Mortality from coronary heart disease and cerebrovascular disease and associated risk factors in diabetic patients in Osaka District, Japan

• Published in: Diabetes research and clinical practice Vol. 27; no. 1; pp. 77 - 83
• Main Authors: Sasaki, Akira, Horiuchi, Naruto, Hasegawa, Kyoichi, Uehara, Masuko
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 1995; Elsevier Science
• Subjects: Adult; Aged; Albuminuria; Associated diseases and complications; Biological and medical sciences; Blood Glucose - metabolism; Blood Pressure; Cerebrovascular disease; Cerebrovascular Disorders - blood; Cerebrovascular Disorders - mortality; Cerebrovascular Disorders - physiopathology; Cholesterol - blood; Coronary Disease - blood; Coronary Disease - mortality; Coronary Disease - physiopathology; Coronary heart disease; Diabetes Mellitus - blood; Diabetes Mellitus - mortality; Diabetes Mellitus - physiopathology; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - mortality; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - blood; Diabetic Angiopathies - mortality; Diabetic Angiopathies - physiopathology; Diabetic Retinopathy - mortality; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Follow-Up Studies; Humans; Japan - epidemiology; Male; Medical sciences; Middle Aged; NIDDM; Obesity; Risk factor; Risk Factors; Serum cholesterol; Sex Characteristics; Sex Factors; Smoking; Time Factors; Triglycerides - blood; Asia; Japan; Serum cholesterol; Coronary heart disease; Cerebrovascular disease; Risk factor; NIDDM; Endocrinopathy; Vascular disease; Human; Nervous system diseases; Mortality; Central nervous system disease; Cardiovascular disease; Non insulin dependent diabetes; Cerebral disorder
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/0168-8227(94)01018-U

Mortality from coronary heart disease (CHD) and cerebrovascular disease (CVD), as well as associated risk factors, were examined. The subjects studied were 1939 non-insulin-dependent diabetic (NIDDM) patients and 503 deaths were observed during a mean follow-up period of 9.4 years. Of these deaths, 62 were CHD deaths and 84 were CVD deaths. The mortality rates per 1000 person-years from CHD were 3.95 for males and 2.57 for females and those from CVD were 5.12 and 3.86 for males and females, respectively, showing a higher mortality for males and an increasing trend with age. The baseline factors associated with CHD mortality were age at entry into the study, hypertension, ischemic ECG changes, serum cholesterol level, diabetic retinopathy and albuminuria, while those associated with CVD were age at entry, hypertension, ischemic ECG changes, diabetic retinopathy, albuminuria and therapeutic regimen, all of which were found to be significant by univariate analysis. The relationships were further analyzed by the multiple logistic method. In addition, the baseline characteristics of the patients who died of CHD and CVD were compared with those of patients who died from other causes. The baseline characteristics in cases of deaths from CHD and CVD were significantly different from those of deaths from other causes in terms of obesity, ischemic ECG changes, serum cholesterol level and serum triglycerides level for deaths from CHD and in terms of age at onset, age at death and hypertension for deaths from CVD.