Substrate-Induced Up-Regulation of Aldose Reductase by Methylglyoxal, a Reactive Oxoaldehyde Elevated in Diabetes

• Published in: Molecular pharmacology Vol. 61; no. 5; pp. 1184 - 1191
• Main Authors: Chang, Ki Churl, Paek, Kyung Shin, Kim, Hyo Jung, Lee, Young Soo, Yabe-Nishimura, Chihiro, Seo, Han Geuk
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.05.2002
• Subjects: Aldehyde Reductase - genetics; Aldehyde Reductase - metabolism; Animals; Cell Survival - drug effects; Diabetes Mellitus - enzymology; Diabetes Mellitus - metabolism; Enzyme Activation; Mitogen-Activated Protein Kinases - metabolism; Muscle, Smooth - drug effects; Muscle, Smooth - pathology; p38 Mitogen-Activated Protein Kinases; Pyruvaldehyde - pharmacology; Rats; Reactive Oxygen Species; RNA, Messenger - drug effects; RNA, Messenger - metabolism; Substrate Specificity; Up-Regulation - drug effects

Methylglyoxal (MG), a reactive dicarbonyl produced during glucose metabolism, induced a dose- and time-dependent increase in aldose reductase (AR) mRNA level in rat aortic smooth muscle cells (SMCs). AR has been implicated in the pathogenesis of diabetic complications, whereas the clinical efficacy...