Neuropsychological dysfunction in parents of schizophrenics
Neuropsychological measures designed to examine aspects of attention, learning efficiency, and memory were investigated in 14 schizophrenic probands, their 28 parents, and 18 normal individuals. Probands performed at levels significantly below normals on measures of attention and of learning efficie...
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Published in | Schizophrenia research Vol. 20; no. 3; pp. 253 - 260 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
05.07.1996
Elsevier Science |
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Abstract | Neuropsychological measures designed to examine aspects of attention, learning efficiency, and memory were investigated in 14 schizophrenic probands, their 28 parents, and 18 normal individuals. Probands performed at levels significantly below normals on measures of attention and of learning efficiency and performed below their parents on a subset of the same measures. Eight families had one parent with a personal or ancestral pedigree history consistent with schizophrenia; the other parent's personal and ancestral history was negative for schizophrenia. In these families, the probands were significantly different from the negative-history parents, but not the positive-history parents on an aggregate index of attention. Schizophrenics were significantly different from both the positive- and negative-history parents on an aggregate index of learning efficiency. These results extend previous findings of specific neuropsychological dysfunction in attention and learning in schizophrenics to show that some of the deficits are present in a subgroup of their parents, those who are likely carriers of genes conveying risk for schizophrenia. The data suggest that a heritable component of the neuropsychological deficit is a primary dysfunction in attention, and that a secondary or additional deficit in learning may be evident in family members who actually express the disorder of schizophrenia. |
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AbstractList | Neuropsychological measures designed to examine aspects of attention, learning efficiency, and memory were investigated in 14 schizophrenic probands, their 28 parents, and 18 normal individuals. Probands performed at levels significantly below normals on measures of attention and of learning efficiency and performed below their parents on a subset of the same measures. Eight families had one parent with a personal or ancestral pedigree history consistent with schizophrenia; the other parent's personal and ancestral history was negative for schizophrenia. In these families, the probands were significantly different from the negative-history parents, but not the positive-history parents on an aggregate index of attention. Schizophrenics were significantly different from both the positive- and negative-history parents on an aggregate index of learning efficiency. These results extend previous findings of specific neuropsychological dysfunction in attention and learning in schizophrenics to show that some of the deficits are present in a subgroup of their parents, those who are likely carriers of genes conveying risk for schizophrenia. The data suggest that a heritable component of the neuropsychological deficit is a primary dysfunction in attention, and that a secondary or additional deficit in learning may be evident in family members who actually express the disorder of schizophrenia. |
Author | Cullum, C.Munro Rilling, Laurie M. Adler, Lawrence E. Cicerello, Antoinette Freedman, Robert Harris, Josette G. Intemann, Peter M. Young, David A. |
Author_xml | – sequence: 1 givenname: Josette G. surname: Harris fullname: Harris, Josette G. – sequence: 2 givenname: Lawrence E. surname: Adler fullname: Adler, Lawrence E. – sequence: 3 givenname: David A. surname: Young fullname: Young, David A. – sequence: 4 givenname: C.Munro surname: Cullum fullname: Cullum, C.Munro – sequence: 5 givenname: Laurie M. surname: Rilling fullname: Rilling, Laurie M. – sequence: 6 givenname: Antoinette surname: Cicerello fullname: Cicerello, Antoinette – sequence: 7 givenname: Peter M. surname: Intemann fullname: Intemann, Peter M. – sequence: 8 givenname: Robert surname: Freedman fullname: Freedman, Robert |
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Keywords | Schizophrenia Neuropsychological dysfunction Parents Learning efficiency Learning Human Psychosis Family study Parent Memory Attention Neuropsychological test Psychometrics Cognition Heritability |
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SubjectTerms | Adult Attention Biological and medical sciences Child of Impaired Parents - psychology Family environment. Family history Female Humans Learning efficiency Male Medical sciences Mental Recall Neurocognitive Disorders - diagnosis Neurocognitive Disorders - genetics Neurocognitive Disorders - psychology Neuropsychological dysfunction Neuropsychological Tests Parents Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reference Values Risk Factors Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenic Psychology Social psychiatry. Ethnopsychiatry |
Title | Neuropsychological dysfunction in parents of schizophrenics |
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