Aggregated IgG bind to glomerular epithelial cells to stimulate urokinase release through an endocytosis-independent process

• Published in: Nephron Vol. 98; no. 1; p. e13
• Main Authors: Haymann, Jean-Philippe, Delarue, Françoise, Baud, Laurent, Sraer, Jean-Daniel
• Format: Journal Article
• Language: English
• Published: Switzerland S. Karger AG 01.01.2004
• Subjects: Binding Sites, Antibody; Cell Line; Cells, Cultured; Endocytosis - physiology; Epithelial Cells - enzymology; Epithelial Cells - immunology; Histocompatibility Antigens Class I; Humans; Immunoglobulin G - metabolism; Kidney Glomerulus - cytology; Kidney Glomerulus - immunology; Kidney Glomerulus - metabolism; Plasminogen Activator Inhibitor 1; Receptors, Fc - metabolism; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator - biosynthesis; Urokinase-Type Plasminogen Activator - metabolism

In membranous nephropathy, the development of glomerular lesions is related to the formation of immune complexes at subepithelial sites. These deposits are associated with modifications in the fibrinolytic activity of glomerular cells leading to the appearance of fibrin degradation products in the d...