Absolute ethanol renal angioinfarction for control of hypertension
Six patients (11 renal units) underwent ethanol renal angioinfarction for medically uncontrollable hypertension. The mean preablation blood pressure was 1751112 mm Hg despite antihypertensive medications. Five of the patients demonstrated elevated renal veir renin levels prior to angioinfarction. Hy...
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Published in | Urology (Ridgewood, N.J.) Vol. 33; no. 2; pp. 153 - 158 |
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Main Authors | , , , |
Format | Journal Article Conference Proceeding |
Language | English |
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New York, NY
Elsevier Inc
01.02.1989
Elsevier Science |
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Abstract | Six patients (11 renal units) underwent ethanol renal angioinfarction for medically uncontrollable hypertension. The mean preablation blood pressure was 1751112 mm Hg despite antihypertensive medications. Five of the patients demonstrated elevated renal veir renin levels prior to angioinfarction. Hypertension was improved in all 6 patients, during a mean follow-up period of fifty-one months. Systemic hypertension was completely eliminated in 4 patients. Two patients continue to require antihypertensive medication to control their hypertension. There were no major complications directly related to intra-arterial injection of ethanol. Transcatheter renal ablation employing intra-arterial injection of absolute ethanol for control of severe hypertension appears to be a safe and efficacious procedure. It should be considered an alternative to nephrectomy in selected high-risk patients. |
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AbstractList | Six patients (11 renal units) underwent ethanol renal angioinfarction for medically uncontrollable hypertension. The mean preablation blood pressure was 1751112 mm Hg despite antihypertensive medications. Five of the patients demonstrated elevated renal veir renin levels prior to angioinfarction. Hypertension was improved in all 6 patients, during a mean follow-up period of fifty-one months. Systemic hypertension was completely eliminated in 4 patients. Two patients continue to require antihypertensive medication to control their hypertension. There were no major complications directly related to intra-arterial injection of ethanol. Transcatheter renal ablation employing intra-arterial injection of absolute ethanol for control of severe hypertension appears to be a safe and efficacious procedure. It should be considered an alternative to nephrectomy in selected high-risk patients. Six patients (11 renal units) underwent ethanol renal angioinfarction for medically uncontrollable hypertension. The mean preablation blood pressure was 175/112 mm Hg despite antihypertensive medications. Five of the patients demonstrated elevated renal vein renin levels prior to angioinfarction. Hypertension was improved in all 6 patients, during a mean follow-up period of fifty-one months. Systemic hypertension was completely eliminated in 4 patients. Two patients continue to require antihypertensive medication to control their hypertension. There were no major complications directly related to intra-arterial injection of ethanol. Transcatheter renal ablation employing intra-arterial injection of absolute ethanol for control of severe hypertension appears to be a safe and efficacious procedure. It should be considered an alternative to nephrectomy in selected high-risk patients. |
Author | Hawkins, Irvin F. Locke, D.Russell Klimberg, Ira W. Drylie, David M. |
Author_xml | – sequence: 1 givenname: Ira W. surname: Klimberg fullname: Klimberg, Ira W. – sequence: 2 givenname: D.Russell surname: Locke fullname: Locke, D.Russell – sequence: 3 givenname: Irvin F. surname: Hawkins fullname: Hawkins, Irvin F. – sequence: 4 givenname: David M. surname: Drylie fullname: Drylie, David M. |
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Cites_doi | 10.1016/S0002-9610(73)80012-1 10.1148/radiology.145.2.7134432 10.2214/ajr.124.3.428 10.1056/NEJM196905012801802 10.1148/radiology.150.3.6695065 10.1148/93.2.434 10.2214/ajr.146.3.593 10.1148/radiology.141.3.7302214 10.1097/00000658-197306000-00015 10.2214/ajr.127.3.389 10.1148/radiology.138.2.6779345 10.1259/0007-1285-46-543-222 10.1111/j.1464-410X.1973.tb06806.x 10.1148/radiology.154.2.3966123 10.1016/0002-9610(75)90332-3 10.1016/S0022-5347(17)59132-6 10.1148/radiology.148.1.6856864 10.1148/128.1.45 10.1007/BF02552398 10.2214/ajr.133.4.647 10.2214/ajr.136.3.493 10.1148/radiology.145.1.7122894 10.1016/S0022-5347(17)48768-4 10.1016/0090-4295(78)90111-5 10.1097/00004424-198007000-00008 |
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Keywords | Human Hypertension Urinary system disease Ethanol Cardiovascular disease Embolization Kidney |
