Systemic interferon gamma treatment in severe atopic dermatitis
Background: Recent results suggest decreased interferon gamma (IFN-γ) but high interleukin 4 (IL-4) production in patients with atopic dermatitis (AD). Because the relative activities of IL-4 and IFN-γ seem to regulate the amplitude of the IgE response we suggested a role for IFN-γ in the treatment...
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Published in | Journal of the American Academy of Dermatology Vol. 29; no. 1; pp. 58 - 63 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Mosby, Inc
01.07.1993
Elsevier |
Subjects | |
Online Access | Get full text |
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Abstract | Background:
Recent results suggest decreased interferon gamma (IFN-γ) but high interleukin 4 (IL-4) production in patients with atopic dermatitis (AD). Because the relative activities of IL-4 and IFN-γ seem to regulate the amplitude of the IgE response we suggested a role for IFN-γ in the treatment of AD.
Objective:
The purpose of this study was to assess the efficacy of systemic IFN-γ treatment in patients with severe AD.
Methods:
Patients with severe AD (
n = 14) were treated with recombinant IFN-γ for 6 weeks. During the study only basic local therapy with steroid-free hydrophilic or emollient ointments was allowed.
Results:
Eight patients (57%) showed marked clinical improvement during systemic IFN-γ therapy, Four of these patients showed continuous improvement 3 months after treatment was discontinued. Mean total and antigen-specific serum IgE concentrations were not statistically different during and after treatment, whereas mean spontaneous IgE production in vitro was significantly lower after 6 weeks of IFN-γ therapy.
Conclusion:
Our results suggest that IFN-γ treatment may represent a novel therapeutic approach in patients with severe AD. |
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AbstractList | Background:
Recent results suggest decreased interferon gamma (IFN-γ) but high interleukin 4 (IL-4) production in patients with atopic dermatitis (AD). Because the relative activities of IL-4 and IFN-γ seem to regulate the amplitude of the IgE response we suggested a role for IFN-γ in the treatment of AD.
Objective:
The purpose of this study was to assess the efficacy of systemic IFN-γ treatment in patients with severe AD.
Methods:
Patients with severe AD (
n = 14) were treated with recombinant IFN-γ for 6 weeks. During the study only basic local therapy with steroid-free hydrophilic or emollient ointments was allowed.
Results:
Eight patients (57%) showed marked clinical improvement during systemic IFN-γ therapy, Four of these patients showed continuous improvement 3 months after treatment was discontinued. Mean total and antigen-specific serum IgE concentrations were not statistically different during and after treatment, whereas mean spontaneous IgE production in vitro was significantly lower after 6 weeks of IFN-γ therapy.
Conclusion:
Our results suggest that IFN-γ treatment may represent a novel therapeutic approach in patients with severe AD. BACKGROUNDRecent results suggest decreased interferon gamma (IFN-gamma) but high interleukin 4 (IL-4) production in patients with atopic dermatitis (AD). Because the relative activities of IL-4 and IFN-gamma seem to regulate the amplitude of the IgE response we suggested a role for IFN-gamma in the treatment of AD.OBJECTIVEThe purpose of this study was to assess the efficacy of systemic IFN-gamma treatment in patients with severe AD.METHODSPatients with severe AD (n = 14) were treated with recombinant IFN-gamma for 6 weeks. During the study only basic local therapy with steroid-free hydrophilic or emollient ointments was allowed.RESULTSEight patients (57%) showed marked clinical improvement during systemic IFN-gamma therapy. Four of these patients showed continuous improvement 3 months after treatment was discontinued. Mean total and antigen-specific serum IgE concentrations were not statistically different during and after treatment, whereas mean spontaneous IgE production in vitro was significantly lower after 6 weeks of IFN-gamma therapy.CONCLUSIONOur results suggest that IFN-gamma treatment may represent a novel therapeutic approach in patients with severe AD. Recent results suggest decreased interferon gamma (IFN-gamma) but high interleukin 4 (IL-4) production in patients with atopic dermatitis (AD). Because the relative activities of IL-4 and IFN-gamma seem to regulate the amplitude of the IgE response we suggested a role for IFN-gamma in the treatment of AD. The purpose of this study was to assess the efficacy of systemic IFN-gamma treatment in patients with severe AD. Patients with severe AD (n = 14) were treated with recombinant IFN-gamma for 6 weeks. During the study only basic local therapy with steroid-free hydrophilic or emollient ointments was allowed. Eight patients (57%) showed marked clinical improvement during systemic IFN-gamma therapy. Four of these patients showed continuous improvement 3 months after treatment was discontinued. Mean total and antigen-specific serum IgE concentrations were not statistically different during and after treatment, whereas mean spontaneous IgE production in vitro was significantly lower after 6 weeks of IFN-gamma therapy. Our results suggest that IFN-gamma treatment may represent a novel therapeutic approach in patients with severe AD. |
