Consequences of constitutive deletion of melanin-concentrating hormone-1 receptors for feeding and foraging behaviors of mice

• Published in: Behavioural brain research Vol. 316; pp. 271 - 278
• Main Authors: Eiler, William J.A., Chen, Yanyun, Slieker, Lawrence J., Ardayfio, Paul A., Statnick, Michael A., Witkin, Jeffrey M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2017
• Subjects: Animals; Animals, Newborn; Biophysics; Conditioning, Operant - physiology; Eating - genetics; Electric Stimulation; Feeding; Feeding Behavior - physiology; Female; Food; Food Deprivation; Male; MCH1; Mice; Mice, Transgenic; Motivation; Mouse; Quinine - administration & dosage; Receptors, Somatostatin - deficiency; Receptors, Somatostatin - genetics; Reinforcement (Psychology); Satiation - physiology; MCH1; Motivation; Mouse; Feeding

•MCH1 −/− mice exhibited increased motivation to obtain food compared to WT mice.•Increased food-seeking in MCH1−/− mice was also observed when behavior was punished.•Feeding in MCH1 −/− mice contrasts in some important dimensions from data reported with MCH1 receptor antagonism. In order to deciphe...