Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis

• Published in: Journal of the American Society of Nephrology Vol. 26; no. 8; pp. 1855 - 1876
• Main Authors: Saliba, Youakim, Karam, Ralph, Smayra, Viviane, Aftimos, Georges, Abramowitz, Joel, Birnbaumer, Lutz, Farès, Nassim
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.08.2015
• Subjects: Animals; Basic Research; Calcium - metabolism; Cell Differentiation; Cell Proliferation; Cells, Cultured; Extracellular Matrix - metabolism; Fibroblasts - cytology; Fibroblasts - metabolism; Fibrosis; Kidney - pathology; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; Myofibroblasts - cytology; Phenotype; Protein Isoforms - metabolism; Rats, Wistar; Renal Insufficiency, Chronic - etiology; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; TRPC Cation Channels - metabolism; Up-Regulation; Ureteral Obstruction; calcium; fibroblast; signaling; ion channel; kidney disease; cell; renal fibrosis

Transient receptor potential canonical (TRPC) Ca(2+)-permeant channels, especially TRPC3, are increasingly implicated in cardiorenal diseases. We studied the possible role of fibroblast TRPC3 in the development of renal fibrosis. In vitro, a macromolecular complex formed by TRPC1/TRPC3/TRPC6 existed...