Association with tryptophan hydroxylase 2 gene polymorphisms and autism spectrum disorders in Korean families

• Published in: Neuroscience research Vol. 73; no. 4; pp. 333 - 336
• Main Authors: Yang, So Young, Yoo, Hee Jeong, Cho, In Hee, Park, Mira, Kim, Soon Ae
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.08.2012
• Subjects: Asian Continental Ancestry Group - genetics; Association; Autism spectrum disorder; Child; Child Development Disorders, Pervasive - genetics; Genetic Predisposition to Disease - genetics; Genotype; Humans; Korea; Linkage Disequilibrium; Polymorphism, Single Nucleotide; Single nucleotide polymorphism; Tryptophan Hydroxylase - genetics; Tryptophan hydroxylase 2 gene; Korea; Tryptophan hydroxylase 2 gene; Association; Single nucleotide polymorphism; Autism spectrum disorder

► The associations between SNPs in TPH2 and Korean ASD were examined. ► We found a significant association at the rs2129575 with ASD susceptibility. ► TPH2 polymorphisms may influence ASD susceptibility and the phenotypic impairments. It was performed a family-based association study of 6 single nuc...