LncRNA MIR99AHG enhances adipocyte differentiation by targeting miR-29b-3p to upregulate PPARγ

• Published in: Molecular and cellular endocrinology Vol. 550; p. 111648
• Main Authors: Zhang, Lin, Ma, Jinfang, Pan, Xiaohui, Zhang, Mei, Huang, Wei, Liu, Yanjun, Yang, Huawu, Cheng, Zhong, Zhang, Guixiang, Qie, Mingrong, Tong, Nanwei
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.06.2022
• Subjects: adipocytes; Adipogenesis; adipose tissue; body mass index; caudal vein; endocrinology; epididymis; fatty acids; high fat diet; humans; microRNA; miR-29b-3p; MIR99AHG; Obesity; peroxisome proliferator-activated receptor gamma; small interfering RNA; therapeutics; lncRNAs; microRNAs; Obesity; C/EBPα; FABP4; miR-29b-3p; MIR99AHG; VAT; PPARγ; Adipogenesis

The aim is to identify new long noncoding RNAs (lncRNAs) involved in adipocyte differentiation. High-throughput RNA sequencing of 3T3-L1 preadipocytes was carried out before and after differentiation to identify the target lncRNAs and miRNAs. The effects of lncRNA, miRNA and the network mechanism on...