Identification, expression, and innate immune responses of two insulin-like peptide genes in the razor clam Sinonovacula constricta

Insulin-like peptide (ILP) has emerged as a cell regulatory factor with multiple functions in vertebrates and invertebrates. In the present study, we identified and characterized two ILP genes, ILP1 and ILP2, in the razor clam Sinonovacula constricta. Both ILPs have a signal peptide and a mature dom...

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Published inFish & shellfish immunology Vol. 51; pp. 401 - 404
Main Authors Niu, Donghong, Wang, Fei, Zhao, Honggang, Wang, Ze, Xie, Shumei, Li, Jiale
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2016
Subjects
Animals
Bacterial Infections - genetics
Bacterial Infections - immunology
Bacterial Infections - veterinary
Bivalvia - genetics
Bivalvia - immunology
Hemocytes - metabolism
ILP
Immunity, Innate
Innate immunity
Insulin-like peptide
Liver - metabolism
Micrococcus
Micrococcus lysodeikticus
Peptide Hormones - genetics
Peptide Hormones - immunology
Phylogeny
Sinonovacula constricta
Vibrio
Vibrio anguillarum
Vibrio parahaemolyticus
Innate immunity
ILP
Insulin-like peptide
Sinonovacula constricta
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Abstract Insulin-like peptide (ILP) has emerged as a cell regulatory factor with multiple functions in vertebrates and invertebrates. In the present study, we identified and characterized two ILP genes, ILP1 and ILP2, in the razor clam Sinonovacula constricta. Both ILPs have a signal peptide and a mature domain consisting of six strictly conserved cysteines. The tertiary structure is divided into three main α-helices with a C-domain loop that separates helix 1 from helix 2. Both of ILPs were found to be regulated according to tissue type and developmental stage. After challenge with Vibrio anguillarum, Vibrio parahaemolyticus and Micrococcus lysodeikticus, the expression of two ILP genes was significantly up-regulated in the liver, hemocytes and mantle tissues, suggesting that the ILPs may play roles in the innate immunity in the razor clam Sinonovacula constricta. •Two insulin-like peptide (ILP) genes were characterized from the razor clam Sinonovacula constricta.•The ILP transcripts were widely expressed in adult tissues and the early developmental stages.•The expression of the two ILP genes was significantly up-regulated after infection.
AbstractList Insulin-like peptide (ILP) has emerged as a cell regulatory factor with multiple functions in vertebrates and invertebrates. In the present study, we identified and characterized two ILP genes, ILP1 and ILP2, in the razor clam Sinonovacula constricta. Both ILPs have a signal peptide and a mature domain consisting of six strictly conserved cysteines. The tertiary structure is divided into three main α-helices with a C-domain loop that separates helix 1 from helix 2. Both of ILPs were found to be regulated according to tissue type and developmental stage. After challenge with Vibrio anguillarum, Vibrio parahaemolyticus and Micrococcus lysodeikticus, the expression of two ILP genes was significantly up-regulated in the liver, hemocytes and mantle tissues, suggesting that the ILPs may play roles in the innate immunity in the razor clam Sinonovacula constricta.
Insulin-like peptide (ILP) has emerged as a cell regulatory factor with multiple functions in vertebrates and invertebrates. In the present study, we identified and characterized two ILP genes, ILP1 and ILP2, in the razor clam Sinonovacula constricta. Both ILPs have a signal peptide and a mature domain consisting of six strictly conserved cysteines. The tertiary structure is divided into three main α-helices with a C-domain loop that separates helix 1 from helix 2. Both of ILPs were found to be regulated according to tissue type and developmental stage. After challenge with Vibrio anguillarum, Vibrio parahaemolyticus and Micrococcus lysodeikticus, the expression of two ILP genes was significantly up-regulated in the liver, hemocytes and mantle tissues, suggesting that the ILPs may play roles in the innate immunity in the razor clam Sinonovacula constricta. •Two insulin-like peptide (ILP) genes were characterized from the razor clam Sinonovacula constricta.•The ILP transcripts were widely expressed in adult tissues and the early developmental stages.•The expression of the two ILP genes was significantly up-regulated after infection.
Insulin-like peptide (ILP) has emerged as a cell regulatory factor with multiple functions in vertebrates and invertebrates. In the present study, we identified and characterized two ILP genes, ILP1 and ILP2, in the razor clam Sinonovacula constricta. Both ILPs have a signal peptide and a mature domain consisting of six strictly conserved cysteines. The tertiary structure is divided into three main alpha -helices with a C-domain loop that separates helix 1 from helix 2. Both of ILPs were found to be regulated according to tissue type and developmental stage. After challenge with Vibrio anguillarum, Vibrio parahaemolyticus and Micrococcus lysodeikticus, the expression of two ILP genes was significantly up-regulated in the liver, hemocytes and mantle tissues, suggesting that the ILPs may play roles in the innate immunity in the razor clam Sinonovacula constricta.
Author Zhao, Honggang
Niu, Donghong
Wang, Fei
Xie, Shumei
Wang, Ze
Li, Jiale
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Keywords Innate immunity
ILP
Insulin-like peptide
Sinonovacula constricta
Language English
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Snippet Insulin-like peptide (ILP) has emerged as a cell regulatory factor with multiple functions in vertebrates and invertebrates. In the present study, we...
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SubjectTerms Animals
Bacterial Infections - genetics
Bacterial Infections - immunology
Bacterial Infections - veterinary
Bivalvia - genetics
Bivalvia - immunology
Hemocytes - metabolism
ILP
Immunity, Innate
Innate immunity
Insulin-like peptide
Liver - metabolism
Micrococcus
Micrococcus lysodeikticus
Peptide Hormones - genetics
Peptide Hormones - immunology
Phylogeny
Sinonovacula constricta
Vibrio
Vibrio anguillarum
Vibrio parahaemolyticus
Title Identification, expression, and innate immune responses of two insulin-like peptide genes in the razor clam Sinonovacula constricta
URI https://dx.doi.org/10.1016/j.fsi.2016.03.012
https://www.ncbi.nlm.nih.gov/pubmed/26980611
https://search.proquest.com/docview/1777981792
https://search.proquest.com/docview/1785227458
Volume 51
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