Nonspecific immunity and head and neck cancer: blastogenesis reviewed and revisited

The present study suggests a correlation between concanavalin A-driven blastogenesis and the clinical course of head and neck cancer. Blastogenesis assays were conducted on peripheral blood lymphocytes from controls and from patients with squamous cell carcinoma (SCC) of the head and neck. Our resul...

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Published inOral surgery, oral medicine, oral pathology Vol. 60; no. 6; pp. 642 - 647
Main Authors Eskinazi, Daniel P., Helman, Joseph, Ershow, Abby G., Perna, John J., Mihail, Radu
Format Journal Article
LanguageEnglish
Published Saint Louis, MO Elsevier Inc 01.12.1985
Mosby
Subjects
Adult
Aged
Biological and medical sciences
Carcinoma, Squamous Cell - immunology
Concanavalin A - pharmacology
Dentistry
Female
Head and Neck Neoplasms - immunology
Humans
Lymphocyte Activation - drug effects
Lymphocytes - drug effects
Lymphocytes - immunology
Male
Medical sciences
Middle Aged
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Phytohemagglutinins - pharmacology
Prognosis
Human
Head and neck
ENT disease
Tumor
Non specific immunity
Immunology
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Abstract The present study suggests a correlation between concanavalin A-driven blastogenesis and the clinical course of head and neck cancer. Blastogenesis assays were conducted on peripheral blood lymphocytes from controls and from patients with squamous cell carcinoma (SCC) of the head and neck. Our results indicated that 3H-thymidine incorporation in response to concanavalin A and phytohemagglutinin stimulation were significantly lower for patients' than for controls' lymphocytes, whereas PWM stimulation was not statistically different in these two groups. Differences between patients and controls were most notable with concanavalin A stimulation. Five of seventeen patients had a response to concanavalin A stimulation that was in the normal range when expressed as relative to control values. The clinical course of these five patients seems to point to a better prognosis than that of the remaining patients who had below-normal mitogenic responses.
AbstractList The present study suggests a correlation between concanavalin A-driven blastogenesis and the clinical course of head and neck cancer. Blastogenesis assays were conducted on peripheral blood lymphocytes from controls and from patients with squamous cell carcinoma (SCC) of the head and neck. Our results indicated that 3H-thymidine incorporation in response to concanavalin A and phytohemagglutinin stimulation were significantly lower for patients' than for controls' lymphocytes, whereas PWM stimulation was not statistically different in these two groups. Differences between patients and controls were most notable with concanavalin A stimulation. Five of seventeen patients had a response to concanavalin A stimulation that was in the normal range when expressed as relative to control values. The clinical course of these five patients seems to point to a better prognosis than that of the remaining patients who had below-normal mitogenic responses.
The present study suggests a correlation between concanavalin A-driven blastogenesis and the clinical course of head and neck cancer. Blastogenesis assays were conducted on peripheral blood lymphocytes from controls and from patients with squamous cell carcinoma (SCC) of the head and neck. Our results indicated that 3H-thymidine incorporation in response to concanavalin A and phytohemagglutinin stimulation were significantly lower for patients' than for controls' lymphocytes, whereas PWM stimulation was not statistically different in these two groups. Differences between patients and controls were most notable with concanavalin A stimulation. Five of seventeen patients had a response to concanavalin A stimulation that was in the normal range when expressed as relative to control values. The clinical course of these five patients seems to point to a better prognosis than that of the remaining patients who had below-normal mitogenic responses.
Author Ershow, Abby G.
Eskinazi, Daniel P.
Perna, John J.
Helman, Joseph
Mihail, Radu
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Cites_doi 10.1002/1097-0142(196706)20:6<1015::AID-CNCR2820200612>3.0.CO;2-K
10.1001/archotol.1983.00800160017004
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ENT disease
Tumor
Non specific immunity
Immunology
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Snippet The present study suggests a correlation between concanavalin A-driven blastogenesis and the clinical course of head and neck cancer. Blastogenesis assays were...
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SubjectTerms Adult
Aged
Biological and medical sciences
Carcinoma, Squamous Cell - immunology
Concanavalin A - pharmacology
Dentistry
Female
Head and Neck Neoplasms - immunology
Humans
Lymphocyte Activation - drug effects
Lymphocytes - drug effects
Lymphocytes - immunology
Male
Medical sciences
Middle Aged
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Phytohemagglutinins - pharmacology
Prognosis
Title Nonspecific immunity and head and neck cancer: blastogenesis reviewed and revisited
URI https://dx.doi.org/10.1016/0030-4220(85)90368-8
https://www.ncbi.nlm.nih.gov/pubmed/3865136
https://search.proquest.com/docview/76490766
Volume 60
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