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surgical management of renovascular hypertension publication-title: Ann Surg doi: 10.1097/00000658-197306000-00015 contributor: fullname: Foster – volume: 127 start-page: 389 year: 1976 ident: 10.1016/0090-4295(89)90018-6_BIB7 article-title: Embolic control of hypertension caused by segmental renal artery stenosis publication-title: AJR doi: 10.2214/ajr.127.3.389 contributor: fullname: Reuter – volume: 138 start-page: 333 year: 1981 ident: 10.1016/0090-4295(89)90018-6_BIB27 article-title: The use of iodinated contrast agents to ablate organs: experimental studies and histopathology publication-title: Radiology doi: 10.1148/radiology.138.2.6779345 contributor: fullname: Doppman – volume: 46 start-page: 222 year: 1973 ident: 10.1016/0090-4295(89)90018-6_BIB8 article-title: Renal arteriovenous fistula by catheter embolization publication-title: Br J Radiol doi: 10.1259/0007-1285-46-543-222 contributor: fullname: Rizk – volume: 194 start-page: 1406 year: 1976 ident: 10.1016/0090-4295(89)90018-6_BIB15 article-title: Distal embolization complicating therapeutic renal infarction publication-title: N Engl J Med contributor: fullname: Bergreen – volume: 45 start-page: 474 year: 1973 ident: 10.1016/0090-4295(89)90018-6_BIB12 article-title: Treatment of renal adenocarcinoma by embolic occlusion of the renal circulation publication-title: Br J Urol doi: 10.1111/j.1464-410X.1973.tb06806.x contributor: fullname: Almgard – volume: 154 start-page: 357 year: 1985 ident: 10.1016/0090-4295(89)90018-6_BIB24 article-title: Absolute ethanol injection of the adrenal artery: hypertensive reaction publication-title: Radiology doi: 10.1148/radiology.154.2.3966123 contributor: fullname: Fink – volume: 129 start-page: 616 year: 1975 ident: 10.1016/0090-4295(89)90018-6_BIB4 article-title: Lethal complications of bilateral nephrectomy and splenectomy in hemodialyzed patients publication-title: Am J Surg doi: 10.1016/0002-9610(75)90332-3 contributor: fullname: Matas – volume: 115 start-page: 203 year: 1976 ident: 10.1016/0090-4295(89)90018-6_BIB9 article-title: Management of postoperative renal hemorrhage by transcatheter embolization publication-title: J Urol doi: 10.1016/S0022-5347(17)59132-6 contributor: fullname: Kaufman – volume: 148 start-page: 51 year: 1983 ident: 10.1016/0090-4295(89)90018-6_BIB17 article-title: Control of hypertension by ethanol renal ablation publication-title: Radiology doi: 10.1148/radiology.148.1.6856864 contributor: fullname: Nanni – volume: 128 start-page: 45 year: 1978 ident: 10.1016/0090-4295(89)90018-6_BIB22 article-title: Gelfoam embolization of the kidneys for treatment of malignant hypertension publication-title: Radiology doi: 10.1148/128.1.45 contributor: fullname: Adler – volume: 4 start-page: 1 year: 1981 ident: 10.1016/0090-4295(89)90018-6_BIB19 article-title: Transcatheter obliteration of renal artery by ethanol injection: experimental results publication-title: Cardiovasc Intervent Radiol doi: 10.1007/BF02552398 contributor: fullname: Ekelund – volume: 133 start-page: 647 year: 1979 ident: 10.1016/0090-4295(89)90018-6_BIB13 article-title: Transcatheter occlusive therapy of genitourinary abnormalities using isobutyl vn]2 cyanoacrylate (Bucrylate) publication-title: AJR doi: 10.2214/ajr.133.4.647 contributor: fullname: Freeny – volume: 136 start-page: 493 year: 1981 ident: 10.1016/0090-4295(89)90018-6_BIB18 article-title: Experimental renal infarcts: angiographic and histologic studies publication-title: AJR doi: 10.2214/ajr.136.3.493 contributor: fullname: Cho – volume: 145 start-page: 45 year: 1982 ident: 10.1016/0090-4295(89)90018-6_BIB21 article-title: Early mechanism of action of arterially infused alcohol U.S.P. in renal devitalization publication-title: Radiology doi: 10.1148/radiology.145.1.7122894 contributor: fullname: Buchta – volume: 133 start-page: 21 year: 1985 ident: 10.1016/0090-4295(89)90018-6_BIB10 article-title: Preoperative angioinfarction of localized renal cell carcinoma using absolute ethanol publication-title: J Urol doi: 10.1016/S0022-5347(17)48768-4 contributor: fullname: Klimberg – volume: 11 start-page: 197 year: 1978 ident: 10.1016/0090-4295(89)90018-6_BIB6 article-title: Percutaneous infarction of renal tumors: comparison between gelatin sponge embolization and cyanocrylate occlusion publication-title: Urology doi: 10.1016/0090-4295(78)90111-5 contributor: fullname: Goldin – volume: 15 start-page: 318 year: 1986 ident: 10.1016/0090-4295(89)90018-6_BIB20 article-title: Renal infarction with absolute alcohol publication-title: Invest Radiol doi: 10.1097/00004424-198007000-00008 contributor: fullname: Ellman |
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Snippet | Six patients (11 renal units) underwent ethanol renal angioinfarction for medically uncontrollable hypertension. The mean preablation blood pressure was... |
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SubjectTerms | Adult Antihypertensive Agents - therapeutic use Biological and medical sciences Child Embolization, Therapeutic Ethanol - therapeutic use Female Humans Hypertension, Renal - therapy Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Renal Artery Renovascular diseases |
Title | Absolute ethanol renal angioinfarction for control of hypertension |
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