Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: Analysis of 101 published survival curves

One hundred and one published survival curves for 92 human cell lines (including 64 tumor lines) have been analyzed in terms of several parameters that are supposed to characterize cell radiosensitivity. Values for n, D o , α and β (from the linear quadratic model), D (Mean Inactivation Dose), and s...

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Published inInternational journal of radiation oncology, biology, physics Vol. 11; no. 9; pp. 1699 - 1707
Main Authors Fertil, B, Malaise, E.P
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.09.1985
Elsevier
Subjects
Biological and medical sciences
Cell Line
Cell Survival - radiation effects
Dose effect relationship
Human
Humans
In vitro
Mean inactivation dose
Medical sciences
Neoplasms - pathology
Neoplasms - radiotherapy
Radiation therapy and radiosensitizing agent
Radiation Tolerance
Radioresponsiveness
Radiosensitivity
Survival Curves
Treatment with physical agents
Treatment. General aspects
Tumors
Human
Dose effect relationship
Radiosensitivity
Survival Curves
Radioresponsiveness
Model
In vitro
Mean inactivation dose
Cell culture
Correlation
Cell line
Biological model
Tumor
Experimental study
Radiotherapy
Tumor cell
Survival curve
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Abstract One hundred and one published survival curves for 92 human cell lines (including 64 tumor lines) have been analyzed in terms of several parameters that are supposed to characterize cell radiosensitivity. Values for n, D o , α and β (from the linear quadratic model), D (Mean Inactivation Dose), and survivals at 2 Gy and 8 Gy have been obtained for each curve. It was found that: I. the initial part of the survival curve is specific to the corresponding cell line; II. this initial part is well characterized by the parameters a and D , the values of which can be used to compare intrinsic radiosensitivity among human cell lines; III. human tumor cell line radiosensitivity (expressed in terms of α, D and survival at 2 Gy) reflects the clinical radioresponsiveness of the tumors from which the cell lines are derived. Thus, cells from tumors with low radioresponsiveness (melanomas and glioblastomas) are the less radiosensitive. Furthermore, the range of survival at a dose of 2 Gy is broad enough to account, in large measure, for observed differences in clinical tumor radioresponsiveness.
AbstractList One hundred and one published survival curves for 92 human cell lines (including 64 tumor lines) have been analyzed in terms of several parameters that are supposed to characterize cell radiosensitivity. Values for n, Do, alpha and beta (from the linear quadratic model), D (Mean Inactivation Dose), and survivals at 2 Gy and 8 Gy have been obtained for each curve. It was found that: I. the initial part of the survival curve is specific to the corresponding cell line; II. this initial part is well characterized by the parameters alpha and D, the values of which can be used to compare intrinsic radiosensitivity among human cell lines; III. human tumor cell line radiosensitivity (expressed in terms of alpha, D and survival at 2 Gy) reflects the clinical radioresponsiveness of the tumors from which the cell lines are derived. Thus, cells from tumors with low radioresponsiveness (melanomas and glioblastomas) are the less radiosensitive. Furthermore, the range of survival at a dose of 2 Gy is broad enough to account, in large measure, for observed differences in clinical tumor radioresponsiveness.
One hundred and one published survival curves for 92 human cell lines (including 64 tumor lines) have been analyzed in terms of several parameters that are supposed to characterize cell radiosensitivity. Values for n, D o , α and β (from the linear quadratic model), D (Mean Inactivation Dose), and survivals at 2 Gy and 8 Gy have been obtained for each curve. It was found that: I. the initial part of the survival curve is specific to the corresponding cell line; II. this initial part is well characterized by the parameters a and D , the values of which can be used to compare intrinsic radiosensitivity among human cell lines; III. human tumor cell line radiosensitivity (expressed in terms of α, D and survival at 2 Gy) reflects the clinical radioresponsiveness of the tumors from which the cell lines are derived. Thus, cells from tumors with low radioresponsiveness (melanomas and glioblastomas) are the less radiosensitive. Furthermore, the range of survival at a dose of 2 Gy is broad enough to account, in large measure, for observed differences in clinical tumor radioresponsiveness.
Author Fertil, B
Malaise, E.P
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  fullname: Fertil, B
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  surname: Malaise
  fullname: Malaise, E.P
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8616581$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/4030437$$D View this record in MEDLINE/PubMed
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IsPeerReviewed true
IsScholarly true
Issue 9
Keywords Human
Dose effect relationship
Radiosensitivity
Survival Curves
Radioresponsiveness
Model
In vitro
Mean inactivation dose
Cell culture
Correlation
Cell line
Biological model
Tumor
Experimental study
Radiotherapy
Tumor cell
Survival curve
Language English
License CC BY 4.0
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PublicationTitle International journal of radiation oncology, biology, physics
PublicationTitleAlternate Int J Radiat Oncol Biol Phys
PublicationYear 1985
Publisher Elsevier Inc
Elsevier
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SSID ssj0001174
Score 1.7424314
Snippet One hundred and one published survival curves for 92 human cell lines (including 64 tumor lines) have been analyzed in terms of several parameters that are...
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SubjectTerms Biological and medical sciences
Cell Line
Cell Survival - radiation effects
Dose effect relationship
Human
Humans
In vitro
Mean inactivation dose
Medical sciences
Neoplasms - pathology
Neoplasms - radiotherapy
Radiation therapy and radiosensitizing agent
Radiation Tolerance
Radioresponsiveness
Radiosensitivity
Survival Curves
Treatment with physical agents
Treatment. General aspects
Tumors
Title Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: Analysis of 101 published survival curves
URI https://dx.doi.org/10.1016/0360-3016(85)90223-8
https://www.ncbi.nlm.nih.gov/pubmed/4030437
https://search.proquest.com/docview/76278335
Volume 11
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