THE INHIBITORY EFFECT OF 2-THIENYL 2′-HYDROXYPHENYL KETONE (C85) ON PLATELET THROMBOXANE FORMATION

• Published in: Thrombosis research Vol. 84; no. 2; pp. 83 - 95
• Main Authors: Chou, Tz-Chong, Hsu, Ling-Yih, Yen, Mao-Hsiung, Ding, Yu-An
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 15.10.1996; Elsevier Science
• Subjects: 2-heteroaryl 2′-substituted-phenyl ketone derivatives; Adenosine Triphosphate - metabolism; Animals; Biological and medical sciences; Blood Platelets - drug effects; Blood Platelets - physiology; Blood. Blood coagulation. Reticuloendothelial system; Calcium - metabolism; cyclooxygenase activity; Dinoprostone - biosynthesis; Fura-2; Humans; Ketones - chemistry; Ketones - pharmacology; Medical sciences; Mice; Pharmacology. Drug treatments; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - chemistry; Platelet Aggregation Inhibitors - pharmacology; platelet function; Rabbits; Thiophenes - chemistry; Thiophenes - pharmacology; Thromboxane A 2; Thromboxane B2 - biosynthesis; Thromboxane A 2; cyclooxygenase activity; 2-heteroaryl 2′-substituted-phenyl ketone derivatives; platelet function; Human; Prostaglandin-endoperoxide synthase; Intramolecular oxidoreductases; Enzyme; Enzyme inhibitor; Ketone; In vitro; Antiplatelet agent; Aggregation; Platelet; Isomerases; Thromboxane-A synthase; Oxidoreductases; Mechanism of action

A new synthetic compound, 2-thienyl 2′-hydroxyphenyl ketone (C85), was demonstrated as an antiplatelet agent. In rabbit washed platelets, C85 dose-dependently inhibited arachidonic acid(AA), collagen and platelet activating factor(PAF)-induced platelet aggregation and ATP release with IC 50 values o...