Author | Brzoska, Josef Reinhold, Uwe Kreysel, Hans Wilhelm Kukel, Sylvia |
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Keywords | Human Immunopathology Skin disease Treatment Atopic dermatitis Cytokine Adult Systemic route Gamma interferon |
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References_xml | – volume: 1 start-page: 1282 year: 1990 ident: bib8 article-title: Recombinant IFN-gamma in severe atopic dermatitis publication-title: Lancet contributor: fullname: Kukel – volume: 92 start-page: 44 year: 1980 end-page: 47 ident: bib10 article-title: Diagnostic features of atopic dermatitis publication-title: Acta Derm Venereol (Stockh) contributor: fullname: Rajka – start-page: 379 year: 1990 ident: bib14 article-title: Immunomodulating effects of interferons: conclusions for therapy publication-title: Genital papillomavirus infections contributor: fullname: Obert – volume: 85 start-page: 307 year: 1991 end-page: 311 ident: bib16 article-title: Recombinant interferon-gamma inhibits the expression of IL-4 receptors on human lymphocytes publication-title: Clin Exp Immunol contributor: fullname: Wooton – volume: 79 start-page: 374 year: 1990 end-page: 379 ident: bib5 article-title: Evidence that defective interferon-gamma production in atopic dermatitis patients is due to intrinsic abnormalities publication-title: Clin Exp Immunol contributor: fullname: Kukel – volume: 86 start-page: 444 year: 1991 end-page: 448 ident: bib7 article-title: Functional characterization of skin-infiltrating lymphocytes in atopic dermatitis publication-title: Clin Exp Immunol contributor: fullname: Goeden – volume: 20 start-page: 243 year: 1990 end-page: 251 ident: bib15 article-title: Regulation of human IgE synthesis. 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Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon-gamma publication-title: Eur J Immunol contributor: fullname: Brière – volume: 4 start-page: 67 year: 1986 end-page: 86 ident: bib1 article-title: Immunoregulatory abnormalities in atopic dermatitis publication-title: Clin Rev Allergy contributor: fullname: Geha – volume: 87 start-page: 120 year: 1988 end-page: 126 ident: bib4 article-title: Immunoglobulin E and immunoglobulin G subclass distribution in vivo and relationship to in vitro generation of interferon-gamma and neopterin in patients with severe atopic dermatitis publication-title: Int Arch Allergy Appl Immunol contributor: fullname: Wehrmann – volume: 87 start-page: 58 year: 1991 end-page: 69 ident: bib6 article-title: Shifts in interleukin-4 and interferon-gamma production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis publication-title: J Allergy Clin Immunol contributor: fullname: Andary – volume: 144 start-page: 13 year: 1989 end-page: 14 ident: bib11 article-title: Grading of the severity of atopic dermatitis publication-title: Acta Derm Venereol Suppl (Stockh) contributor: fullname: Langeland – volume: 85 start-page: 934 year: 1990 end-page: 940 ident: bib12 article-title: Lack of suppression of IgE production by recombinant interferon gamma: a controlled trial in patients with allergic rhinitis publication-title: J Allergy Clin Immunol contributor: fullname: Reed – volume: 140 start-page: 1022 year: 1988 end-page: 1027 ident: bib13 article-title: IFN-gamma regulates the isotype of Ig secreted during in vivo humoral immune responses publication-title: J Immunol contributor: fullname: Mosmann – volume: 144 start-page: 58 year: 1989 end-page: 63 ident: bib2 article-title: New aspects in the pathogenesis of atopic dermatitis publication-title: Acta Derm Venereol Suppl (Stockh) contributor: fullname: Bruijnzeel – volume: 141 start-page: 1218 year: 1988 end-page: 1224 ident: bib3 article-title: IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma publication-title: J Immunol contributor: fullname: Brière – volume: 88 start-page: 365 year: 1990 end-page: 370 ident: bib9 article-title: Recombinant gamma interferon in treatment of patients with atopic dermatitis and elevated IgE levels publication-title: Am J Med contributor: fullname: Izu – volume: 87 start-page: 120 year: 1988 ident: 10.1016/0190-9622(93)70152-J_bib4 article-title: Immunoglobulin E and immunoglobulin G subclass distribution in vivo and relationship to in vitro generation of interferon-gamma and neopterin in patients with severe atopic dermatitis publication-title: Int Arch Allergy Appl Immunol doi: 10.1159/000234661 contributor: fullname: Reinhold – volume: 1 start-page: 1282 year: 1990 ident: 10.1016/0190-9622(93)70152-J_bib8 article-title: Recombinant IFN-gamma in severe atopic dermatitis publication-title: Lancet doi: 10.1016/0140-6736(90)91347-D contributor: fullname: Reinhold – volume: 