B cell autoimmunity to acetylcholine receptor and its subunits in Lewis rats over the course of experimental autoimmune myasthenia gravis

• Published in: Journal of neuroimmunology Vol. 45; no. 1; pp. 103 - 112
• Main Authors: Wang, Z.-Y., Link, H., Qiao, J., Olsson, T., Huang, W.-X.
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 01.06.1993; Amsterdam Elsevier; New York, NY
• Subjects: Acetylcholine receptor subunits; Animals; Antibodies - analysis; Autoantibodies; Autoimmune Diseases - immunology; Autoimmunity; B cell immunity; B-Lymphocytes - immunology; Biological and medical sciences; Diseases of striated muscles. Neuromuscular diseases; Female; Immunoglobulin G - immunology; Lymphoid Tissue - immunology; Medical sciences; Myasthenia gravis; Myasthenia Gravis - immunology; Neurology; Radioimmunoassay; Rats; Rats, Inbred Lew; Receptors, Cholinergic - classification; Receptors, Cholinergic - immunology; Thymus; Torpedo; Acetylcholine receptor subunits; Autoantibodies; Myasthenia gravis; B cell immunity; Thymus; Autoimmunity; Immunopathology; Animal model; Neuromuscular diseases; Nervous system diseases; Immune response; Rat; Pathogenesis; Rodentia; Autoimmune disease; B-Lymphocyte; Injection; Mechanism; Vertebrata; Experimental disease; Cholinergic receptor; Specificity; Mammalia; Humoral immunity

Experimental autoimmune myasthenia gravis (EAMG) is induced by a single injection of acetylcholine receptor (AChR) with complete Freund's adjuvant and represents a useful animal model for studying the mechanisms by which autoimmune responses to AChR and its subunits are coupled to the developme...