Merkel cell carcinoma: In vitro and in vivo characteristics of a new cell line

• Published in: Journal of the American Academy of Dermatology Vol. 29; no. 5; pp. 715 - 722
• Main Authors: Ronan, Salve G., Green, Albert D., Shilkaitis, Anne, Huang, Tien-Shew W., Das Gupta, T.K.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.11.1993; Elsevier
• Subjects: Animals; Biological and medical sciences; Carcinoma, Merkel Cell - genetics; Carcinoma, Merkel Cell - pathology; Carcinoma, Merkel Cell - ultrastructure; Cell Line, Transformed; Dermatology; Female; Humans; Immunohistochemistry; Karyotyping; Male; Medical sciences; Mice; Mice, Nude; Microscopy, Electron; Middle Aged; Neoplasm Transplantation; Skin Neoplasms - genetics; Skin Neoplasms - pathology; Skin Neoplasms - ultrastructure; Translocation, Genetic; Tumors of the skin and soft tissue. Premalignant lesions; Human; Animal model; Skin disease; Carcinoma; Merkel cell; Rodentia; Epidermis; Malignant tumor; Heterograft; In vitro; Pathology; In vivo; Vertebrata; Experimental disease; Mammalia; Cell line; Mouse; Graft surgical

Background : Few studies exist that describe Merkel cell carcinoma (MCC) growth characteristics in vitro, in vivo, or both. Objective : Our purpose was to evaluate the pathologic features of MCC implanted into athymic mice and to determine cytogenetic abnormalities in the established cell line. Meth...