144 start-page: 13 year: 1989 ident: 10.1016/0190-9622(93)70152-J_bib11 article-title: Grading of the severity of atopic dermatitis publication-title: Acta Derm Venereol Suppl (Stockh) contributor: fullname: Rajka – volume: 85 start-page: 307 year: 1991 ident: 10.1016/0190-9622(93)70152-J_bib16 article-title: Recombinant interferon-gamma inhibits the expression of IL-4 receptors on human lymphocytes publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.1991.tb05724.x contributor: fullname: Byron – volume: 88 start-page: 365 year: 1990 ident: 10.1016/0190-9622(93)70152-J_bib9 article-title: Recombinant gamma interferon in treatment of patients with atopic dermatitis and elevated IgE levels publication-title: Am J Med doi: 10.1016/0002-9343(90)90490-5 contributor: fullname: Boguniewicz – volume: 144 start-page: 58 year: 1989 ident: 10.1016/0190-9622(93)70152-J_bib2 article-title: New aspects in the pathogenesis of atopic dermatitis publication-title: Acta Derm Venereol Suppl (Stockh) contributor: fullname: Bruijnzeel-Koomen – volume: 87 start-page: 58 year: 1991 ident: 10.1016/0190-9622(93)70152-J_bib6 article-title: Shifts in interleukin-4 and interferon-gamma production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(91)90213-8 contributor: fullname: Rousset – volume: 140 start-page: 1022 year: 1988 ident: 10.1016/0190-9622(93)70152-J_bib13 article-title: IFN-gamma regulates the isotype of Ig secreted during in vivo humoral immune responses publication-title: J Immunol doi: 10.4049/jimmunol.140.4.1022 contributor: fullname: Finkelman – volume: 20 start-page: 243 year: 1990 ident: 10.1016/0190-9622(93)70152-J_bib15 article-title: Regulation of human IgE synthesis. I. Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon-gamma publication-title: Eur J Immunol doi: 10.1002/eji.1830200203 contributor: fullname: Chrétien – volume: 141 start-page: 1218 year: 1988 ident: 10.1016/0190-9622(93)70152-J_bib3 article-title: IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma publication-title: J Immunol doi: 10.4049/jimmunol.141.4.1218 contributor: fullname: Pène – volume: 92 start-page: 44 year: 1980 ident: 10.1016/0190-9622(93)70152-J_bib10 article-title: Diagnostic features of atopic dermatitis publication-title: Acta Derm Venereol (Stockh) doi: 10.2340/00015555924447 contributor: fullname: Hanifin – start-page: 379 year: 1990 ident: 10.1016/0190-9622(93)70152-J_bib14 article-title: Immunomodulating effects of interferons: conclusions for therapy contributor: fullname: Brzoska – volume: 79 start-page: 374 year: 1990 ident: 10.1016/0190-9622(93)70152-J_bib5 article-title: Evidence that defective interferon-gamma production in atopic dermatitis patients is due to intrinsic abnormalities publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.1990.tb08098.x contributor: fullname: Reinhold – volume: 85 start-page: 934 year: 1990 ident: 10.1016/0190-9622(93)70152-J_bib12 article-title: Lack of suppression of IgE production by recombinant interferon gamma: a controlled trial in patients with allergic rhinitis publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(90)90080-N contributor: fullname: Li – volume: 4 start-page: 67 year: 1986 ident: 10.1016/0190-9622(93)70152-J_bib1 article-title: Immunoregulatory abnormalities in atopic dermatitis publication-title: Clin Rev Allergy doi: 10.1007/BF02991188 contributor: fullname: Leung – volume: 86 start-page: 444 year: 1991 ident: 10.1016/0190-9622(93)70152-J_bib7 article-title: Functional characterization of skin-infiltrating lymphocytes in atopic dermatitis publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.1991.tb02951.x contributor: fullname: Reinhold |
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Snippet | Background:
Recent results suggest decreased interferon gamma (IFN-γ) but high interleukin 4 (IL-4) production in patients with atopic dermatitis (AD). Because... Recent results suggest decreased interferon gamma (IFN-gamma) but high interleukin 4 (IL-4) production in patients with atopic dermatitis (AD). Because the... BACKGROUNDRecent results suggest decreased interferon gamma (IFN-gamma) but high interleukin 4 (IL-4) production in patients with atopic dermatitis (AD).... |
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SubjectTerms | Adult Biological and medical sciences Dermatitis, Atopic - immunology Dermatitis, Atopic - pathology Dermatitis, Atopic - therapy Drug Tolerance Female Humans Immunoglobulin E - blood Immunoglobulin G - blood Immunoglobulin G - classification Injections, Subcutaneous Interferon-gamma - administration & dosage Interferon-gamma - therapeutic use Male Medical sciences Pharmacology. Drug treatments Pruritus - pathology Pruritus - therapy Recombinant Proteins Remission Induction Skin, nail, hair, dermoskeleton |
Title | Systemic interferon gamma treatment in severe atopic dermatitis |
URI | https://dx.doi.org/10.1016/0190-9622(93)70152-J https://www.ncbi.nlm.nih.gov/pubmed/8315079 https://search.proquest.com/docview/75817408 |
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