Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway

• Published in: Molecular and cellular endocrinology Vol. 500; p. 110628
• Main Authors: Ren, Huiwen, Shao, Ying, Wu, Can, Ma, Xiaoyu, Lv, Chuan, Wang, Qiuyue
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.01.2020
• Subjects: AMP-activated protein kinase; animal disease models; Autophagy; cell proliferation; Diabetic kidney disease; glucose; glycolipids; high fat diet; kidney diseases; lipid metabolism; Metformin; noninsulin-dependent diabetes mellitus; Oxidative stress; protective effect; rats; renal function; small interfering RNA; streptozotocin; therapeutics; Oxidative stress; Metformin; Autophagy; Diabetic kidney disease

Metformin, as the basic pharmacological therapy and the first preventive drug in type 2 diabetes mellitus (T2DM), is proved to have potential protection in diabetic kidney disease (DKD). Here, we established a diabetic rat model induced by high-fat diet and low dose streptozotocin, and high glucose...