Evidence of memory generalization in contextual locomotor sensitization induced by amphetamine

• Published in: Behavioural brain research Vol. 317; pp. 522 - 527
• Main Authors: Engelke, Douglas Senna, Filev, Renato, Mello, Luiz E., Santos-Junior, Jair Guilherme
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2017
• Subjects: Addiction; Amphetamine; Amphetamine - adverse effects; Amphetamine - toxicity; Analysis of Variance; Animals; Behavioral sensitization; Central Nervous System Stimulants - adverse effects; Contextual memory; Disease Models, Animal; Drugs; Generalization (Psychology) - drug effects; Locomotion - drug effects; Male; Memory - drug effects; Mice; Mice, Inbred C57BL; Psychostimulants; Substance Withdrawal Syndrome - etiology; Substance Withdrawal Syndrome - physiopathology; Time Factors; Drugs; Amphetamine; Contextual memory; Addiction; Behavioral sensitization; Psychostimulants
• ISSN: 0166-4328; 1872-7549; 1872-7549
• DOI: 10.1016/j.bbr.2016.10.018

[Display omitted] •After 3days of withdrawal, amphetamine sensitization is context-dependent.•After 28days of withdrawal, animals expressed a generalized locomotor activity in novel context.•Contextual generalization is prevented when sensitization was conducted in a well-known context.•Memory gener...