain/heart MRI to identify early brain/heart lesions and modify risk stratification accordingly.
AbstractList Heart failure (HF) patients frequently develop brain deficits that lead to cognitive dysfunction (CD), which may ultimately also affect survival. There is an important interaction between brain and heart that becomes crucial for survival in patients with HF. Our aim was to review the brain/heart interactions in HF and discuss the emerging role of combined brain/heart magnetic resonance imaging (MRI) evaluation. A scoping review of published literature was conducted in the PubMed EMBASE (OVID), Web of Science, Scopus and PsycInfo databases. Keywords for searches included heart failure, brain lesion, brain, cognitive, cognitive dysfunction, magnetic resonance imaging cardiovascular magnetic resonance imaging electroencephalogram, positron emission tomography and echocardiography. CD testing, the most commonly used diagnostic approach, can identify neither subclinical cases nor the pathophysiologic background of CD. A combined brain/heart MRI has the capability of diagnosing brain/heart lesions at an early stage and potentially facilitates treatment. Additionally, valuable information about edema, fibrosis and cardiac remodeling, provided with the use of cardiovascular magnetic resonance, can improve HF risk stratification and treatment modification. However, availability, familiarity with this modality and cost should be taken under consideration before final conclusions can be drawn. Abnormal CD testing in HF patients is a strong motivating factor for applying a combined brain/heart MRI to identify early brain/heart lesions and modify risk stratification accordingly.
Author Giannakopoulou, Aikaterini
Bacopoulou, Flora
Vartela, Vasiliki
Tousoulis, Dimitris
Bonou, Maria
Mavrogeni, Sophie
Rigopoulos, Angelos G.
Gatzonis, Stergios
Christidi, Aikaterini
Pons, Roser Maria
Papavasiliou, Antigoni
Noutsias, Michel
Aggeli, Constantina
Kolovou, Genovefa
Markousis-Mavrogenis, George
AuthorAffiliation 1 Onassis Cardiac Surgery Center, 17674 Athens, Greece; georgemm32@gmail.com (G.M.-M.); vasvartela@yahoo.gr (V.V.); genovefa@kolovou.com (G.K.)
5 Aghia Sophia Children’s Hospital, 11527 Athens, Greece; aikaterinigiannakopoulou@hotmail.com (A.G.); roserpons@med.uoa.gr (R.M.P.); fbacopoulou@med.uoa.gr (F.B.)
6 Evangelismos Hospital, 10676 Athens, Greece
9 Laikon Hospital, 11527 Athens, Greece; bonou.maria@yahoo.com
3 Medical Faculty, Martin Luther-University Halle-Wittenberg, Magdeburger Strasse 8, D-06112 Halle (Saale), Germany
10 First Cardiac Clinic, Hippokration Hospital, 11527 Athens, Greece
7 Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece; dina.aggeli@gmail.com (C.A.); dtousoulis@hotmail.com (D.T.)
8 Iaso Children’s Hospital, 15123 Athens, Greece; theon@otenet.gr
12 Clinic for Assessment of Adolescent Learning Difficulties, Center for Adolescent Medicine and UNESCO Chair in Adolescent Health Care, First Department of Pediatrics, Medical School, Nationa
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CitedBy_id crossref_primary_10_3390_ijms25010263
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Snippet Heart failure (HF) patients frequently develop brain deficits that lead to cognitive dysfunction (CD), which may ultimately also affect survival. There is an...
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proquest
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StartPage 4009
SubjectTerms Alzheimer's disease
Cardiovascular disease
Clinical medicine
Cognition & reasoning
Cognitive ability
Ejection fraction
Flow velocity
Heart failure
Hormones
Magnetic resonance imaging
Mortality
Review
Risk factors
Stroke
Transplants & implants
Traumatic brain injury
Vitamin B
Vitamin deficiency
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Title The Emerging Role of Combined Brain/Heart Magnetic Resonance Imaging for the Evaluation of Brain/Heart Interaction in Heart Failure
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